Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects
Inflammation is a natural protective mechanism that occurs when the body’s tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent...
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Published in | Molecules (Basel, Switzerland) Vol. 27; no. 1; p. 233 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
30.12.2021
MDPI |
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Abstract | Inflammation is a natural protective mechanism that occurs when the body’s tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit pro-inflammatory mediators’ activity or gene expression, including cyclooxygenase (COX). Various phenolic compounds can also act on transcription factors, such as nuclear factor-κB (NF-κB) or nuclear factor-erythroid factor 2-related factor 2 (Nrf-2), to up-or downregulate elements within the antioxidant response pathways. Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common human ailments, including hypertension, metabolic problems, incendiary infections, and neurodegenerative diseases. The inhibition of the angiotensin-converting enzyme (ACE) by phenolic compounds has been used to treat hypertension. The inhibition of carbohydrate hydrolyzing enzyme represents a type 2 diabetes mellitus therapy, and cholinesterase inhibition has been applied to treat Alzheimer’s disease (AD). Phenolic compounds have also demonstrated anti-inflammatory properties to treat skin diseases, rheumatoid arthritis, and inflammatory bowel disease. Plant extracts and phenolic compounds exert protective effects against oxidative stress and inflammation caused by airborne particulate matter, in addition to a range of anti-inflammatory, anticancer, anti-aging, antibacterial, and antiviral activities. Dietary polyphenols have been used to prevent and treat allergy-related diseases. The chemical and biological contributions of phenolic compounds to cardiovascular disease have also been described. This review summarizes the recent progress delineating the multifunctional roles of phenolic compounds, including their anti-inflammatory properties and the molecular pathways through which they exert anti-inflammatory effects on metabolic disorders. This study also discusses current issues and potential prospects for the therapeutic application of phenolic compounds to various human diseases. |
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AbstractList | Inflammation is a natural protective mechanism that occurs when the body’s tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit pro-inflammatory mediators’ activity or gene expression, including cyclooxygenase (COX). Various phenolic compounds can also act on transcription factors, such as nuclear factor-κB (NF-κB) or nuclear factor-erythroid factor 2-related factor 2 (Nrf-2), to up-or downregulate elements within the antioxidant response pathways. Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common human ailments, including hypertension, metabolic problems, incendiary infections, and neurodegenerative diseases. The inhibition of the angiotensin-converting enzyme (ACE) by phenolic compounds has been used to treat hypertension. The inhibition of carbohydrate hydrolyzing enzyme represents a type 2 diabetes mellitus therapy, and cholinesterase inhibition has been applied to treat Alzheimer’s disease (AD). Phenolic compounds have also demonstrated anti-inflammatory properties to treat skin diseases, rheumatoid arthritis, and inflammatory bowel disease. Plant extracts and phenolic compounds exert protective effects against oxidative stress and inflammation caused by airborne particulate matter, in addition to a range of anti-inflammatory, anticancer, anti-aging, antibacterial, and antiviral activities. Dietary polyphenols have been used to prevent and treat allergy-related diseases. The chemical and biological contributions of phenolic compounds to cardiovascular disease have also been described. This review summarizes the recent progress delineating the multifunctional roles of phenolic compounds, including their anti-inflammatory properties and the molecular pathways through which they exert anti-inflammatory effects on metabolic disorders. This study also discusses current issues and potential prospects for the therapeutic application of phenolic compounds to various human diseases. Inflammation is a natural protective mechanism that occurs when the body's tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit pro-inflammatory mediators' activity or gene expression, including cyclooxygenase (COX). Various phenolic compounds can also act on transcription factors, such as nuclear factor-κB (NF-κB) or nuclear factor-erythroid factor 2-related factor 2 (Nrf-2), to up-or downregulate elements within the antioxidant response pathways. Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common human ailments, including hypertension, metabolic problems, incendiary infections, and neurodegenerative diseases. The inhibition of the angiotensin-converting enzyme (ACE) by phenolic compounds has been used to treat hypertension. The inhibition of carbohydrate hydrolyzing enzyme represents a type 2 diabetes mellitus therapy, and cholinesterase inhibition has been applied to treat Alzheimer's disease (AD). Phenolic compounds have also demonstrated anti-inflammatory properties to treat skin diseases, rheumatoid arthritis, and inflammatory bowel disease. Plant extracts and phenolic compounds exert protective effects against oxidative stress and inflammation caused by airborne particulate matter, in addition to a range of anti-inflammatory, anticancer, anti-aging, antibacterial, and antiviral activities. Dietary polyphenols have been used to prevent and treat allergy-related diseases. The chemical and biological contributions of phenolic compounds to cardiovascular disease have also been described. This review summarizes the recent progress delineating the multifunctional roles of phenolic compounds, including their anti-inflammatory properties and the molecular pathways through which they exert anti-inflammatory effects on metabolic disorders. This study also discusses current issues and potential prospects for the therapeutic application of phenolic compounds to various human diseases.Inflammation is a natural protective mechanism that occurs when the body's tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent diseases. Some phenolic compounds work in tandem with nonsteroidal anti-inflammatory drugs (NSAIDs) to inhibit pro-inflammatory mediators' activity or gene expression, including cyclooxygenase (COX). Various phenolic compounds can also act on transcription factors, such as nuclear factor-κB (NF-κB) or nuclear factor-erythroid factor 2-related factor 2 (Nrf-2), to up-or downregulate elements within the antioxidant response pathways. Phenolic compounds can inhibit enzymes associated with the development of human diseases and have been used to treat various common human ailments, including hypertension, metabolic problems, incendiary infections, and neurodegenerative diseases. The inhibition of the angiotensin-converting enzyme (ACE) by phenolic compounds has been used to treat hypertension. The inhibition of carbohydrate hydrolyzing enzyme represents a type 2 diabetes mellitus therapy, and cholinesterase inhibition has been applied to treat Alzheimer's disease (AD). Phenolic compounds have also demonstrated anti-inflammatory properties to treat skin diseases, rheumatoid arthritis, and inflammatory bowel disease. Plant extracts and phenolic compounds exert protective effects against oxidative stress and inflammation caused by airborne particulate matter, in addition to a range of anti-inflammatory, anticancer, anti-aging, antibacterial, and antiviral activities. Dietary polyphenols have been used to prevent and treat allergy-related diseases. The chemical and biological contributions of phenolic compounds to cardiovascular disease have also been described. This review summarizes the recent progress delineating the multifunctional roles of phenolic compounds, including their anti-inflammatory properties and the molecular pathways through which they exert anti-inflammatory effects on metabolic disorders. This study also discusses current issues and potential prospects for the therapeutic application of phenolic compounds to various human diseases. |
Author | Islam, Md. Rezaul Rahman, Md. Mominur Mithi, Faria Mannan Rahaman, Md. Saidur Emran, Talha Bin Almikhlafi, Mohannad A. Alruwaili, Abdullah S Alghamdi, Samia Qasem Alqahtani, Taha Ahmed, Muniruddin Rahman, Firoza Hossain, Md. Sohel Uddin, Md. Sahab Das, Rajib |
AuthorAffiliation | 9 Pharmakon Neuroscience Research Network, Dhaka 1207, Bangladesh 7 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh 5 Department of Clinical Laboratory, College of Applied Medical Science, Northern Border University, P.O. Box 1321, Arar 9280, Saudi Arabia; Dr.d-d@hotmail.com 1 Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh; mominur.ph@gmail.com (M.M.R.); mdsaidur569@gmail.com (M.S.R.); md.rezaulislam100ds@gmail.com (M.R.I.); 940sumaiya@gmail.com (F.R.); mithilafaria43@gmail.com (F.M.M.); sohelhossain1173@gmail.com (M.S.H.); drmuniruddin@gmail.com (M.A.) 3 Department of Pharmacology and Toxicology, Taibah University, Madinah 41477, Saudi Arabia; mmikhlafi@taibahu.edu.sa 2 Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia; ttaha@kku.edu.sa 8 Department of Pharmacy, Southeast University, Dhaka 1213, Bangladesh 4 Department of Biology, Faculty |
AuthorAffiliation_xml | – name: 6 Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh; rajibjony97@gmail.com – name: 2 Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia; ttaha@kku.edu.sa – name: 1 Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh; mominur.ph@gmail.com (M.M.R.); mdsaidur569@gmail.com (M.S.R.); md.rezaulislam100ds@gmail.com (M.R.I.); 940sumaiya@gmail.com (F.R.); mithilafaria43@gmail.com (F.M.M.); sohelhossain1173@gmail.com (M.S.H.); drmuniruddin@gmail.com (M.A.) – name: 3 Department of Pharmacology and Toxicology, Taibah University, Madinah 41477, Saudi Arabia; mmikhlafi@taibahu.edu.sa – name: 4 Department of Biology, Faculty of Science, Al-Baha University, Albaha 65527, Saudi Arabia; sqassim@bu.edu.sa – name: 9 Pharmakon Neuroscience Research Network, Dhaka 1207, Bangladesh – name: 7 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh – name: 5 Department of Clinical Laboratory, College of Applied Medical Science, Northern Border University, P.O. Box 1321, Arar 9280, Saudi Arabia; Dr.d-d@hotmail.com – name: 8 Department of Pharmacy, Southeast University, Dhaka 1213, Bangladesh |
Author_xml | – sequence: 1 givenname: Md. Mominur orcidid: 0000-0003-2357-283X surname: Rahman fullname: Rahman, Md. Mominur – sequence: 2 givenname: Md. Saidur orcidid: 0000-0002-6634-3255 surname: Rahaman fullname: Rahaman, Md. Saidur – sequence: 3 givenname: Md. Rezaul surname: Islam fullname: Islam, Md. Rezaul – sequence: 4 givenname: Firoza surname: Rahman fullname: Rahman, Firoza – sequence: 5 givenname: Faria Mannan orcidid: 0000-0001-7824-0117 surname: Mithi fullname: Mithi, Faria Mannan – sequence: 6 givenname: Taha orcidid: 0000-0003-4017-8754 surname: Alqahtani fullname: Alqahtani, Taha – sequence: 7 givenname: Mohannad A. orcidid: 0000-0002-4499-8605 surname: Almikhlafi fullname: Almikhlafi, Mohannad A. – sequence: 8 givenname: Samia Qasem orcidid: 0000-0001-9292-7900 surname: Alghamdi fullname: Alghamdi, Samia Qasem – sequence: 9 givenname: Abdullah S surname: Alruwaili fullname: Alruwaili, Abdullah S – sequence: 10 givenname: Md. Sohel surname: Hossain fullname: Hossain, Md. Sohel – sequence: 11 givenname: Muniruddin surname: Ahmed fullname: Ahmed, Muniruddin – sequence: 12 givenname: Rajib orcidid: 0000-0001-7852-4080 surname: Das fullname: Das, Rajib – sequence: 13 givenname: Talha Bin orcidid: 0000-0003-3188-2272 surname: Emran fullname: Emran, Talha Bin – sequence: 14 givenname: Md. Sahab orcidid: 0000-0002-0805-7840 surname: Uddin fullname: Uddin, Md. Sahab |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35011465$$D View this record in MEDLINE/PubMed |
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Keywords | phenolic compounds cardiovascular disease antioxidant inflammation diabetic mellitus hypertension |
Language | English |
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Title | Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects |
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