Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

• Published in: Nature cell biology Vol. 11; no. 5; pp. 604 - 615
• Main Authors: Garinis, George A., Uittenboogaard, Lieneke M., Stachelscheid, Heike, Fousteri, Maria, van Ijcken, Wilfred, Breit, Timo M., van Steeg, Harry, Mullenders, Leon H. F., van der Horst, Gijsbertus T. J., Brüning, Jens C., Niessen, Carien M., Hoeijmakers, Jan H. J., Schumacher, Björn
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2009; Nature Publishing Group
• Subjects: Accumulation; Aging; Aging - physiology; Animal Structures - metabolism; Animals; Biology; Biomedical and Life Sciences; Cancer; Cancer Research; Causes of; Cell Biology; Deoxyribonucleic acid; Developmental Biology; DNA; DNA - radiation effects; DNA damage; DNA Damage - physiology; DNA Repair - physiology; Gene expression; Gene Expression Profiling; Genetic aspects; Genetics; Genomes; Growth - physiology; Growth - radiation effects; Growth factors; Health aspects; Humans; Insulin-like growth factors; Lesions; Life Sciences; Life span; Longevity; Longevity - physiology; Longevity - radiation effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Mutation; Neoplasms - etiology; Neoplasms - genetics; Oxidative stress; Oxidative Stress - physiology; Progeria - genetics; Progeria - metabolism; Rats; Receptor, IGF Type 1 - genetics; Receptor, IGF Type 1 - metabolism; Receptors, Somatotropin - genetics; Receptors, Somatotropin - metabolism; RNA polymerase; RNA Polymerase II - metabolism; Stem Cells; Stress, Physiological - physiology; Transcription, Genetic - genetics; Transcription, Genetic - radiation effects; Ultraviolet Rays; Netherlands; Germany

The 'somatic growth axis' involving IGF-1 and growth hormone is implicated in longevity. Persistent transcription-blocking DNA damage attenuates growth hormone and IGF-1 receptor expression and precipitates other ageing associated transcriptional changes, as well as inhibiting somatic grow...