Effect of Quercetin on Dexamethasone-Induced C2C12 Skeletal Muscle Cell Injury

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 14; p. 3267
• Main Authors: Chen, Chun, Yang, Jai-Sing, Lu, Chi-Cheng, Chiu, Yu-Jen, Chen, Hung-Che, Chung, Mei-Ing, Wu, Yu-Tse, Chen, Fu-An
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.07.2020; MDPI
• Subjects: antioxidant; Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Atrophy; C2C12 skeletal muscle cells; Cell growth; Cell Survival - drug effects; Cytochrome; Deoxyribonucleic acid; dexamethasone; Dexamethasone - toxicity; DNA; DNA damage; Flavonoids - chemistry; Flavonoids - pharmacology; Gene expression; Glucocorticoids - chemistry; Glucocorticoids - pharmacology; Humans; Metabolism; Mitochondria; mitochondrial membrane potential (ΔΨm); Morphology; Muscle Fibers, Skeletal - drug effects; Muscle, Skeletal - drug effects; Muscle, Skeletal - injuries; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Muscular Atrophy - chemically induced; Muscular Atrophy - drug therapy; Muscular Atrophy - pathology; Musculoskeletal system; Phosphorylation; Protein expression; Proteins; quercetin; Quercetin - pharmacology; Sarcopenia; Signal transduction; Steroids; dexamethasone; apoptosis; quercetin; antioxidant; mitochondrial membrane potential (ΔΨm); C2C12 skeletal muscle cells

Glucocorticoids are widely used anti-inflammatory drugs in clinical settings. However, they can induce skeletal muscle atrophy by reducing fiber cross-sectional area and myofibrillar protein content. Studies have proven that antioxidants can improve glucocorticoid-induced skeletal muscle atrophy. Qu...