The influence of rat mesenchymal stem cell CD44 surface markers on cell growth, fibronectin expression, and cardiomyogenic differentiation on silk fibroin – Hyaluronic acid cardiac patches

• Published in: Biomaterials Vol. 31; no. 5; pp. 854 - 862
• Main Authors: Yang, Ming-Chia, Chi, Nai-Hsin, Chou, Nai-Kuan, Huang, Yi-You, Chung, Tze-Wen, Chang, Yu-Lin, Liu, Hwa-Chang, Shieh, Ming-Jium, Wang, Shoei-Shen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2010
• Subjects: Absorption; Advanced Basic Science; Animals; Biocompatible Materials - chemistry; Biomimetic Materials - chemistry; Cardiomyogenic differentiation; CD44 of mesenchymal stem cells; Cell Culture Techniques - methods; Cell Differentiation - physiology; Cell Membrane - metabolism; Cell Proliferation; Cells, Cultured; Crystallization - methods; Dentistry; Extracellular Matrix - chemistry; Fibroins - chemistry; Fibronectin expression; Fibronectins - metabolism; Hyaluronan Receptors - metabolism; Hyaluronic Acid - chemistry; Materials Testing; Myocytes, Cardiac - cytology; Myocytes, Cardiac - physiology; Particle Size; Porosity; Rats; Rats, Wistar; Silk fibroin/hyaluronic acid patches; Surface Properties; Tissue Engineering - methods; Silk fibroin/hyaluronic acid patches; CD44 of mesenchymal stem cells; Fibronectin expression; Cardiomyogenic differentiation

Since MSCs contain an abundant of CD44 surface markers, it is of interesting to investigate whether CD44 on rat MSC (rMSCs) influenced cell growth, fibronectin expression and cardiomyogenic differentiation on new SF/HA cardiac patches. For this investigation, we examined the influences of rMSCs with...