Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring

• Published in: Metabolism, clinical and experimental Vol. 116; p. 154704
• Main Authors: Stevanović-Silva, Jelena, Beleza, Jorge, Coxito, Pedro, Pereira, Susana, Rocha, Hugo, Gaspar, Tiago Bordeira, Gärtner, Fátima, Correia, Rossana, Martins, Maria João, Guimarães, Tiago, Martins, Sandra, Oliveira, Paulo J., Ascensão, António, Magalhães, José
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2021
• Subjects: Animals; Cell Respiration - drug effects; Diabetes, Gestational - metabolism; Diabetes, Gestational - physiopathology; Diet, High-Fat - adverse effects; Dietary Carbohydrates - adverse effects; Female; Fetal programming; Gestational diabetes; Lipid Metabolism - drug effects; Liver - metabolism; Liver mitochondria; Male; Maternal Nutritional Physiological Phenomena; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Mothers; Physical activity; Physical Conditioning, Animal - physiology; Pregnancy; Prenatal Exposure Delayed Effects - metabolism; Prenatal Exposure Delayed Effects - physiopathology; Rats; Rats, Sprague-Dawley; Sucrose - administration & dosage; RCR; T2DM; NAFLD; C; G/M; Physical activity; HFD; ALT; OXPHOS; FCCP; AUC; GDM; HDL; LDL; S/R; UCP2; AST; HFHS; IR; Fetal programming; Liver mitochondria; Pregnancy; TG; ETC; FA; Gestational diabetes; OGTT

Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated...