Upregulation of the proto-oncogene Bmi-1 predicts a poor prognosis in pediatric acute lymphoblastic leukemia

• Published in: BMC cancer Vol. 17; no. 1; p. 76
• Main Authors: Peng, Hong-Xia, Liu, Xiao-Dan, Luo, Zi-Yan, Zhang, Xiao-Hong, Luo, Xue-Qun, Chen, Xiao, Jiang, Hua, Xu, Ling
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.01.2017; BioMed Central
• Subjects: Acute lymphocytic leukemia; Analysis; Biomarkers, Tumor - genetics; Bone marrow; Cancer; Cell cycle; Child; Child health; Child, Preschool; Children & youth; Disease-Free Survival; Female; Gene expression; Gene Expression Regulation, Leukemic; Genetic aspects; Health aspects; Humans; Infant; Leukemia; Lymphoma; Male; Medical prognosis; Pathogenesis; Pediatrics; Polycomb Repressive Complex 1 - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; Prognosis; Remission (Medicine); Risk factors; Transcription Factors - genetics; Pediatric acute lymphoblastic leukemia; Sall4; Prognosis; Bmi-1

Bmi-1, the B cell-specific moloney murine leukemia virus insertion site 1, is a member of the Polycomb-group (PcG) family and acts as an oncogene in various tumors; however, its expression related to the prognosis of pediatric patients with acute lymphoblastic leukemia (ALL) has not been well studie...