Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets

• Published in: Frontiers in neural circuits Vol. 15; p. 638007
• Main Authors: Breton-Provencher, Vincent, Drummond, Gabrielle T., Sur, Mriganka
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 07.06.2021; Frontiers Media S.A
• Subjects: Alzheimer's disease; Arousal; Behavior; Brain; Brain stem; Cerebellum; Dopamine; Experiments; Forebrain; Hypothalamus; inhibition; learning; Locus Coeruleus; Neural Circuits; Neuromodulation; Neurons; Neuropeptides; noradrenaline (norepinephrine); Norepinephrine; Rabies; Spinal cord; neuromodulation; noradrenaline (norepinephrine); learned behavior; inhibition; learning; locus coeruleus; arousal

The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread brain regions, and projects throughout the forebrain, brainstem, cerebellum, and spinal cord. LC neurons release NE to control arou...