Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain

• Published in: Annals of hematology Vol. 89; no. 8; pp. 767 - 773
• Main Authors: Aranda, Núria, Viteri, Fernando E, Montserrat, Carme, Arija, Victoria
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.08.2010; Springer-Verlag; Springer Nature B.V; Springer Verlag
• Subjects: Adolescent; Adult; Aged; C282Y variant; Diet; Female; Ferritins - blood; Genetic Predisposition to Disease; Genotype; H63D variant; Hematology; Hemochromatosis - blood; Hemochromatosis - genetics; Hemochromatosis Protein; HFE gene; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - metabolism; Humans; Iron - blood; Iron overload; Iron Overload - blood; Iron Overload - genetics; Life Style; Male; Medicine; Medicine & Public Health; Mediterranean diet; Mediterranean Region; Membrane Proteins - genetics; Membrane Proteins - metabolism; Middle Aged; Mutation; Oncology; Original; Original Article; Polymorphism, Genetic; S65C variant; Spain; Transferrin; Young Adult; Iron overload; S65C variant; H63D variant; HFE gene; C282Y variant; Mediterranean diet

Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among ge...