Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S]

• Published in: Journal of lipid research Vol. 57; no. 12; pp. 2130 - 2137
• Main Authors: Takahashi, Shogo, Fukami, Tatsuki, Masuo, Yusuke, Brocker, Chad N., Xie, Cen, Krausz, Kristopher W., Wolf, C. Roland, Henderson, Colin J., Gonzalez, Frank J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2016; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Animals; chenodeoxycholic acid; Cholic Acids - biosynthesis; Cyp2c70; Cytochrome P-450 Enzyme System - physiology; cytochrome P450; enzyme kinetics; Gene Expression; Hep G2 Cells; Humans; Kinetics; liver; Liver - enzymology; Male; Mice, Inbred C57BL; Mice, Knockout; muricholic acid; Oxidation-Reduction; Species Specificity; ursodeoxycholic acid; ursodeoxycholic acid; liver; Cyp2c70; cytochrome P450; muricholic acid; chenodeoxycholic acid; enzyme kinetics

Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and conjugation with taurine, glycine, glucuronic acid, and sulfate. Mice and rats can hydroxylate chenodeoxycholic acid (CDC...