Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis

• Published in: Frontiers in cellular neuroscience Vol. 15; p. 632354
• Main Authors: Chen, Junmin, Yang, Lan, Geng, Lianxia, He, Junna, Chen, Lei, Sun, Qian, Zhao, Jing, Wang, Xiaopeng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 06.04.2021; Frontiers Media S.A
• Subjects: ACSL4; Alzheimer's disease; Apoptosis; Brain injury; Carotid arteries; Cell death; Cerebral blood flow; cerebral ischemia; Cristae; Cyclooxygenase-2; Enzymes; Experiments; Ferroptosis; Gait; Glutathione peroxidase; GPx4; Iron; Ischemia; Laboratory animals; Lipid peroxidation; Malondialdehyde; Mitochondria; neurological recovery; Neuroscience; Oxidative stress; Peroxide; Reactive oxygen species; Rosiglitazone; Stroke; Superoxide; Transmission electron microscopy; Traumatic brain injury; Veins & arteries; China; ACSL4; ferroptosis; GPx4; cerebral ischemia; neurological recovery

Ischemic stroke is the main cause of disability worldwide, leading to a serious socioeconomic burden. Ferroptosis is a non-apoptotic form of programmed cell death and is related to various diseases. Acyl-CoA synthetase long-chain family member 4 (ACSL4) is considered a target of ferroptosis, but its...