Src Is a Potential Therapeutic Target in Endocrine-Resistant Breast Cancer Exhibiting Low Estrogen Receptor-Mediated Transactivation

• Published in: PloS one Vol. 11; no. 6; p. e0157397
• Main Authors: Guest, Stephanie K, Ribas, Ricardo, Pancholi, Sunil, Nikitorowicz-Buniak, Joanna, Simigdala, Nikiana, Dowsett, Mitch, Johnston, Stephen R, Martin, Lesley-Ann
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2016; Public Library of Science (PLoS)
• Subjects: AKT protein; Antineoplastic Agents, Hormonal - pharmacology; Aromatase; Biology and Life Sciences; Biotechnology; Breast cancer; Cancer; Cell culture; Cell cycle; Cell Line, Tumor; Cell migration; Cell Movement - drug effects; Cell proliferation; Cell Proliferation - drug effects; Clinical trials; Dasatinib - pharmacology; Deprivation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm - genetics; Endocrine therapy; Estradiol - analogs & derivatives; Estradiol - pharmacology; Estrogen receptors; Estrogens; Extracellular signal-regulated kinase; Female; Fulvestrant; Gene expression; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulins; Inhibition; Kinases; MCF-7 Cells; Medical research; Medicine and Health Sciences; Metastasis; Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 1 - genetics; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 3 - genetics; Mitogen-Activated Protein Kinase 3 - metabolism; Nuclei; Nuclei (cytology); Patients; Phenols; Phosphorylation; Phosphorylation - drug effects; Physical Sciences; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism; Research and Analysis Methods; Sarcoma; Signal Transduction; Src protein; src-Family Kinases - antagonists & inhibitors; src-Family Kinases - genetics; src-Family Kinases - metabolism; Tamoxifen; Tamoxifen - pharmacology; Therapeutic applications; Transcription; Transcriptional Activation; United States > US

Despite the effectiveness of endocrine therapies in estrogen receptor positive (ER+) breast cancer, approximately 40% of patients relapse. Previously, we identified the Focal-adhesion kinase canonical pathway as a major contributor of resistance to estrogen deprivation and cellular-sarcoma kinase (c...