Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus

Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional poly...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 22; p. 6899
Main Authors Cicalău, Georgiana, Babes, Petru, Calniceanu, Horia, Popa, Adelina, Ciavoi, Gabriela, Iova, Gilda, Ganea, Mariana, Scrobotă, Ioana
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.11.2021
MDPI
Subjects
Animals
anti-inflammatory
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - therapeutic use
Antidiabetics
Antimicrobial agents
antioxidant
Antioxidants
Antioxidants - chemistry
Antioxidants - therapeutic use
Bacteria
Bibliometrics
Biphenyl Compounds - chemistry
Biphenyl Compounds - therapeutic use
Cardiovascular disease
carvacrol
Citations
Cymenes - chemistry
Cymenes - therapeutic use
Diabetes
Diabetes Mellitus - drug therapy
Diabetes Mellitus - metabolism
Gum disease
Humans
Impact factors
Inflammatory diseases
Insulin
Lignans - chemistry
Lignans - therapeutic use
Magnolia - chemistry
magnolol
Origanum - chemistry
Pathogenesis
Pathogens
Pathology
periodontitis
Periodontitis - drug therapy
Periodontitis - metabolism
Periodontium
Review
anti-osteoclastic
toxicity
antimicrobial
antioxidant
magnolol
periodontitis
anti-inflammatory
anti-diabetic
carvacrol
diabetes
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Abstract Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.
AbstractList Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.
Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.
Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare . Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis , mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.
Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is . Magnolol is a traditional polyphenolic compound isolated from the stem bark of , mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.
Author Babes, Petru
Popa, Adelina
Iova, Gilda
Scrobotă, Ioana
Ganea, Mariana
Ciavoi, Gabriela
Cicalău, Georgiana
Calniceanu, Horia
AuthorAffiliation 1 Doctoral School of Biomedical Science, University of Oradea, 1st University Street, 410087 Oradea, Romania; cicalau.georgiana@gmail.com
5 Department of Orthodontics, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
7 Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, Romania; madafarm2005@yahoo.com
6 Orthodontic Research Center (ORTHO-CENTER), Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
4 Periodontal and Periimplant Diseases Research Center “Prof. Dr. Anton Sculean”, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
3 Department of Periodontology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
2 Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, Romania; gcia
AuthorAffiliation_xml – name: 6 Orthodontic Research Center (ORTHO-CENTER), Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
– name: 7 Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, Romania; madafarm2005@yahoo.com
– name: 3 Department of Periodontology, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
– name: 1 Doctoral School of Biomedical Science, University of Oradea, 1st University Street, 410087 Oradea, Romania; cicalau.georgiana@gmail.com
– name: 4 Periodontal and Periimplant Diseases Research Center “Prof. Dr. Anton Sculean”, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
– name: 2 Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, Romania; gciavoi@uoradea.ro (G.C.); gilda_iova@yahoo.ro (G.M.I.); ioana_scrobota@yahoo.com (I.S.)
– name: 5 Department of Orthodontics, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
Author_xml – sequence: 1
  givenname: Georgiana
  orcidid: 0000-0002-8412-104X
  surname: Cicalău
  fullname: Cicalău, Georgiana
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  givenname: Adelina
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  fullname: Popa, Adelina
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  orcidid: 0000-0003-1417-5963
  surname: Ciavoi
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  surname: Iova
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  givenname: Ioana
  orcidid: 0000-0002-2643-761X
  surname: Scrobotă
  fullname: Scrobotă, Ioana
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34833990$$D View this record in MEDLINE/PubMed
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Issue 22
Keywords anti-osteoclastic
toxicity
antimicrobial
antioxidant
magnolol
periodontitis
anti-inflammatory
anti-diabetic
carvacrol
diabetes
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
This author died in accident.
These authors contributed equally to this work.
ORCID 0000-0002-2643-761X
0000-0002-8412-104X
0000-0003-1417-5963
OpenAccessLink https://doaj.org/article/296660bef2f74cfca7bf81f983503945
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Snippet Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol...
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SubjectTerms Animals
anti-inflammatory
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - therapeutic use
Antidiabetics
Antimicrobial agents
antioxidant
Antioxidants
Antioxidants - chemistry
Antioxidants - therapeutic use
Bacteria
Bibliometrics
Biphenyl Compounds - chemistry
Biphenyl Compounds - therapeutic use
Cardiovascular disease
carvacrol
Citations
Cymenes - chemistry
Cymenes - therapeutic use
Diabetes
Diabetes Mellitus - drug therapy
Diabetes Mellitus - metabolism
Gum disease
Humans
Impact factors
Inflammatory diseases
Insulin
Lignans - chemistry
Lignans - therapeutic use
Magnolia - chemistry
magnolol
Origanum - chemistry
Pathogenesis
Pathogens
Pathology
periodontitis
Periodontitis - drug therapy
Periodontitis - metabolism
Periodontium
Review
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Title Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
URI https://www.ncbi.nlm.nih.gov/pubmed/34833990
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Volume 26
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