The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes

• Published in: Journal of lipid research Vol. 60; no. 2; pp. 242 - 268
• Main Authors: Grabon, Aby, Bankaitis, Vytas A., McDermott, Mark I.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2019; The American Society for Biochemistry and Molecular Biology; Elsevier
• Series: Thematic Review Series: The Role of Phosphoinositides in Signaling and Disease
• Subjects: Animals; cell signaling; diseases; Eukaryota - cytology; Eukaryota - metabolism; Humans; lipid and membrane trafficking; lipid signaling; lipids • membranes; Phosphatidylinositols - metabolism; Phospholipid Transfer Proteins - chemistry; Phospholipid Transfer Proteins - metabolism; Signal Transduction; Thematic Review Series: The Role of Phosphoinositides in Signaling and Disease; lipid and membrane trafficking; diseases; lipid signaling; cell signaling; lipids • membranes

Phosphoinositides are key regulators of a large number of diverse cellular processes that include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and transcription. How a small number of chemically distinct phosphoinositide signals are functionally amplified to exert sp...