Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats

• Published in: Animal cells and systems Vol. 25; no. 6; pp. 396 - 404
• Main Authors: Jang, Mi Gyeong, Oh, Jung Min, Ko, Hee Chul, Kim, Jae-Won, Baek, Songyee, Jin, Yeong Jun, Hur, Sung-Pyo, Kim, Se-Jae
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.11.2021; Taylor & Francis Ltd; Taylor & Francis Group; 한국통합생물학회
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; AMP-activated protein kinase; Body weight; Carbohydrates; Clerodendrum trichotomum; Cytokines; Diet; Drinking water; Dyslipidemia; fatty acid metabolism; Fatty acids; Fatty liver; Fructose; high fructose diet; human health; hyperlipidemia; Insulin; Insulin resistance; Kinases; leaf extracts; liver; Metabolic disorders; Metabolic syndrome; Metabolism; Peroxisome proliferator-activated receptors; Plant extracts; Proteins; Receptors; Signal transduction; Signaling; Steatosis; Sterol regulatory element-binding protein; sterols; therapeutics; 생물학; metabolic disorders; high fructose diet; dyslipidemia; insulin resistance; Clerodendrum trichotomum
• ISSN: 1976-8354; 2151-2485; 2151-2485
• DOI: 10.1080/19768354.2021.2004221

Clerodendrum trichotomum has been reported to possess beneficial properties for human health, but its effects on metabolic syndrome have not been reported. In this study, we investigated the effect of C. trichotomum leaf extract (CT) on the metabolic derangements induced by a high-fructose (HF) diet. Sprague-Dawley rats were fed with a 46% carbohydrate diet (HC group), 60% high-fructose diet (HF group), or HF diet supplemented with CT (500 mg/kg of body weight/day, CT group) via drinking water for 16 weeks. Results showed that CT alleviated HF diet-induced insulin resistance, dyslipidemia, and hepatic steatosis In liver tissues, CT affected the signaling pathways of AMP-activated protein kinase, peroxisome proliferator-activated receptor α (PPARα), and sterol regulatory element binding protein 1. CT enriched the genes that were mainly involved in cytokine-cytokine receptor interaction, PPAR, PI3K-Akt signaling pathways, and fatty acid metabolism pathway. These results suggest that CT is a promising therapeutic against metabolic disorders.