Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 24; p. 5789
• Main Authors: Breijyeh, Zeinab, Karaman, Rafik
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.12.2020; MDPI
• Subjects: Alzheimer Disease - diagnosis; Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer Disease - therapy; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animals; Biomarkers; Brain; Dementia; Disease; Disease Management; Disease Susceptibility; disease-modifying therapy; Enzymes; Homocysteine; Humans; Magnetic resonance imaging; Memory; Morphology; neurodegeneration; Neurodegenerative Diseases - etiology; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - therapy; Oxidative stress; Patients; Proteins; Review; Risk Assessment; Risk Factors; Severity of Illness Index; tau protein; tau Proteins - metabolism; β-amyloid peptide; chaperons; risk factors; Alzheimer’s disease; disease-modifying therapy; neurodegeneration; β-amyloid peptide; heat shock proteins; tau protein

Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities. AD is considered a multifactorial disease: two main hypotheses were proposed...