Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 7; p. 1719
• Main Authors: Gupta, Deepak, Bhatia, Deepak, Dave, Vivek, Sutariya, Vijaykumar, Varghese Gupta, Sheeba
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.07.2018; MDPI
• Subjects: Biological properties; Chemical compounds; chemistry; degradation; Drug development; Organic chemistry; Pharmaceuticals; Pharmacodynamics; Pharmacokinetics; Pharmacology; physicochemical; Review; Reviews; routes of administration; salt; Salts; stability; water solubility; chemistry; salt; degradation; routes of administration; water solubility; physicochemical; stability

The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The approp...