Promoter and 3′-Untranslated-Region Haplotypes in the Vitamin D Receptor Gene Predispose to Osteoporotic Fracture: The Rotterdam Study

• Published in: American journal of human genetics Vol. 77; no. 5; pp. 807 - 823
• Main Authors: Fang, Yue, van Meurs, Joyce B.J., d'Alesio, Arnold, Jhamai, Mila, Zhao, Hongyan, Rivadeneira, Fernando, Hofman, Albert, van Leeuwen, Johannes P.T., Jehan, Frédéric, Pols, Huibert A.P., Uitterlinden, André G.
• Format: Journal Article
• Language: English
• Published: Chicago, IL Elsevier Inc 01.11.2005; University of Chicago Press; Cell Press; American Society of Human Genetics
• Subjects: 3' Untranslated Regions - genetics; Alleles; Biological and medical sciences; Diseases of the osteoarticular system; Fractures; Fractures, Bone - genetics; General aspects. Genetic counseling; Genetic Predisposition to Disease; Genotype; Haplotypes; Hormones; Humans; Injuries of the limb. Injuries of the spine; Medical genetics; Medical sciences; Molecular Sequence Data; Mutation; Osteoporosis; Osteoporosis - genetics; Osteoporosis. Osteomalacia. Paget disease; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptors, Calcitriol - genetics; Risk Factors; RNA, Messenger; Traumas. Diseases due to physical agents; Vitamin D; Human; Osteoporosis; Gene; Vitamin D; Transcription promoter; Diseases of the osteoarticular system; Genetics; Fracture; Trauma; Haplotype; Biological receptor
• ISSN: 0002-9297; 1537-6605
• DOI: 10.1086/497438

Polymorphisms of the vitamin D receptor gene (VDR) have been shown to be associated with several complex diseases, including osteoporosis, but the mechanisms are unknown and study results have been inconsistent. We therefore determined sequence variation across the major relevant parts of VDR, inclu...