Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome in Experimental Endotoxemia

• Published in: The American journal of pathology Vol. 191; no. 9; pp. 1526 - 1536
• Main Authors: Okamoto, Haruka, Muraki, Isamu, Okada, Hideshi, Tomita, Hiroyuki, Suzuki, Kodai, Takada, Chihiro, Wakayama, Yugo, Kuroda, Ayumi, Fukuda, Hirotsugu, Kawasaki, Yuki, Nishio, Ayane, Matsuo, Maho, Tamaoki, Yuto, Inagawa, Risa, Takashima, Shigeo, Taniguchi, Toshiaki, Suzuki, Akio, Suzuki, Keiko, Miyazaki, Nagisa, Kakino, Yoshinori, Yasuda, Ryu, Fukuta, Tetsuya, Kitagawa, Yuichiro, Miyake, Takahito, Doi, Tomoaki, Yoshida, Takahiro, Yoshida, Shozo, Ogura, Shinji
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2021; American Society for Investigative Pathology. Published by Elsevier Inc
• Subjects: Regular

Sepsis-induced endothelial acute respiratory distress syndrome is related to microvascular endothelial dysfunction caused by endothelial glycocalyx disruption. Recently, recombinant antithrombin (rAT) was reported to protect the endothelial glycocalyx from septic vasculitis; however, the underlying...