Detection of Concordance between Transcriptional Levels of GPCRs and Receptor-Activity-Modifying Proteins

• Published in: iScience Vol. 11; pp. 366 - 374
• Main Authors: Barbash, Shahar, Persson, Torbjörn, Lorenzen, Emily, Kazmi, Manija A., Huber, Thomas, Sakmar, Thomas P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.01.2019; Elsevier
• Subjects: Biological Sciences; Cell Biology; Molecular Biology; Molecular Biology; Biological Sciences; Cell Biology

A recent phylogenetic analysis showed global co-evolution of G protein-coupled receptors (GPCRs) and receptor-activity-modifying proteins (RAMPs) suggesting global interactions between these two protein families. Experimental validation of these findings is challenging because in humans whereas ther...