Role of Cholinergic Signaling in Alzheimer’s Disease

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 6; p. 1816
• Main Authors: Chen, Zhi-Ru, Huang, Jia-Bao, Yang, Shu-Long, Hong, Fen-Fang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.03.2022; MDPI
• Subjects: Acetylcholine - metabolism; Alzheimer Disease - drug therapy; Alzheimer's disease; Brain; Cholinergic Agents - therapeutic use; cholinergic signaling; Cognition & reasoning; Cognitive ability; Dementia; drugs and treatment of Alzheimer’s disease; Enzymes; Growth factors; Homeostasis; Humans; Hypotheses; Lipids; Memory; Metabolism; Nervous system; Neurodegeneration; neurodegenerative disease; Neurodegenerative Diseases - drug therapy; Neurons; Pathogenesis; Phosphorylation; Physiology; Proteins; Review; Signal Transduction; drugs and treatment of Alzheimer’s disease; cholinergic signaling; neurodegenerative disease; Alzheimer’s disease

Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer’s disease (AD), a progressive and commonly diagnosed neurodegenerative disease, is characterized by memory and cognitive decline and behavioral diso...