Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

• Published in: PLoS pathogens Vol. 20; no. 10; p. e1012650
• Main Authors: Ruiz, Felicitas, Foreman, William B., Lilly, Michelle, Baharani, Viren A., Depierreux, Delphine M., Chohan, Vrasha, Taylor, Ashley L., Guenthoer, Jamie, Ralph, Duncan, Matsen IV, Frederick A., Chu, Helen Y., Bieniasz, Paul D., Côté, Marceline, Starr, Tyler N., Overbaugh, Julie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.10.2024; Public Library of Science (PLoS)
• Subjects: Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antigen-antibody reactions; Antigenic determinants; B cells; Betacoronavirus - immunology; Biology and life sciences; Care and treatment; Causes of; Coronavirus infections; Coronaviruses; COVID-19 - immunology; COVID-19 - virology; Cross Reactions - immunology; Development and progression; Epitopes - immunology; Health aspects; Humans; Immune response; Immunological research; Medicine and health sciences; Mice; Physiological aspects; Research and Analysis Methods; SARS-CoV-2 - immunology; Severe acute respiratory syndrome-related coronavirus - immunology; Spike Glycoprotein, Coronavirus - immunology; Viral antibodies; United States; China

The recurring spillover of pathogenic coronaviruses and demonstrated capacity of sarbecoviruses, such SARS-CoV-2, to rapidly evolve in humans underscores the need to better understand immune responses to this virus family. For this purpose, we characterized the functional breadth and potency of anti...