Gut Microbiome Composition Linked to Inflammatory Factors and Cognitive Functions in First-Episode, Drug-Naive Major Depressive Disorder Patients

• Published in: Frontiers in neuroscience Vol. 15; p. 800764
• Main Authors: Liu, Penghong, Gao, Mingxue, Liu, Zhifen, Zhang, Yanyan, Tu, Hongwei, Lei, Lei, Wu, Peiyi, Zhang, Aixia, Yang, Chunxia, Li, Gaizhi, Sun, Ning, Zhang, Kerang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 28.01.2022; Frontiers Media S.A
• Subjects: Alistipes; Alzheimer's disease; Bacteroidaceae; Bacteroides; Bioinformatics; Brain research; Cognitive ability; cognitive function; Color; Cytokines; Dementia; diversity; Enzyme-linked immunosorbent assay; Fecal microflora; Feces; gut microbiome; IL-1β; Inflammation; inflammatory factors; Interleukin 10; Interleukin 6; Intestinal microflora; major depressive disorder; Memory; Mental depression; Mental disorders; Microbiomes; Microbiota; Nervous system; Neuroscience; Patients; Peripheral blood; rRNA; Tumor necrosis factor-α; cognitive function; diversity; gut microbiome; major depressive disorder; inflammatory factors

The microbiota-gut-brain axis, especially the inflammatory pathway, may play a critical role in the pathogenesis of cognitive impairment in major depressive disorder (MDD). However, studies on the microbiota-inflammatory-cognitive function axis in MDD are lacking. The aim of the present study was to...