Synaptoproteomics of learned helpless rats involve energy metabolism and cellular remodeling pathways in depressive-like behavior and antidepressant response

• Published in: Neuropharmacology Vol. 60; no. 7; pp. 1243 - 1253
• Main Authors: Mallei, Alessandra, Giambelli, Roberto, Gass, Peter, Racagni, Giorgio, Mathé, Aleksander A., Vollmayr, Barbara, Popoli, Maurizio
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2011
• Subjects: Animals; Antidepressant; Antidepressive Agents, Tricyclic - pharmacology; Antidepressive Agents, Tricyclic - therapeutic use; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Computer Simulation; Depression - drug therapy; Depressive Disorder - drug therapy; Depressive Disorder - metabolism; Depressive Disorder - pathology; Disease Models, Animal; Down-Regulation; Energy Metabolism; Helplessness, Learned; Hippocampus - metabolism; Hippocampus - pathology; Learned helplessness; Male; Medicin och hälsovetenskap; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiology; Proteins - metabolism; Proteome - metabolism; Proteomics; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; Signal Transduction - physiology; Software; Synapses - metabolism; Synapses - physiology; Synaptosome; Treatment Outcome; Up-Regulation; Antidepressant; BCA; IPG; DRP-2; SDS; NT; 2-DE; IEF; NLH; SLC2A4; CHAPS; Tris; Synaptosome; Learned helplessness; p38; Proteomics; P/FC; HPC; IPA; LH; ERK; MAPKs

Although depression is a severe and life-threatening psychiatric illness, its pathogenesis still is essentially unknown. Recent studies highlighted the influence of environmental stress factors on an individual’s genetic predisposition to develop mood disorders. In the present study, we employed a w...