Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

• Published in: Journal of lipid research Vol. 57; no. 12; pp. 2099 - 2114
• Main Authors: Ertunc, Meric Erikci, Hotamisligil, Gökhan S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2016; The American Society for Biochemistry and Molecular Biology; Elsevier
• Series: Thematic Review Series: Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death
• Subjects: Adipose Tissue - metabolism; Adipose Tissue - pathology; Animals; diabetes; Energy Metabolism; Humans; inflammation; Inflammation Mediators - metabolism; Insulin Resistance; Lipid Metabolism; lipids; Liver - immunology; Liver - metabolism; Metabolic Diseases - immunology; Metabolic Diseases - metabolism; Muscle, Skeletal - metabolism; obesity; signaling lipids; Stress, Physiological; Thematic Review Series; lipids; signaling lipids; inflammation; diabetes; insulin resistance; obesity

Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids, and triglycerides. These molecules represent a highly efficient energy resource and can act as structural elements of membranes or as signaling molecules that regulate metabolic homeostasis through many mechani...