Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis

• Published in: Stem cell research & therapy Vol. 7; no. 1; p. 43
• Main Authors: Bravo, Beatriz, Gallego, Marta I., Flores, Ana I., Bornstein, Rafael, Puente-Bedia, Alba, Hernández, Javier, de la Torre, Paz, García-Zaragoza, Elena, Perez-Tavarez, Raquel, Grande, Jesús, Ballester, Alicia, Ballester, Sara
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.03.2016; BioMed Central
• Subjects: Animals; Autoimmune diseases; Cell Differentiation; Cell Movement; Cells, Cultured; Decidua - cytology; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - therapy; Female; Health aspects; Humans; Immune response; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells - physiology; Mice, Inbred C57BL; Multiple Sclerosis - immunology; Multiple Sclerosis - therapy; Myeloid Cells - immunology; Stem cells; T cells; Testing; Th17 Cells - immunology; EAE; Placental mesenchymal stem cells; Immunomodulation; Th17

Multiple sclerosis is a widespread inflammatory demyelinating disease. Several immunomodulatory therapies are available, including interferon-β, glatiramer acetate, natalizumab, fingolimod, and mitoxantrone. Although useful to delay disease progression, they do not provide a definitive cure and are...