Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression

• Published in: Journal of lipid research Vol. 59; no. 10; pp. 1977 - 1986
• Main Authors: Peng, Kang-Yu, Watt, Matthew J., Rensen, Sander, Greve, Jan Willem, Huynh, Kevin, Jayawardana, Kaushala S., Meikle, Peter J., Meex, Ruth C.R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2018; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Adult; Cohort Studies; Disease Progression; Female; Humans; Lipid Metabolism; lipidomics; Liver - metabolism; Liver - pathology; Male; Middle Aged; mitochondria; Mitochondria - pathology; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; obesity; Patient-Oriented and Epidemiological Research; liver metabolism; mitochondria; lipidomics; obesity

Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within hepatocytes that can cause severe liver damage and metabolic comorbidities. Studies suggest that mitochondrial dysfunction contributes to its development and progression and that the hepatic lipidome changes extens...