HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production

• Published in: Redox biology Vol. 15; no. C; pp. 97 - 108
• Main Authors: El-Amine, Rawan, Germini, Diego, Zakharova, Vlada V., Tsfasman, Tatyana, Sheval, Eugene V., Louzada, Ruy A.N., Dupuy, Corinne, Bilhou-Nabera, Chrystèle, Hamade, Aline, Najjar, Fadia, Oksenhendler, Eric, Lipinski, Marс, Chernyak, Boris V., Vassetzky, Yegor S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2018; Elsevier
• Subjects: B-cell lymphomas; B-Lymphocytes - pathology; B-Lymphocytes - virology; Cancer; DNA damage; DNA Damage - genetics; Glutathione - metabolism; HIV-1; HIV-1 - genetics; HIV-1 - pathogenicity; Humans; Life Sciences; Mitochondria; Mitochondria - genetics; Mitochondria - pathology; NF-kappa B - genetics; Oxidative stress; Oxidative Stress - genetics; Reactive Oxygen Species - metabolism; Research Paper; Signal Transduction; Tat; tat Gene Products, Human Immunodeficiency Virus - genetics; tat Gene Products, Human Immunodeficiency Virus - metabolism; HIV-1; Oxidative stress; Mitochondria; B-cell lymphomas; Tat; DNA damage

Human immunodeficiency virus (HIV) infection is associated with B-cell malignancies in patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV-infected individuals remains high even under the combined antiretroviral therapy (cART) that reconstitutes the immune functi...