A Cyclodextrin-Based Controlled Release System in the Simulation of In Vitro Small Intestine

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 5; p. 1212
• Main Authors: Zheng, Danni, Xia, Liuxi, Ji, Hangyan, Jin, Zhengyu, Bai, Yuxiang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.03.2020; MDPI
• Subjects: alpha-Glucosidases - chemistry; alpha-Glucosidases - metabolism; Benzaldehydes - chemistry; Benzaldehydes - pharmacokinetics; beta-Cyclodextrins - chemistry; Calorimetry, Differential Scanning; controlled release; Curcumin - chemistry; Curcumin - pharmacokinetics; cyclodextrin-based system; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacokinetics; Drug Delivery Systems; Drug Liberation; Drugs; Enzymes; Glucan 1,4-alpha-Glucosidase - chemistry; Glucan 1,4-alpha-Glucosidase - metabolism; Glucosyltransferases - chemistry; Glucosyltransferases - metabolism; Hydrocarbons; in vitro simulation; Intestine, Small - drug effects; Intestine, Small - metabolism; Kinetics; Simulation; Small intestine; Spectroscopy, Fourier Transform Infrared; Substrate Specificity; Thermogravimetry; Vibration; β-cgtase; controlled release; in vitro simulation; small intestine; β-CGTase; cyclodextrin-based system

A novel cyclodextrin (CD)-based controlled release system was developed in the small intestine to control the rate of drug release, on the premise of enteric-coated tablets. The system was designed based on the enzymes exogenous β-cyclodextrin glycosyltransferase (β-CGTase) and endogenous maltase-gl...