The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
Baculovirus inhibitor of apoptosis repeat-containing 1 (Birc1) proteins have homology to several germline-encoded receptors of the innate immune system. However, their function in immune surveillance is not clear. Here we describe a Birc1e-dependent signaling pathway that restricted replication of t...
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| Published in | Nature Immunology Vol. 7; no. 3; pp. 318 - 325 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.03.2006
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Baculovirus inhibitor of apoptosis repeat-containing 1 (Birc1) proteins have homology to several germline-encoded receptors of the innate immune system. However, their function in immune surveillance is not clear. Here we describe a Birc1e-dependent signaling pathway that restricted replication of the intracellular pathogen
Legionella pneumophila
in mouse macrophages. Translocation of bacterial products into host-cell cytosol was essential for Birc1e-mediated control of bacterial replication. Caspase-1 was required for Birc1e-dependent antibacterial responses
ex vivo
in macrophages and in a mouse model of Legionnaires' disease. The interleukin 1β converting enzyme–protease-activating factor was necessary for
L. pneumophila
growth restriction, but interleukin 1β was not required. These results establish Birc1e as a nucleotide-binding oligomerization–leucine-rich repeat protein involved in the detection and control of intracellular
L. pneumophila
. |
|---|---|
| AbstractList | Baculovirus inhibitor of apoptosis repeat-containing 1 (Birc1) proteins have homology to several germline-encoded receptors of the innate immune system. However, their function in immune surveillance is not clear. Here we describe a Birc1e-dependent signaling pathway that restricted replication of the intracellular pathogen Legionella pneumophila in mouse macrophages. Translocation of bacterial products into host-cell cytosol was essential for Birc1e-mediated control of bacterial replication. Caspase-1 was required for Birc1e-dependent antibacterial responses ex vivo in macrophages and in a mouse model of Legionnaires' disease. The interleukin 1beta converting enzyme- protease-activating factor was necessary for L. pneumophila growth restriction, but interleukin 1beta was not required. These results establish Birc1e as a nucleotide-binding oligomerization-leucine-rich repeat protein involved in the detection and control of intracellular L. pneumophila. Baculovirus inhibitor of apoptosis repeat-containing 1 (Birc1) proteins have homology to several germline-encoded receptors of the innate immune system. However, their function in immune surveillance is not clear. Here we describe a Birc1e-dependent signaling pathway that restricted replication of the intracellular pathogen Legionella pneumophila in mouse macrophages. Translocation of bacterial products into host-cell cytosol was essential for Birc1e-mediated control of bacterial replication. Caspase-1 was required for Birc1e-dependent antibacterial responses ex vivo in macrophages and in a mouse model of Legionnaires' disease. The interleukin 1b converting enzyme-protease-activating factor was necessary for L. pneumophila growth restriction, but interleukin 1b was not required. These results establish Birc1e as a nucleotide-binding oligomerization-leucine-rich repeat protein involved in the detection and control of intracellular L. pneumophila. Baculovirus inhibitor of apoptosis repeat-containing 1 (Birc1) proteins have homology to several germline-encoded receptors of the innate immune system. However, their function in immune surveillance is not clear. Here we describe a Birc1e-dependent signaling pathway that restricted replication of the intracellular pathogen Legionella pneumophila in mouse macrophages. Translocation of bacterial products into host-cell cytosol was essential for Birc1e-mediated control of bacterial replication. Caspase-1 was required for Birc1e-dependent antibacterial responses ex vivo in macrophages and in a mouse model of Legionnaires' disease. The interleukin 1β converting enzyme–protease-activating factor was necessary for L. pneumophila growth restriction, but interleukin 1β was not required. These results establish Birc1e as a nucleotide-binding oligomerization–leucine-rich repeat protein involved in the detection and control of intracellular L. pneumophila . |
| Audience | Academic |
| Author | Dietrich, William F Long, E Michelle Roy, Craig R Dixit, Vishva M Flavell, Richard A Zamboni, Dario S Mariathasan, Sanjeev Ogura, Yasunori Kobayashi, Koichi S Kohlsdorf, Tiana Vance, Russell E Kuida, Keisuke |
| Author_xml | – sequence: 1 givenname: Craig R surname: Roy fullname: Roy, Craig R organization: Section of Microbial Pathogenesis, Yale University School of Medicine – sequence: 2 givenname: Dario S surname: Zamboni fullname: Zamboni, Dario S organization: Section of Microbial Pathogenesis, Yale University School of Medicine – sequence: 3 givenname: Koichi S surname: Kobayashi fullname: Kobayashi, Koichi S organization: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine – sequence: 4 givenname: Tiana surname: Kohlsdorf fullname: Kohlsdorf, Tiana organization: Department of Ecology and Evolutionary Biology, Yale University – sequence: 5 givenname: Yasunori surname: Ogura fullname: Ogura, Yasunori organization: Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine – sequence: 6 givenname: E Michelle surname: Long fullname: Long, E Michelle organization: Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School – sequence: 7 givenname: Russell E surname: Vance fullname: Vance, Russell E organization: Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School – sequence: 8 givenname: Keisuke surname: Kuida fullname: Kuida, Keisuke organization: Vertex Pharmaceuticals – sequence: 9 givenname: Sanjeev surname: Mariathasan fullname: Mariathasan, Sanjeev organization: Molecular Oncology Department, Genentech – sequence: 10 givenname: Vishva M surname: Dixit fullname: Dixit, Vishva M organization: Molecular Oncology Department, Genentech – sequence: 11 givenname: Richard A surname: Flavell fullname: Flavell, Richard A organization: Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine – sequence: 12 givenname: William F surname: Dietrich fullname: Dietrich, William F organization: Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16444259$$D View this record in MEDLINE/PubMed |
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| Snippet | Baculovirus inhibitor of apoptosis repeat-containing 1 (Birc1) proteins have homology to several germline-encoded receptors of the innate immune system.... |
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| SubjectTerms | Animals Bacterial Translocation Baculovirus Biomedical and Life Sciences Biomedicine Caspase 1 - immunology Caspase 1 - metabolism Cells, Cultured Disease Models, Animal Humans Immune system Immunoblotting Immunology Infectious Diseases Legionella pneumophila Legionella pneumophila - physiology Legionnaire's disease Legionnaires' Disease - immunology Macrophages - immunology Macrophages - microbiology Mice Neuronal Apoptosis-Inhibitory Protein - immunology Neuronal Apoptosis-Inhibitory Protein - metabolism Pathogens Signal Transduction - immunology Transfection Translocation |
| Title | The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection |
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