Roles of Substance P and NK1 Receptor in the Brainstem in the Development of Emesis
The emetic response is primarily a protective reflex occurring in a wide variety of vertebrates in response to the ingestion of toxic compounds. The role of the nuclei in the brainstem, including the area postrema, nucleus tractus solitarius, the dorsal motor nucleus of the vagus, and the central pa...
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| Published in | Journal of Pharmacological Sciences Vol. 91; no. 2; pp. 87 - 94 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
The Japanese Pharmacological Society
2003
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The emetic response is primarily a protective reflex occurring in a wide variety of vertebrates in response to the ingestion of toxic compounds. The role of the nuclei in the brainstem, including the area postrema, nucleus tractus solitarius, the dorsal motor nucleus of the vagus, and the central pattern generator for vomiting, as well as the involvement of the abdominal visceral innervation relevant to the emetic reflex, have all been discussed by many researchers. The introduction of serotonin 5-HT3-receptor antagonists into clinical practice allowed for a dramatic improvement in the management of vomiting. However, vomiting still remains a significant problem. The mechanism of the emetic response is even more complicated than was first thought. This review attempts to bring together some of the evidence suggesting the roles of substance P and its receptor, neurokinin NK1 receptor, in the brainstem nuclei in the development of emesis. Accordingly, NK1-receptor antagonists might represent novel drugs for the management of major types of emesis. |
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| AbstractList | The emetic response is primarily a protective reflex occurring in a wide variety of vertebrates in response to the ingestion of toxic compounds. The role of the nuclei in the brainstem, including the area postrema, nucleus tractus solitarius, the dorsal motor nucleus of the vagus, and the central pattern generator for vomiting, as well as the involvement of the abdominal visceral innervation relevant to the emetic reflex, have all been discussed by many researchers. The introduction of serotonin 5-HT3-receptor antagonists into clinical practice allowed for a dramatic improvement in the management of vomiting. However, vomiting still remains a significant problem. The mechanism of the emetic response is even more complicated than was first thought. This review attempts to bring together some of the evidence suggesting the roles of substance P and its receptor, neurokinin NK1 receptor, in the brainstem nuclei in the development of emesis. Accordingly, NK1-receptor antagonists might represent novel drugs for the management of major types of emesis. |
| Author | Takano, Yukio Kamiya, Hiro-o Saito, Ryo |
| Author_xml | – sequence: 1 fullname: Saito, Ryo organization: Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University – sequence: 2 fullname: Takano, Yukio organization: Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University – sequence: 3 fullname: Kamiya, Hiro-o organization: Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University |
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| Cites_doi | 10.1016/0028-3908(92)90034-M 10.1016/S0169-328X(96)00248-3 10.1016/0014-2999(91)90852-H 10.1139/y90-047 10.1016/0165-1838(81)90007-2 10.1111/j.2042-7158.1989.tb06402.x 10.1097/00006254-198707000-00003 10.1016/0006-8993(89)90901-3 10.1007/BF00185613 10.1016/S0304-3940(98)00682-X 10.1016/S0028-3908(99)00113-6 10.1016/0014-2999(89)90700-0 10.1016/0028-3908(87)90100-6 10.1111/j.1476-5381.1989.tb11948.x 10.1002/ar.1090270302 10.1254/jjp.86.359 10.1002/(SICI)1096-9861(19981214)402:2<181::AID-CNE4>3.0.CO;2-B 10.1016/0031-9384(77)90103-2 10.1016/0014-2999(94)00622-E 10.1111/j.1476-5381.1988.tb11542.x 10.1016/0014-2999(96)00061-1 10.1111/j.1476-5381.1987.tb16844.x 10.1093/jnci/89.11.817 10.1146/annurev.ne.14.030191.001011 10.1016/0028-3908(93)90189-A 10.1016/0304-3940(79)95336-9 10.1016/S0014-2999(97)01370-8 10.1016/S0006-8993(98)00630-1 10.1152/ajpgi.1998.275.5.G1193 10.1016/S0168-0102(09)80001-1 10.1093/jnci/81.1.42 10.1111/j.1476-5381.1995.tb15118.x 10.1038/sj.bjp.0700888 10.1023/A:1008256115221 10.1016/0002-9149(87)90976-3 10.1016/S0304-3940(00)01113-7 10.1016/S0304-3940(98)00753-8 10.1016/0197-0186(93)90118-O 10.1097/00000539-200104000-00027 10.1111/j.1365-2125.1989.tb05345.x 10.1111/j.1476-5381.1995.tb16324.x 10.1111/j.1476-5381.1986.tb10227.x 10.1139/y90-038 10.1016/0006-8993(91)91654-J 10.1007/BF00178966 10.1111/j.1365-2826.1994.tb00600.x 10.1016/0031-9384(76)90171-2 10.1016/0002-8703(78)90311-3 10.1007/BF00711065 10.1038/bjc.1988.277 10.1097/00000542-199006000-00005 10.1016/0014-2999(81)90540-9 10.1007/BF00735276 10.1139/y90-036 10.1016/0091-3057(89)90235-9 10.1016/0304-3940(88)90287-X 10.1097/00001813-199204000-00001 10.1056/NEJM199003223221205 10.1016/0028-3908(94)90018-3 10.1016/0006-8993(83)90805-3 10.1016/S0168-0102(98)00106-0 10.1093/oso/9780195051063.003.0014 10.1016/0361-9230(94)90048-5 10.1038/sj.bjp.0703428 10.1002/1096-9861(20010205)430:2<222::AID-CNE1027>3.0.CO;2-Y 10.1002/cne.903430107 10.1038/330746a0 10.1016/0014-2999(93)90673-6 10.1016/S0028-3908(96)00020-2 10.1016/0028-3908(94)90162-7 10.1016/S0028-3908(99)00010-6 10.1016/0028-3908(96)00008-1 10.1016/0361-9230(94)90047-7 10.1111/j.1476-5381.1996.tb15761.x 10.1016/0166-4328(84)90220-1 10.1016/0098-2997(84)90006-2 10.1016/0091-3057(93)90126-E 10.1016/S0304-3940(01)02269-8 10.1159/000227054 |
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| References | 56 Kilpatrick GJ, Jones BJ and Tyers MB: Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding. Nature 330, 746 – 748 (1987) 74 Fukuda H, Koga T, Furukawa N, Nakamura E, Shiroshita Y: The tachykinin NK1 receptor antagonist GR205171 abolishes the retching activity of neurons comprising the central pattern generator for vomiting in dogs. Neurosci Res 33, 25 – 32 (1999) 17 Strominger NL, Knox AP and Carpenter DO: The connectivity of the area postrema in the ferret. Brain Res Bull 33, 33 – 47 (1994) 40 Bhandari P and Andrews PL: Preliminary evidence for the involvement of the putative 5-HT4 receptor in zacopride- and copper sulfate-induced vomiting in the ferret. Eur J Pharmacol 204, 273 – 280 (1991) 39 Higgins GA, Kilpatrick GJ, Bunce KT, Jones BJ and Tyers MB: 5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret. Br J Pharmacol 97, 247 – 255 (1989) 6 Wang SC and Borison HL: A new concept of organization of the central emetic mechanism: recent studies on the sites of action of apomorphine, copper sulfate and cardiac glycosides. Gastroenterology 22, 1 – 12 (1952) 38 Barnes NM and Sharp T: A review of central 5-HT receptors and their function. Neuropharmacology 38, 1083 – 1152 (1999) 21 Barnes JM, Barnes NM, Costall B, Naylor IL, Naylor RJ and Rudd JA: Topographical distribution of 5-HT3 receptor recognition sites in the ferret brain stem. Naunyn Schmiedebergs Arch Pharmacol 342, 17 – 21 (1990) 50 Andrews PL and Hawthorn J: Evidence for an extra-abdominal site of action for the 5-HT3 receptor antagonist BRL24924 in the inhibition of radiation-evoked emesis in the ferret. Neuropharmacology 26, 1367 – 1370 (1987) 1 Ahmed SS, Gupta RC and Brancato RR: Significance of nausea and vomiting during acute myocardial infarction. Am Heart J 95, 671 – 672 (1978) 70 Gardner CJ, Twissell DJ, Dale TJ, Gale JD, Jordan CC, Kilpatrick GJ, Bountra C and Ward P: The broad-spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonist GR203040. Br J Pharmacol 116, 3158 – 3163 (1995) 83 Mitchell D, Krusemark ML and Hafner D: Pica: a species relevant behavioral assay of motion sickness in the rat. Physiol Behav 18, 125 – 130 (1977) 26 Furukawa N, Fukuda H, Hatano M, Koga T and Shiroshita Y: A neurokinin-1 receptor antagonist reduced hypersalivation and gastric contractility related to emesis in dogs. Am J Physiol 275, G1193 – G1201 (1998) 59 Vilar’o MT, Cort’es R, Gerald C, Branchek TA, Palacios JM and Mengod G. L:calization of 5-HT4 receptor mRNA in rat brain by in situ hybridization histochemistry. Mol Brain Res 43, 356 – 360 (1996) 61 Carpenter DO, Briggs DB and Strominger N: Peptide-induced emesis in dogs. Behav Brain Res 11, 277 – 281 (1984) 77 Reynolds DJ, Barber NA, Grahame-Smith DG and Lesli RA: Cisplatin-evoked induction of c-fos protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-HT3 receptor antagonist granisetron (BRL 43694). Brain Res 565, 231 – 236 (1991) 58 King GL and Landauer MR: Effects of zacopride and BMY25801 (batanopride) on radiation-induced emesis and locomotor behavior in the ferret. J Pharmacol Exp Ther 253, 1026 – 1033 (1990) 85 Saeki M, Sakai M, Saito R, Kubota H, Ariumi H, Nago S, Takano Y and Kamiya H: Effects of a novel NK-1 receptor antagonist, HSP-117, on cisplatin-induced pica as a new assessment of delayed emesis in rats. Jpn J Pharmacol 86, 359 – 362 (2001) 41 Endo T, Minami M, Monma Y, Yoshioka M, Saito H and Parvez HS: Vagotomy and ondansetron (5-HT3 antagonist) inhibited the increase of serotonin concentration induced by cytotoxic drugs in the area postrema of ferrets. Biogenic Amines 9, 163 – 175 (1992) 63 Watson JW, Gonsalves SF, Fossa AA, McLean S, Seeger T, Obach S and Andrews PL: The anti-emetic effects of CP-99,994 in the ferret and the dog: role of the NK1 receptor. Br J Pharmacol 115, 84 – 94 (1995) 94 Ireland SJ and Tyers MB: Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol 90, 229 – 238 (1987) 80 Kris MG, Radford JE, Pizzo BA, Inabinet R, Hesketh A and Hesketh PJ: Use of an NK1 receptor antagonist to prevent delayed emesis after cisplatin. J Natl Cancer Inst 89, 817 – 818 (1997) 11 Knox AP, Strominger NL, Battles AH and Carpenter DO: The central connections of the vagus nerve in the ferret. Brain Res Bull 33, 49 – 63 (1994) 9 Hyland NP, Abrahams TP, Fuchs K, Burmeister MA and Hornby PJ: Organization and neurochemistry of vagal preganglionic neurons innervating the lower esophageal sphincter in ferrets. J Comp Neurol 430, 222 – 234 (2001) 10 Lang IM: Digestive tract motor correlates of vomiting and nausea. Can J Physiol Pharmacol 68, 242 – 253 (1990) 20 Stefanini E and Clement-Cormier Y: Detection of dopamine receptors in the area postrema. Br J Pharmacol 74, 257 – 260 (1981) 44 King GL and Landauer MR: Effects of zacopride and BMY25801 (batanopride) on radiation-induced emesis and locomotor behavior in the ferret. J Pharmacol Exp Ther 253, 1026 – 1033 (1990) 18 Wislocki GB and Putnam TJ: Further observations on the anatomy and physiology of the area pastremae. Anat Rec 27, 151 – 156 (1924) 86 Nakanishi S: Mammalian tachykinin receptors. Ann Rev Neurosci 14, 123 – 136 (1991) 93 Kilpatrick GJ, Jones BJ and Tyers MB: The distribution of specific binding of the 5-HT3 receptor ligand [3H]GR65630 in rat brain using quantitative autoradiography. Neurosci Lett 94, 156 – 160 (1988) 4 Herlihy T, McIvor ME, Cummings CC, Siu CO, Alikahn M: Nausea and vomiting during acute myocardial infarction and its relation to infarct size and location. Am J Cardiol 60, 20 – 22 (1987) 25 Miller AD and Wilson VJ: ‘Vomiting center’ reanalyzed: an electrical stimulation study. Brain Res 270, 154 – 158 (1983) 89 Bountra C, Gale JD, Gardner CJ, Jordan CC, Kilpatrick GJ, Twissell DJ and Ward P: Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs. Oncology 5, Suppl 1, 102 – 109 (1996) 90 d’Allens H, Aubert B, Bons J and Pappo M: Ondansetron: a specific 5-HT3 serotonin receptor inhibitor, a new antiemetic in oncology. Bull Cancer 78, 1139 – 1146 (1991) 72 Bountra C, Bunce K, Dale T, Gardner C, Jordan C, Twissell D and Ward P: Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. Eur J Pharmacol 249, R3 – R4 (1993) 30 Migita K, Hori N, Manako J, Saito R, Takano Y and Kamiya H: Effects of arginine-vasopressin on neuronal interaction from the area postrema to the nucleus tractus solitarii in rat brain slices. Neurosci Lett 256, 45 – 48 (1998) 88 Yoshikawa T, Yoshida N and Hosoki K: Involvement of dopamine D3 receptors in the area postrema in R(+)-7-OH-DPAT-induced emesis in the ferret. Eur J Pharmacol 301, 143 – 149 (1996) 36 Tyers MB and Freeman AJ: Mechanism of the anti-emetic activity of 5-HT3 receptor antagonists. Oncology 49, 263 – 268 (1992) 14 Gwyn DG, Leslie RA and Hopkins DA: Gastric afferents to the nucleus of the solitary tract in the cat. Neurosci Lett 14, 13 – 17 (1979) 28 Walberg F and Ottersen OP: Neuroactive amino acids in the area postrema. An immunocytochemical investigation in rat with some observations in cat and monkey (Macaca fascicularis). Anat Embryol 185, 529 – 545 (1992) 81 Baude A, Lanoir J, Vernier P and Puizillout JJ: Substance P-immunoreactivity in the dorsal medial region of the medulla in the cat: effects of nodosectomy. J Chem Neuroanat 2, 67 – 81 (1989) 51 Kris MG, Tyson LB, Clark RA and Gralla RJ: Oral ondansetron for the control of delayed emesis after cisplatin. Report of a phase II study and a review of completed trials to manage delayed emesis. Cancer 70, Suppl, 1012 – 1016 (1992) 12 Freeman AJ, Cunningham KT and Tyers MB: Selectivity of 5-HT3 receptor antagonists and anti-emetic mechanisms of action. Anticancer Drugs 3, 79 – 85 (1992) 64 Krowicki ZK and Hornby PJ: Substance P in the dorsal motor nucleus of the vagus evokes gastric motor inhibition via neurokinin 1 receptor in rat. J Pharmacol Exp Ther 293, 214 – 221 (2000) 31 Price MT and Olney JW: Excitatory amino acid antagonists as anti-emetics. Society for Neuroscience 16, Abstract, 377 (1990) 67 Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM, Ladduwahetty T, Keown L, Swain C, Baker R, Cascieri M, Ber E, Metzger J, MacIntyre DE, Hill RG and Hargreaves RJ: Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology 35, 1121 – 1129 (1996) 54 Round A and Wallis DI: The depolarizing action of 5-hydroxytryptamine on rabbit vagal afferent and sympathetic neurones in vitro and its selective blockade by ICS 205-930. Br J Pharmacol 88, 485 – 494 (1986) 42 Kris MG, Gralla RJ, Clark RA and Tyson LB: Phase II trials of the serotonin antagonist GR38032F for the control of vomiting caused by cisplatin. J National Cancer Inst 81, 42 – 46 (1989) 69 Andrews PL, Okada F, Woods AJ, Hagiwara H, Kakaimoto S, Toyoda M and Matsuki N: The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew. Br J Pharmacol 130, 1247 – 1254 (2000) 27 Bednar I, Qian M, Qureshi GA, Källström L, Johnson AE, Carrer H and Sodersten P: Glutamate inhibits ingestive behaviour. J Neuroendocrinol 6, 403 – 408 (1994) 73 Fukuda H, Koga T, Furukawa N, Nakamura E, Shiroshita Y: The tachykinin NK1 receptor antagonist GR205171 prevents vagal stimulation-induced retching but not neuronal transmission from emetic vagal afferents to solitary nucleus neurons in dogs. Brain Res 802, 221 – 231 (1998) 66 Saito R, Suehiro Y, Ariumi H, Migita K, Hori N, Hashiguchi T, Sakai M, Saeki M, Takano Y and Kamiya H: Anti-emetic effects of a novel NK-1 receptor antagonist HSP-117 in ferrets. Neurosci Lett 254, 169 – 172 (1998) 23 Baude A and Shigemoto R: Cellular and subcellular distribution of substance P receptor immunoreactivity in the dorsal vagal comple 44 88 45 46 47 48 49 90 91 92 93 50 94 52 53 10 54 11 55 12 56 13 57 14 58 15 59 16 17 18 19 (51) 1992; 70 1 2 3 4 5 7 8 9 60 61 62 63 20 64 21 65 22 66 23 67 24 68 25 69 26 27 28 29 (41) 1992; 9 (6) 1952; 22 70 71 72 73 30 74 31 75 32 76 33 77 34 78 35 79 36 37 38 39 80 81 82 83 (89) 1996; 5 40 84 85 42 86 43 87 |
| References_xml | – ident: 91 doi: 10.1016/0028-3908(92)90034-M – ident: 64 – volume: 22 start-page: 1 issn: 0016-5085 year: 1952 ident: 6 publication-title: Gastroenterology – ident: 59 doi: 10.1016/S0169-328X(96)00248-3 – ident: 40 doi: 10.1016/0014-2999(91)90852-H – volume: 70 start-page: 1012 issn: 0008-543X year: 1992 ident: 51 publication-title: Cancer – ident: 47 doi: 10.1139/y90-047 – ident: 15 doi: 10.1016/0165-1838(81)90007-2 – ident: 48 doi: 10.1111/j.2042-7158.1989.tb06402.x – ident: 31 – ident: 5 doi: 10.1097/00006254-198707000-00003 – ident: 33 doi: 10.1016/0006-8993(89)90901-3 – ident: 28 doi: 10.1007/BF00185613 – ident: 66 doi: 10.1016/S0304-3940(98)00682-X – ident: 75 doi: 10.1016/S0028-3908(99)00113-6 – ident: 57 doi: 10.1016/0014-2999(89)90700-0 – ident: 50 doi: 10.1016/0028-3908(87)90100-6 – ident: 39 doi: 10.1111/j.1476-5381.1989.tb11948.x – ident: 60 – ident: 18 doi: 10.1002/ar.1090270302 – ident: 85 doi: 10.1254/jjp.86.359 – ident: 23 doi: 10.1002/(SICI)1096-9861(19981214)402:2<181::AID-CNE4>3.0.CO;2-B – ident: 83 doi: 10.1016/0031-9384(77)90103-2 – ident: 87 doi: 10.1016/0014-2999(94)00622-E – ident: 92 – ident: 53 doi: 10.1111/j.1476-5381.1988.tb11542.x – ident: 88 doi: 10.1016/0014-2999(96)00061-1 – ident: 55 doi: 10.1111/j.1476-5381.1987.tb16844.x – ident: 80 doi: 10.1093/jnci/89.11.817 – ident: 86 doi: 10.1146/annurev.ne.14.030191.001011 – ident: 68 doi: 10.1016/0028-3908(93)90189-A – volume: 5 start-page: 102 issn: 0030-2414 year: 1996 ident: 89 publication-title: Oncology – ident: 14 doi: 10.1016/0304-3940(79)95336-9 – ident: 65 doi: 10.1016/S0014-2999(97)01370-8 – ident: 73 doi: 10.1016/S0006-8993(98)00630-1 – ident: 13 – ident: 26 doi: 10.1152/ajpgi.1998.275.5.G1193 – ident: 8 doi: 10.1016/S0168-0102(09)80001-1 – ident: 42 doi: 10.1093/jnci/81.1.42 – ident: 70 doi: 10.1111/j.1476-5381.1995.tb15118.x – ident: 76 doi: 10.1038/sj.bjp.0700888 – ident: 52 doi: 10.1023/A:1008256115221 – ident: 4 doi: 10.1016/0002-9149(87)90976-3 – ident: 24 doi: 10.1016/S0304-3940(00)01113-7 – ident: 58 – ident: 30 doi: 10.1016/S0304-3940(98)00753-8 – ident: 34 doi: 10.1016/0197-0186(93)90118-O – ident: 35 doi: 10.1097/00000539-200104000-00027 – ident: 46 doi: 10.1111/j.1365-2125.1989.tb05345.x – ident: 63 doi: 10.1111/j.1476-5381.1995.tb16324.x – ident: 54 doi: 10.1111/j.1476-5381.1986.tb10227.x – ident: 10 doi: 10.1139/y90-038 – ident: 44 – ident: 77 doi: 10.1016/0006-8993(91)91654-J – ident: 21 doi: 10.1007/BF00178966 – ident: 27 doi: 10.1111/j.1365-2826.1994.tb00600.x – ident: 82 doi: 10.1016/0031-9384(76)90171-2 – ident: 1 doi: 10.1016/0002-8703(78)90311-3 – ident: 19 doi: 10.1007/BF00711065 – ident: 49 doi: 10.1038/bjc.1988.277 – ident: 2 doi: 10.1097/00000542-199006000-00005 – ident: 20 doi: 10.1016/0014-2999(81)90540-9 – ident: 29 doi: 10.1007/BF00735276 – ident: 7 doi: 10.1139/y90-036 – ident: 45 doi: 10.1016/0091-3057(89)90235-9 – ident: 37 – ident: 93 doi: 10.1016/0304-3940(88)90287-X – ident: 12 doi: 10.1097/00001813-199204000-00001 – ident: 43 doi: 10.1056/NEJM199003223221205 – ident: 71 doi: 10.1016/0028-3908(94)90018-3 – ident: 81 – ident: 25 doi: 10.1016/0006-8993(83)90805-3 – ident: 74 doi: 10.1016/S0168-0102(98)00106-0 – volume: 9 start-page: 163 issn: 0168-8561 year: 1992 ident: 41 publication-title: Biogenic Amines – ident: 16 doi: 10.1093/oso/9780195051063.003.0014 – ident: 90 – ident: 11 doi: 10.1016/0361-9230(94)90048-5 – ident: 69 doi: 10.1038/sj.bjp.0703428 – ident: 9 doi: 10.1002/1096-9861(20010205)430:2<222::AID-CNE1027>3.0.CO;2-Y – ident: 94 doi: 10.1111/j.1476-5381.1987.tb16844.x – ident: 62 doi: 10.1002/cne.903430107 – ident: 56 doi: 10.1038/330746a0 – ident: 72 doi: 10.1016/0014-2999(93)90673-6 – ident: 67 doi: 10.1016/S0028-3908(96)00020-2 – ident: 22 doi: 10.1016/0028-3908(94)90162-7 – ident: 38 doi: 10.1016/S0028-3908(99)00010-6 – ident: 32 doi: 10.1016/0028-3908(96)00008-1 – ident: 17 doi: 10.1016/0361-9230(94)90047-7 – ident: 79 doi: 10.1111/j.1476-5381.1996.tb15761.x – ident: 61 doi: 10.1016/0166-4328(84)90220-1 – ident: 3 doi: 10.1016/0098-2997(84)90006-2 – ident: 84 doi: 10.1016/0091-3057(93)90126-E – ident: 78 doi: 10.1016/S0304-3940(01)02269-8 – ident: 36 doi: 10.1159/000227054 |
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| Title | Roles of Substance P and NK1 Receptor in the Brainstem in the Development of Emesis |
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