Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis[S]

• Published in: Journal of lipid research Vol. 56; no. 4; pp. 909 - 919
• Main Authors: Xie, Letian X., Williams, Kevin J., He, Cuiwen H., Weng, Emily, Khong, San, Rose, Tristan E., Kwon, Ohyun, Bensinger, Steven J., Marbois, Beth N., Clarke, Catherine F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Animals; antioxidants; Cell Line, Tumor; Coumaric Acids - metabolism; Escherichia coli - metabolism; Humans; isoprenoids; lipids/chemistry; mass spectrometry; Mice; mitochondria; plant polyphenols; Propionates; Resveratrol; Saccharomyces cerevisiae - metabolism; stilbene; Stilbenes - metabolism; ubiquinone; Ubiquinone - biosynthesis; Ubiquinone - chemistry; ubiquinone; plant polyphenols; antioxidants; isoprenoids; lipids/chemistry; mitochondria; stilbene; mass spectrometry

Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the...