On the Evolutionary Stability of Mendelian Segregation
We present a model of a primary locus subject to viability selection and an unlinked locus that causes sex-specific modification of the segregation ratio at the primary locus. If there is a balanced polymorphism at the primary locus, a population undergoing Mendelian segregation can be invaded by mo...
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| Published in | Genetics (Austin) Vol. 170; no. 3; pp. 1345 - 1357 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Genetics Soc America
01.07.2005
Genetics Society of America |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0016-6731 1943-2631 1943-2631 |
| DOI | 10.1534/genetics.104.036889 |
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| Abstract | We present a model of a primary locus subject to viability selection and an unlinked locus that causes sex-specific modification of the segregation ratio at the primary locus. If there is a balanced polymorphism at the primary locus, a population undergoing Mendelian segregation can be invaded by modifier alleles that cause sex-specific biases in the segregation ratio. Even though this effect is particularly strong if reciprocal heterozygotes at the primary locus have distinct viabilities, as might occur with genomic imprinting, it also applies if reciprocal heterozygotes have equal viabilities. The expected outcome of the evolution of sex-specific segregation distorters is all-and-none segregation schemes in which one allele at the primary locus undergoes complete drive in spermatogenesis and the other allele undergoes complete drive in oogenesis. All-and-none segregation results in a population in which all individuals are maximally fit heterozygotes. Unlinked modifiers that alter the segregation ratio are unable to invade such a population. These results raise questions about the reasons for the ubiquity of Mendelian segregation. |
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| AbstractList | We present a model of a primary locus subject to viability selection and an unlinked locus that causes sex-specific modification of the segregation ratio at the primary locus. If there is a balanced polymorphism at the primary locus, a population undergoing Mendelian segregation can be invaded by modifier alleles that cause sex-specific biases in the segregation ratio. Even though this effect is particularly strong if reciprocal heterozygotes at the primary locus have distinct viabilities, as might occur with genomic imprinting, it also applies if reciprocal heterozygotes have equal viabilities. The expected outcome of the evolution of sex-specific segregation distorters is all-and-none segregation schemes in which one allele at the primary locus undergoes complete drive in spermatogenesis and the other allele undergoes complete drive in oogenesis. All-and-none segregation results in a population in which all individuals are maximally fit heterozygotes. Unlinked modifiers that alter the segregation ratio are unable to invade such a population. These results raise questions about the reasons for the ubiquity of Mendelian segregation. We present a model of a primary locus subject to viability selection and an unlinked locus that causes sex-specific modification of the segregation ratio at the primary locus. If there is a balanced polymorphism at the primary locus, a population undergoing Mendelian segregation can be invaded by modifier alleles that cause sex-specific biases in the segregation ratio. Even though this effect is particularly strong if reciprocal heterozygotes at the primary locus have distinct viabilities, as might occur with genomic imprinting, it also applies if reciprocal heterozygotes have equal viabilities. The expected outcome of the evolution of sex-specific segregation distorters is all-and-none segregation schemes in which one allele at the primary locus undergoes complete drive in spermatogenesis and the other allele undergoes complete drive in oogenesis. All-and-none segregation results in a population in which all individuals are maximally fit heterozygotes. Unlinked modifiers that alter the segregation ratio are unable to invade such a population. These results raise questions about the reasons for the ubiquity of Mendelian segregation. [PUBLICATION ABSTRACT] We present a model of a primary locus subject to viability selection and an unlinked locus that causes sex-specific modification of the segregation ratio at the primary locus. If there is a balanced polymorphism at the primary locus, a population undergoing Mendelian segregation can be invaded by modifier alleles that cause sex-specific biases in the segregation ratio. Even though this effect is particularly strong if reciprocal heterozygotes at the primary locus have distinct viabilities, as might occur with genomic imprinting, it also applies if reciprocal heterozygotes have equal viabilities. The expected outcome of the evolution of sex-specific segregation distorters is all-and-none segregation schemes in which one allele at the primary locus undergoes complete drive in spermatogenesis and the other allele undergoes complete drive in oogenesis. All-and-none segregation results in a population in which all individuals are maximally fit heterozygotes. Unlinked modifiers that alter the segregation ratio are unable to invade such a population. These results raise questions about the reasons for the ubiquity of Mendelian segregation.We present a model of a primary locus subject to viability selection and an unlinked locus that causes sex-specific modification of the segregation ratio at the primary locus. If there is a balanced polymorphism at the primary locus, a population undergoing Mendelian segregation can be invaded by modifier alleles that cause sex-specific biases in the segregation ratio. Even though this effect is particularly strong if reciprocal heterozygotes at the primary locus have distinct viabilities, as might occur with genomic imprinting, it also applies if reciprocal heterozygotes have equal viabilities. The expected outcome of the evolution of sex-specific segregation distorters is all-and-none segregation schemes in which one allele at the primary locus undergoes complete drive in spermatogenesis and the other allele undergoes complete drive in oogenesis. All-and-none segregation results in a population in which all individuals are maximally fit heterozygotes. Unlinked modifiers that alter the segregation ratio are unable to invade such a population. These results raise questions about the reasons for the ubiquity of Mendelian segregation. |
| Author | Ubeda, Francisco Haig, David |
| AuthorAffiliation | Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138 |
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| Author_xml | – sequence: 1 fullname: Ubeda, Francisco – sequence: 2 fullname: Haig, David |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15911587$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/hdy.1987.68 10.1016/0040-5809(76)90010-1 10.1534/genetics.103.021303 10.1146/annurev.ge.25.120191.002455 10.1093/genetics/155.1.283 10.1016/0040-5809(75)90012-X 10.1016/S0022-5193(05)80155-9 10.1093/genetics/42.3.326 10.1017/S0016672300025325 10.2135/cropsci1975.0011183X001500030002x 10.1098/rstb.1991.0057 10.1007/BF02409747 10.1007/s003350040003 10.1093/genetics/125.1.183 10.1086/285173 10.1046/j.1420-9101.1995.8030265.x 10.1016/0040-5809(73)90020-8 10.1146/annurev.ge.19.120185.001143 10.1086/284350 10.1093/genetics/27.4.395 10.1086/284251 10.1093/genetics/48.9.1185 10.1016/0168-9525(85)90074-5 10.1093/genetics/118.3.389 10.1007/BF00292777 10.1139/g63-010 10.1093/genetics/53.1.85 10.1038/hdy.1979.71 10.1093/genetics/130.4.899 |
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| References | (2022010800212510100_BIB8) 1985; 125 2022010800212510100_BIB4 (2022010800212510100_BIB15) 1991; 333 (2022010800212510100_BIB26) 2001; 12 (2022010800212510100_BIB34) 1990; 125 (2022010800212510100_BIB38) 1962; 93 (2022010800212510100_BIB12) 1981; 47 (2022010800212510100_BIB13) 1995; 8 2022010800212510100_BIB11 (2022010800212510100_BIB27) 2000; 155 (2022010800212510100_BIB28) 1992; 130 (2022010800212510100_BIB33) 1985; 1 (2022010800212510100_BIB2) 1957; 42 2022010800212510100_BIB5 2022010800212510100_BIB19 (2022010800212510100_BIB29) 1973; 4 (2022010800212510100_BIB30) 2001; 2 (2022010800212510100_BIB35) 1985; 19 (2022010800212510100_BIB37) 1977; 59 (2022010800212510100_BIB1) 1990; 55 (2022010800212510100_BIB23) 1975; 15 (2022010800212510100_BIB10) 1991; 137 (2022010800212510100_BIB31) 1942; 27 (2022010800212510100_BIB22) 1991; 25 (2022010800212510100_BIB6) 1979; 240 (2022010800212510100_BIB14) 1991; 153 (2022010800212510100_BIB32) 1966; 53 (2022010800212510100_BIB3) 1979; 43 (2022010800212510100_BIB7) 1988; 118 (2022010800212510100_BIB18) 1987; 58 (2022010800212510100_BIB21) 1963; 5 (2022010800212510100_BIB9) 1996; 34 (2022010800212510100_BIB16) 1975; 7 (2022010800212510100_BIB20) 1976; 10 (2022010800212510100_BIB17) 1984; 124 2022010800212510100_BIB25 (2022010800212510100_BIB36) 2004; 167 (2022010800212510100_BIB24) 1963; 48 1806752 - J Theor Biol. 1991 Dec 21;153(4):531-58 1812815 - Annu Rev Genet. 1991;25:511-57 2341030 - Genetics. 1990 May;125(1):183-91 1582564 - Genetics. 1992 Apr;130(4):899-907 17247701 - Genetics. 1957 May;42(3):326-35 17248181 - Genetics. 1963 Sep;48(9):1185-94 17247049 - Genetics. 1942 Jul;27(4):395-407 8691082 - J Math Biol. 1996;34(5-6):485-510 3130288 - Genetics. 1988 Mar;118(3):389-91 2164490 - Genet Res. 1990 Apr;55(2):97-100 11331939 - Mamm Genome. 2001 May;12(5):331-9 11253064 - Nat Rev Genet. 2001 Jan;2(1):21-32 982324 - Theor Popul Biol. 1976 OCT;10(2):127-32 15342542 - Genetics. 2004 Aug;167(4):2083-95 4779109 - Theor Popul Biol. 1973 Dec;4(4):446-65 837801 - Chromosoma. 1977 Feb 3;59(3):193-206 1145501 - Theor Popul Biol. 1975 Apr;7(2):168-74 105406 - Sci Am. 1979 Feb;240(2):134-43, 146 10790402 - Genetics. 2000 May;155(1):283-9 5900610 - Genetics. 1966 Jan;53(1):85-96 3909941 - Annu Rev Genet. 1985;19:179-208 |
| References_xml | – volume: 58 start-page: 401 year: 1987 ident: 2022010800212510100_BIB18 publication-title: Heredity doi: 10.1038/hdy.1987.68 – volume: 10 start-page: 127 year: 1976 ident: 2022010800212510100_BIB20 publication-title: Theor. Popul. Biol. doi: 10.1016/0040-5809(76)90010-1 – volume: 167 start-page: 2083 year: 2004 ident: 2022010800212510100_BIB36 publication-title: Genetics doi: 10.1534/genetics.103.021303 – volume: 240 start-page: 134 year: 1979 ident: 2022010800212510100_BIB6 publication-title: Sci. Am. – volume: 25 start-page: 511 year: 1991 ident: 2022010800212510100_BIB22 publication-title: Annu. Rev. Genet. doi: 10.1146/annurev.ge.25.120191.002455 – volume: 155 start-page: 283 year: 2000 ident: 2022010800212510100_BIB27 publication-title: Genetics doi: 10.1093/genetics/155.1.283 – ident: 2022010800212510100_BIB19 – ident: 2022010800212510100_BIB11 – volume: 7 start-page: 168 year: 1975 ident: 2022010800212510100_BIB16 publication-title: Theor. Popul. Biol. doi: 10.1016/0040-5809(75)90012-X – volume: 47 start-page: 141 year: 1981 ident: 2022010800212510100_BIB12 publication-title: Symp. Zool. Soc. Lond. – volume: 153 start-page: 531 year: 1991 ident: 2022010800212510100_BIB14 publication-title: J. Theor. Biol. doi: 10.1016/S0022-5193(05)80155-9 – volume: 42 start-page: 326 year: 1957 ident: 2022010800212510100_BIB2 publication-title: Genetics doi: 10.1093/genetics/42.3.326 – volume: 55 start-page: 97 year: 1990 ident: 2022010800212510100_BIB1 publication-title: Genet. Res. doi: 10.1017/S0016672300025325 – volume: 93 start-page: 319 year: 1962 ident: 2022010800212510100_BIB38 publication-title: Z. Vererbungsl. – volume: 15 start-page: 287 year: 1975 ident: 2022010800212510100_BIB23 publication-title: Crop Sci. doi: 10.2135/cropsci1975.0011183X001500030002x – ident: 2022010800212510100_BIB4 – volume: 333 start-page: 1 year: 1991 ident: 2022010800212510100_BIB15 publication-title: Philos. Trans. R. Soc. Lond. B doi: 10.1098/rstb.1991.0057 – volume: 34 start-page: 485 year: 1996 ident: 2022010800212510100_BIB9 publication-title: J. Math. Biol. doi: 10.1007/BF02409747 – volume: 2 start-page: 21 year: 2001 ident: 2022010800212510100_BIB30 publication-title: Nat. Rev. – ident: 2022010800212510100_BIB25 – volume: 12 start-page: 331 year: 2001 ident: 2022010800212510100_BIB26 publication-title: Mamm. Genome doi: 10.1007/s003350040003 – volume: 125 start-page: 183 year: 1990 ident: 2022010800212510100_BIB34 publication-title: Genetics doi: 10.1093/genetics/125.1.183 – volume: 137 start-page: 403 year: 1991 ident: 2022010800212510100_BIB10 publication-title: Am. Nat. doi: 10.1086/285173 – volume: 8 start-page: 265 year: 1995 ident: 2022010800212510100_BIB13 publication-title: J. Evol. Biol. doi: 10.1046/j.1420-9101.1995.8030265.x – volume: 4 start-page: 446 year: 1973 ident: 2022010800212510100_BIB29 publication-title: Theor. Popul. Biol. doi: 10.1016/0040-5809(73)90020-8 – volume: 19 start-page: 179 year: 1985 ident: 2022010800212510100_BIB35 publication-title: Annu. Rev. Genet. doi: 10.1146/annurev.ge.19.120185.001143 – volume: 125 start-page: 412 year: 1985 ident: 2022010800212510100_BIB8 publication-title: Am. Nat. doi: 10.1086/284350 – volume: 27 start-page: 395 year: 1942 ident: 2022010800212510100_BIB31 publication-title: Genetics doi: 10.1093/genetics/27.4.395 – volume: 124 start-page: 48 year: 1984 ident: 2022010800212510100_BIB17 publication-title: Am. Nat. doi: 10.1086/284251 – volume: 48 start-page: 1185 year: 1963 ident: 2022010800212510100_BIB24 publication-title: Genetics doi: 10.1093/genetics/48.9.1185 – volume: 1 start-page: 181 year: 1985 ident: 2022010800212510100_BIB33 publication-title: Trends Genet. doi: 10.1016/0168-9525(85)90074-5 – volume: 118 start-page: 389 year: 1988 ident: 2022010800212510100_BIB7 publication-title: Genetics doi: 10.1093/genetics/118.3.389 – ident: 2022010800212510100_BIB5 – volume: 59 start-page: 193 year: 1977 ident: 2022010800212510100_BIB37 publication-title: Chromosoma doi: 10.1007/BF00292777 – volume: 5 start-page: 65 year: 1963 ident: 2022010800212510100_BIB21 publication-title: Can. J. Genet. Cytol. doi: 10.1139/g63-010 – volume: 53 start-page: 85 year: 1966 ident: 2022010800212510100_BIB32 publication-title: Genetics doi: 10.1093/genetics/53.1.85 – volume: 43 start-page: 159 year: 1979 ident: 2022010800212510100_BIB3 publication-title: Heredity doi: 10.1038/hdy.1979.71 – volume: 130 start-page: 899 year: 1992 ident: 2022010800212510100_BIB28 publication-title: Genetics doi: 10.1093/genetics/130.4.899 – reference: 1145501 - Theor Popul Biol. 1975 Apr;7(2):168-74 – reference: 8691082 - J Math Biol. 1996;34(5-6):485-510 – reference: 837801 - Chromosoma. 1977 Feb 3;59(3):193-206 – reference: 982324 - Theor Popul Biol. 1976 OCT;10(2):127-32 – reference: 2341030 - Genetics. 1990 May;125(1):183-91 – reference: 10790402 - Genetics. 2000 May;155(1):283-9 – reference: 1806752 - J Theor Biol. 1991 Dec 21;153(4):531-58 – reference: 3130288 - Genetics. 1988 Mar;118(3):389-91 – reference: 17248181 - Genetics. 1963 Sep;48(9):1185-94 – reference: 17247701 - Genetics. 1957 May;42(3):326-35 – reference: 105406 - Sci Am. 1979 Feb;240(2):134-43, 146 – reference: 11331939 - Mamm Genome. 2001 May;12(5):331-9 – reference: 5900610 - Genetics. 1966 Jan;53(1):85-96 – reference: 2164490 - Genet Res. 1990 Apr;55(2):97-100 – reference: 3909941 - Annu Rev Genet. 1985;19:179-208 – reference: 4779109 - Theor Popul Biol. 1973 Dec;4(4):446-65 – reference: 11253064 - Nat Rev Genet. 2001 Jan;2(1):21-32 – reference: 17247049 - Genetics. 1942 Jul;27(4):395-407 – reference: 1582564 - Genetics. 1992 Apr;130(4):899-907 – reference: 1812815 - Annu Rev Genet. 1991;25:511-57 – reference: 15342542 - Genetics. 2004 Aug;167(4):2083-95 |
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| SubjectTerms | Chromosome Segregation - genetics Evolution Evolution, Molecular Gene loci Genes Genetic Load Genetics, Population Investigations Meiosis - genetics Models, Genetic Mutation Population genetics Sex Factors |
| Title | On the Evolutionary Stability of Mendelian Segregation |
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