Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis

• Published in: Nutrition & metabolism Vol. 17; no. 1; p. 12
• Main Authors: Liu, Shih-Ping, Shibu, Marthandam Asokan, Tsai, Fuu-Jen, Hsu, Yuan-Man, Tsai, Chang-Hai, Chung, Jing-Gung, Yang, Jai-Sing, Tang, Chih-Hsin, Wang, Shulin, Li, Qiaowen, Huang, Chih-Yang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 31.01.2020; BMC
• Subjects: Apoptosis; BNIP3 protein; Cardiomyocytes; Cardiovascular disease; Caspase; Cell viability; Cytotoxicity; Diabetes; Diabetes mellitus; Flavors; Food flavoring; Gene expression; Glucose; HIF-1; Hyperglycemia; Hypoxia; hypoxia-inducible factor 1; Membranes; Metabolism; nutrition; patients; protein synthesis; Proteins; pyrazines; United States > US; Caspase; HIF-1; Hypoxia; Diabetes mellitus; Food flavoring

Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our previous research show that Tetramethylpyrazine (TMP), a food flavoring agent, represses the hypoxia induced BNIP3 expression attenuate myoca...