Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis[S]
Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the...
Saved in:
| Published in | Journal of lipid research Vol. 56; no. 4; pp. 909 - 919 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.04.2015
The American Society for Biochemistry and Molecular Biology Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the recent finding that para-aminobenzoic acid (pABA) also serves as a ring precursor in Saccharomyces cerevisiae Q biosynthesis. In this study, we employed aromatic 13C6-ring-labeled compounds including 13C6-4HB, 13C6-pABA, 13C6-resveratrol, and 13C6-coumarate to investigate the role of these small molecules as aromatic ring precursors in Q biosynthesis in Escherichia coli, S. cerevisiae, and human and mouse cells. In contrast to S. cerevisiae, neither E. coli nor the mammalian cells tested were able to form 13C6-Q when cultured in the presence of 13C6-pABA. However, E. coli cells treated with 13C6-pABA generated 13C6-ring-labeled forms of 3-octaprenyl-4-aminobenzoic acid, 2-octaprenyl-aniline, and 3-octaprenyl-2-aminophenol, suggesting UbiA, UbiD, UbiX, and UbiI are capable of using pABA or pABA-derived intermediates as substrates. E. coli, S. cerevisiae, and human and mouse cells cultured in the presence of 13C6-resveratrol or 13C6-coumarate were able to synthesize 13C6-Q. Future evaluation of the physiological and pharmacological responses to dietary polyphenols should consider their metabolism to Q. |
|---|---|
| AbstractList | Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the recent finding that para-aminobenzoic acid (pABA) also serves as a ring precursor in Saccharomyces cerevisiae Q biosynthesis. In this study, we employed aromatic 13C6-ring-labeled compounds including 13C6-4HB, 13C6-pABA, 13C6-resveratrol, and 13C6-coumarate to investigate the role of these small molecules as aromatic ring precursors in Q biosynthesis in Escherichia coli, S. cerevisiae, and human and mouse cells. In contrast to S. cerevisiae, neither E. coli nor the mammalian cells tested were able to form 13C6-Q when cultured in the presence of 13C6-pABA. However, E. coli cells treated with 13C6-pABA generated 13C6-ring-labeled forms of 3-octaprenyl-4-aminobenzoic acid, 2-octaprenyl-aniline, and 3-octaprenyl-2-aminophenol, suggesting UbiA, UbiD, UbiX, and UbiI are capable of using pABA or pABA-derived intermediates as substrates. E. coli, S. cerevisiae, and human and mouse cells cultured in the presence of 13C6-resveratrol or 13C6-coumarate were able to synthesize 13C6-Q. Future evaluation of the physiological and pharmacological responses to dietary polyphenols should consider their metabolism to Q. Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the recent finding that para-aminobenzoic acid (pABA) also serves as a ring precursor in Saccharomyces cerevisiae Q biosynthesis. In this study, we employed aromatic (13)C6-ring-labeled compounds including (13)C6-4HB, (13)C6-pABA, (13)C6-resveratrol, and (13)C6-coumarate to investigate the role of these small molecules as aromatic ring precursors in Q biosynthesis in Escherichia coli, S. cerevisiae, and human and mouse cells. In contrast to S. cerevisiae, neither E. coli nor the mammalian cells tested were able to form (13)C6-Q when cultured in the presence of (13)C6-pABA. However, E. coli cells treated with (13)C6-pABA generated (13)C6-ring-labeled forms of 3-octaprenyl-4-aminobenzoic acid, 2-octaprenyl-aniline, and 3-octaprenyl-2-aminophenol, suggesting UbiA, UbiD, UbiX, and UbiI are capable of using pABA or pABA-derived intermediates as substrates. E. coli, S. cerevisiae, and human and mouse cells cultured in the presence of (13)C6-resveratrol or (13)C6-coumarate were able to synthesize (13)C6-Q. Future evaluation of the physiological and pharmacological responses to dietary polyphenols should consider their metabolism to Q. Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the recent finding that para -aminobenzoic acid (pABA) also serves as a ring precursor in Saccharomyces cerevisiae Q biosynthesis. In this study, we employed aromatic 13 C 6 -ring-labeled compounds including 13 C 6 -4HB, 13 C 6 -pABA, 13 C 6 -resveratrol, and 13 C 6 -coumarate to investigate the role of these small molecules as aromatic ring precursors in Q biosynthesis in Escherichia coli, S. cerevisiae , and human and mouse cells. In contrast to S. cerevisiae , neither E. coli nor the mammalian cells tested were able to form 13 C 6 -Q when cultured in the presence of 13 C 6 -pABA. However, E. coli cells treated with 13 C 6 -pABA generated 13 C 6 -ring-labeled forms of 3-octaprenyl-4-aminobenzoic acid, 2-octaprenyl-aniline, and 3-octaprenyl-2-aminophenol, suggesting UbiA, UbiD, UbiX, and UbiI are capable of using pABA or pABA-derived intermediates as substrates. E. coli, S. cerevisiae, and human and mouse cells cultured in the presence of 13 C 6 -resveratrol or 13 C 6 -coumarate were able to synthesize 13 C 6 -Q. Future evaluation of the physiological and pharmacological responses to dietary polyphenols should consider their metabolism to Q. Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the recent finding that para-aminobenzoic acid (pABA) also serves as a ring precursor in Saccharomyces cerevisiae Q biosynthesis. In this study, we employed aromatic (13)C6-ring-labeled compounds including (13)C6-4HB, (13)C6-pABA, (13)C6-resveratrol, and (13)C6-coumarate to investigate the role of these small molecules as aromatic ring precursors in Q biosynthesis in Escherichia coli, S. cerevisiae, and human and mouse cells. In contrast to S. cerevisiae, neither E. coli nor the mammalian cells tested were able to form (13)C6-Q when cultured in the presence of (13)C6-pABA. However, E. coli cells treated with (13)C6-pABA generated (13)C6-ring-labeled forms of 3-octaprenyl-4-aminobenzoic acid, 2-octaprenyl-aniline, and 3-octaprenyl-2-aminophenol, suggesting UbiA, UbiD, UbiX, and UbiI are capable of using pABA or pABA-derived intermediates as substrates. E. coli, S. cerevisiae, and human and mouse cells cultured in the presence of (13)C6-resveratrol or (13)C6-coumarate were able to synthesize (13)C6-Q. Future evaluation of the physiological and pharmacological responses to dietary polyphenols should consider their metabolism to Q.Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. The aromatic ring 4-hydroxybenzoic acid (4HB) is commonly depicted as the sole aromatic ring precursor in Q biosynthesis despite the recent finding that para-aminobenzoic acid (pABA) also serves as a ring precursor in Saccharomyces cerevisiae Q biosynthesis. In this study, we employed aromatic (13)C6-ring-labeled compounds including (13)C6-4HB, (13)C6-pABA, (13)C6-resveratrol, and (13)C6-coumarate to investigate the role of these small molecules as aromatic ring precursors in Q biosynthesis in Escherichia coli, S. cerevisiae, and human and mouse cells. In contrast to S. cerevisiae, neither E. coli nor the mammalian cells tested were able to form (13)C6-Q when cultured in the presence of (13)C6-pABA. However, E. coli cells treated with (13)C6-pABA generated (13)C6-ring-labeled forms of 3-octaprenyl-4-aminobenzoic acid, 2-octaprenyl-aniline, and 3-octaprenyl-2-aminophenol, suggesting UbiA, UbiD, UbiX, and UbiI are capable of using pABA or pABA-derived intermediates as substrates. E. coli, S. cerevisiae, and human and mouse cells cultured in the presence of (13)C6-resveratrol or (13)C6-coumarate were able to synthesize (13)C6-Q. Future evaluation of the physiological and pharmacological responses to dietary polyphenols should consider their metabolism to Q. |
| Author | Marbois, Beth N. Khong, San Kwon, Ohyun Bensinger, Steven J. Rose, Tristan E. He, Cuiwen H. Weng, Emily Xie, Letian X. Williams, Kevin J. Clarke, Catherine F. |
| Author_xml | – sequence: 1 givenname: Letian X. surname: Xie fullname: Xie, Letian X. organization: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569 – sequence: 2 givenname: Kevin J. surname: Williams fullname: Williams, Kevin J. organization: Departments of Microbiology, Immunology, and Molecular Genetics University of California, Los Angeles, CA 90095-1569 – sequence: 3 givenname: Cuiwen H. surname: He fullname: He, Cuiwen H. organization: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569 – sequence: 4 givenname: Emily surname: Weng fullname: Weng, Emily organization: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569 – sequence: 5 givenname: San surname: Khong fullname: Khong, San organization: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569 – sequence: 6 givenname: Tristan E. surname: Rose fullname: Rose, Tristan E. organization: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569 – sequence: 7 givenname: Ohyun surname: Kwon fullname: Kwon, Ohyun organization: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569 – sequence: 8 givenname: Steven J. surname: Bensinger fullname: Bensinger, Steven J. organization: Departments of Microbiology, Immunology, and Molecular Genetics University of California, Los Angeles, CA 90095-1569 – sequence: 9 givenname: Beth N. surname: Marbois fullname: Marbois, Beth N. organization: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569 – sequence: 10 givenname: Catherine F. surname: Clarke fullname: Clarke, Catherine F. email: cathy@chem.ucla.edu organization: Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25681964$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kd1rFDEUxYNU7Lb65LvkUZCp-ZxMXgQpfhQq4ueLSMhk72yzzCbbJLOw_eubdddiRZ8uJOece5LfCToKMQBCTyk5o1SLl8sxnX0gUmmqH6AZlVw3irXsCM0IYaxhTMljdJLzkhAqREsfoWMm247qVszQ98-QN5BsSXHENszx2ibbuDit6iyAM6QNYJtx8mGB1wnclHJMGQ8xYRch3GxXgD_h3se8DeUKss8_vvx8jB4Odszw5DBP0be3b76ev28uP767OH992TgpdWnE4HpgnZWt1BR60gsi5KAkoS3nANrRjhMBigvO9SCIsqCl7rUjQJSGjp-ii33uPNqlWSdfa29NtN78OohpYWwq3o1gbH295JzxulP0ndJyLpTlg-wF7TUVNevVPms99SuYOwgl2fFe6P2b4K_MIm6M4IoroWrA80NAitcT5GJWPjsYRxsgTtnQtu0Y7yjf9X725667Jb_BVMGLvcClmHOC4U5CidlhNxW7OWCvavqX2vlii4-7on78j0fuPVD5bDwkk52H4GDuK-VSP9D_03cLumXDQw |
| CitedBy_id | crossref_primary_10_1038_s41589_023_01452_w crossref_primary_10_1016_j_freeradbiomed_2017_06_006 crossref_primary_10_3389_fphys_2017_00463 crossref_primary_10_1016_j_bbabio_2020_148259 crossref_primary_10_1016_j_bbalip_2015_05_003 crossref_primary_10_1021_acs_jnatprod_1c01107 crossref_primary_10_1021_acs_jafc_6b04346 crossref_primary_10_1152_physrev_00040_2023 crossref_primary_10_3390_nu11092221 crossref_primary_10_1016_j_freeradbiomed_2021_01_024 crossref_primary_10_3390_antiox12010123 crossref_primary_10_1016_j_microc_2023_109499 crossref_primary_10_3390_antiox11040665 crossref_primary_10_1016_j_tem_2019_08_009 crossref_primary_10_1016_j_jff_2024_106520 crossref_primary_10_3390_molecules25132955 crossref_primary_10_3390_biomedicines9101457 crossref_primary_10_3164_jcbn_24_70 crossref_primary_10_1016_j_phytochem_2019_02_011 crossref_primary_10_1042_EBC20170106 crossref_primary_10_3389_fphys_2017_00436 crossref_primary_10_1074_jbc_M115_675744 crossref_primary_10_1093_gbe_evx225 crossref_primary_10_1038_s41586_021_03865_w crossref_primary_10_1007_s00414_021_02640_w crossref_primary_10_1093_femsle_fnad050 crossref_primary_10_1007_s11274_022_03242_3 crossref_primary_10_2174_1389201023666220818085945 crossref_primary_10_3390_metabo11060385 crossref_primary_10_1016_j_freeradbiomed_2020_04_029 crossref_primary_10_1016_j_chembiol_2016_08_008 crossref_primary_10_3390_antiox9050431 crossref_primary_10_1016_j_jbc_2021_100643 crossref_primary_10_1128_spectrum_04835_22 |
| Cites_doi | 10.1074/jbc.M112.360354 10.1016/j.bbamem.2003.11.012 10.1093/gerona/glr062 10.1016/S0021-9258(18)51887-1 10.1126/science.277.5331.1453 10.1016/j.bbalip.2013.12.017 10.1016/j.chembiol.2010.03.014 10.1038/msb4100050 10.1002/biof.5520320111 10.1111/j.1749-6632.2010.05842.x 10.1152/ajprenal.00143.2013 10.1104/pp.106.1.271 10.1016/j.bbabio.2014.01.015 10.1158/1535-7163.MCT-04-0056 10.1074/jbc.M114.633131 10.1089/jmf.2010.0080 10.1093/hmg/ddt330 10.1016/j.chembiol.2011.07.008 10.1371/journal.pone.0059887 10.1016/j.fgb.2010.10.009 10.1007/BF01282151 10.1074/jbc.M110.151894 10.1016/j.cmet.2011.10.002 10.1016/j.abb.2007.08.009 10.1099/00221287-138-10-2101 10.1016/j.celrep.2014.12.048 10.1002/jlcr.869 10.1128/EC.00084-13 10.1128/jb.174.16.5309-5316.1992 10.1105/tpc.114.125807 10.1002/cbic.200700724 10.1016/j.febslet.2009.12.029 10.1016/j.mito.2007.03.007 10.1042/bj1230435 10.1096/fj.14-252411 10.1016/j.bbalip.2012.12.007 10.1038/nrd2060 10.2174/187152711798072310 10.1038/nchembio.372 10.1016/j.mito.2007.02.006 10.1073/pnas.81.15.4819 10.1038/nature10296 10.1016/j.bbalip.2011.04.010 10.1093/jb/mvp102 10.1016/j.bbabio.2010.06.007 10.1016/0003-9861(75)90022-3 10.1371/journal.pone.0019881 10.1016/S0083-6729(08)60431-8 10.1016/j.bbrc.2010.02.147 10.1074/jbc.M113.480368 10.1002/emmm.201100149 |
| ContentType | Journal Article |
| Copyright | 2015 © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc. Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc. 2015 |
| Copyright_xml | – notice: 2015 © 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. – notice: Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc. – notice: Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc. 2015 |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA |
| DOI | 10.1194/jlr.M057919 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1539-7262 |
| EndPage | 919 |
| ExternalDocumentID | oai_doaj_org_article_a01453323fcb4b8795d47a3f5b41b914 PMC4373747 25681964 10_1194_jlr_M057919 S0022227520355711 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCRR NIH HHS grantid: S10RR024605 – fundername: NIGMS NIH HHS grantid: R01 GM071779 – fundername: NIGMS NIH HHS grantid: R01GM071779 – fundername: NCRR NIH HHS grantid: S10 RR024605 – fundername: NIGMS NIH HHS grantid: T32 GM007185 |
| GroupedDBID | --- -~X .55 .GJ 0SF 0VX 18M 29K 2WC 34G 39C 4.4 53G 5GY 5RE 5VS 6I. AAEDW AAFTH AAFWJ AAXUO AAYOK ABCQX ABOCM ACCCW ACGFO ACKIV ACNCT ACPRK ADBBV AENEX AEXQZ AFFNX AFOSN AFPKN AHPSJ AI. ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BTFSW C1A CS3 D-I DIK DU5 E3Z EBS EJD F5P FDB FRP GROUPED_DOAJ GX1 H13 HH5 HYE H~9 J5H KQ8 L7B MVM OK1 P2P RHF RHI ROL RPM TBC TR2 TWZ VH1 W8F WH7 WOQ X7M XFK YHG YKV ZA5 ZGI ZXP ~KM 0R~ AALRI AAYWO AAYXX ACVFH ADCNI ADVLN AEUPX AFPUW AIGII AITUG AKBMS AKRWK AKYEP CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c559t-4fcbe28a56591eb0b4045f7501633ee9c18304e734339f407ae959b9c0e079e83 |
| IEDL.DBID | DOA |
| ISSN | 0022-2275 1539-7262 |
| IngestDate | Wed Aug 27 01:28:19 EDT 2025 Thu Aug 21 13:47:18 EDT 2025 Mon Jul 21 10:08:13 EDT 2025 Mon Jul 21 06:09:37 EDT 2025 Thu Apr 24 22:54:00 EDT 2025 Tue Jul 01 01:14:32 EDT 2025 Fri Feb 23 02:45:47 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | ubiquinone plant polyphenols antioxidants isoprenoids lipids/chemistry mitochondria stilbene mass spectrometry |
| Language | English |
| License | This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0 https://www.elsevier.com/tdm/userlicense/1.0 Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c559t-4fcbe28a56591eb0b4045f7501633ee9c18304e734339f407ae959b9c0e079e83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/a01453323fcb4b8795d47a3f5b41b914 |
| PMID | 25681964 |
| PQID | 1668238138 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_a01453323fcb4b8795d47a3f5b41b914 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4373747 proquest_miscellaneous_1668238138 pubmed_primary_25681964 crossref_primary_10_1194_jlr_M057919 crossref_citationtrail_10_1194_jlr_M057919 elsevier_sciencedirect_doi_10_1194_jlr_M057919 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | April 2015 2015-04-00 2015-Apr 20150401 2015-04-01 |
| PublicationDateYYYYMMDD | 2015-04-01 |
| PublicationDate_xml | – month: 04 year: 2015 text: April 2015 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of lipid research |
| PublicationTitleAlternate | J Lipid Res |
| PublicationYear | 2015 |
| Publisher | Elsevier Inc The American Society for Biochemistry and Molecular Biology Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: The American Society for Biochemistry and Molecular Biology – name: Elsevier |
| References | Falk, Polyak, Zhang, Peng, King, Maltzman, Okwuego, Horyn, Nakamaru-Ogiso, Ostrovsky (bib28) 2011; 3 Lobo, Amengual, Palczewski, Babino, von Lintig (bib43) 2012; 1821 Baur, Sinclair (bib37) 2006; 5 Burnett, Valentini, Cabreiro, Goss, Somogyvari, Piper, Hoddinott, Sutphin, Leko, McElwee (bib39) 2011; 477 Diaz-Sánchez, Estrada, Limon, Al-Babili, Avalos (bib46) 2013; 12 Vang, Ahmad, Baile, Baur, Brown, Csiszar, Das, Delmas, Gottfried, Lin (bib41) 2011; 6 Palczewski, Amengual, Hoppel, von Lintig (bib44) 2014; 28 Tran, Clarke (bib12) 2007; 7 Marbois, Xie, Choi, Hirano, Hyman, Clarke (bib18) 2010; 285 Yaffe, Schatz (bib25) 1984; 81 Gulmezian, Hyman, Marbois, Clarke, Javor (bib30) 2007; 467 Timmers, Konings, Bilet, Houtkooper, van de Weijer, Goossens, Hoeks, van der Krieken, Ryu, Kersten (bib38) 2011; 14 BurkeD. J.AmbergD. C.StrathernJ. N.. 2005. Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual. Cold Spring Harbor Laboratory Press, Plainview, NY. Wu, Williams, Zamanian, Gibson, Poole (bib52) 1992; 138 Robbins, Schmidt (bib26) 2004; 47 Hajj Chehade, Loiseau, Lombard, Pecqueur, Ismail, Smadja, Golinelli-Pimpaneau, Mellot-Draznieks, Hamelin, Aussel (bib31) 2013; 288 Nichols, Green (bib22) 1992; 174 Wang, Hekimi (bib10) 2013; 22 Ozeir, Muhlenhoff, Webert, Lill, Fontecave, Pierrel (bib49) 2011; 18 Anderson, Kazantzis, Wang, Venkatraman, Goncalves, Quinlan, Ng, Jastroch, Benjamin, Nie (bib8) 2015; 10 Forsman, Sjoberg, Turunen, Sindelar (bib34) 2010; 6 Bentinger, Brismar, Dallner (bib3) 2007; 7 Jiang, Zhang, Kuo, Kuo, Gautam, Groc, Rodriguez, Koubi, Hunter, Corcoran (bib42) 2005; 4 Brefort, Scherzinger, Limon, Estrada, Trautmann, Mengel, Avalos, Al-Babili (bib48) 2011; 48 Schmelzer, Kohl, Rimbach, Doring (bib51) 2011; 14 Marasco, Schmidt-Dannert (bib45) 2008; 9 Inaba (bib6) 2009; 146 Xie, Ozeir, Tang, Chen, Jaquinod, Fontecave, Clarke, Pierrel (bib11) 2012; 287 Turunen, Olsson, Dallner (bib4) 2004; 1660 Loscher, Heide (bib35) 1994; 106 Matsuo, Nishino, Mizuno, Akihiro, Toda, Matsuo, Kaino, Kawamukai (bib5) 2013; 8 Allan, Awad, Johnson, Shirasaki, Wang, Blaby-Haas, Merchant, Loo, Clarke (bib14) 2015; 290 Walle (bib50) 2011; 1215 Alam, Nambudiri, Rudney (bib32) 1975; 171 He, Xie, Allan, Tran, Clarke (bib19) 2014; 1841 Foti Cuzzola, Ciurleo, Giacoppo, Marino, Bramanti (bib47) 2011; 10 Olson, Bentley, Aiyar, Dialameh, Gold, Ramsey, Springer (bib23) 1963; 238 Smoliga, Vang, Baur (bib40) 2012; 67 Hamilton, Cox (bib33) 1971; 123 Zhang, Wakitani, Hayashi, Miki, Kawamukai (bib7) 2008; 32 Aussel, Pierrel, Loiseau, Lombard, Fontecave, Barras (bib21) 2014; 1837 Olson, Rudney (bib17) 1983; 40 Gasser, Winkler, Peng, An, McKenzie, Kirk, Shi, Xie, Marbois, Clarke (bib29) 2013; 305 Bentinger, Tekle, Dallner (bib1) 2010; 396 Allan, Hill, Morvaridi, Saiki, Johnson, Liau, Hirano, Kawashima, Ji, Loo (bib13) 2013; 1831 LikhtenshteinG.. 2010. Stilbenes: Applications in Chemistry, Life Sciences and Materials Science. 1st edition. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. Clarke (bib16) 2000; 213 Nowicka, Kruk (bib2) 2010; 1797 Pierrel, Hamelin, Douki, Kieffer-Jaquinod, Muhlenhoff, Ozeir, Lill, Fontecave (bib9) 2010; 17 Cui, Kaino, Kawamukai (bib20) 2010; 584 Baba, Ara, Hasegawa, Takai, Okumura, Baba, Datsenko, Tomita, Wanner, Mori (bib27) 2006; 2 Block, Widhalm, Fatihi, Cahoon, Wamboldt, Elowsky, Mackenzie, Cahoon, Chapple, Dudareva (bib15) 2014; 26 Blattner, Plunkett, Bloch, Perna, Burland, Riley, Collado-Vides, Glasner, Rode, Mayhew (bib53) 1997; 277 Allan (10.1194/jlr.M057919_bib13) 2013; 1831 Turunen (10.1194/jlr.M057919_bib4) 2004; 1660 Lobo (10.1194/jlr.M057919_bib43) 2012; 1821 Ozeir (10.1194/jlr.M057919_bib49) 2011; 18 Olson (10.1194/jlr.M057919_bib23) 1963; 238 Pierrel (10.1194/jlr.M057919_bib9) 2010; 17 Gulmezian (10.1194/jlr.M057919_bib30) 2007; 467 Clarke (10.1194/jlr.M057919_bib16) 2000; 213 Nichols (10.1194/jlr.M057919_bib22) 1992; 174 Yaffe (10.1194/jlr.M057919_bib25) 1984; 81 Allan (10.1194/jlr.M057919_bib14) 2015; 290 Vang (10.1194/jlr.M057919_bib41) 2011; 6 Bentinger (10.1194/jlr.M057919_bib3) 2007; 7 10.1194/jlr.M057919_bib24 Forsman (10.1194/jlr.M057919_bib34) 2010; 6 Hamilton (10.1194/jlr.M057919_bib33) 1971; 123 Marbois (10.1194/jlr.M057919_bib18) 2010; 285 Gasser (10.1194/jlr.M057919_bib29) 2013; 305 Schmelzer (10.1194/jlr.M057919_bib51) 2011; 14 Zhang (10.1194/jlr.M057919_bib7) 2008; 32 Olson (10.1194/jlr.M057919_bib17) 1983; 40 Cui (10.1194/jlr.M057919_bib20) 2010; 584 Hajj Chehade (10.1194/jlr.M057919_bib31) 2013; 288 Baur (10.1194/jlr.M057919_bib37) 2006; 5 Block (10.1194/jlr.M057919_bib15) 2014; 26 Blattner (10.1194/jlr.M057919_bib53) 1997; 277 Bentinger (10.1194/jlr.M057919_bib1) 2010; 396 Baba (10.1194/jlr.M057919_bib27) 2006; 2 Falk (10.1194/jlr.M057919_bib28) 2011; 3 Palczewski (10.1194/jlr.M057919_bib44) 2014; 28 10.1194/jlr.M057919_bib36 Tran (10.1194/jlr.M057919_bib12) 2007; 7 Diaz-Sánchez (10.1194/jlr.M057919_bib46) 2013; 12 Robbins (10.1194/jlr.M057919_bib26) 2004; 47 Alam (10.1194/jlr.M057919_bib32) 1975; 171 Inaba (10.1194/jlr.M057919_bib6) 2009; 146 Brefort (10.1194/jlr.M057919_bib48) 2011; 48 Nowicka (10.1194/jlr.M057919_bib2) 2010; 1797 Timmers (10.1194/jlr.M057919_bib38) 2011; 14 Wang (10.1194/jlr.M057919_bib10) 2013; 22 Loscher (10.1194/jlr.M057919_bib35) 1994; 106 Anderson (10.1194/jlr.M057919_bib8) 2015; 10 Burnett (10.1194/jlr.M057919_bib39) 2011; 477 Foti Cuzzola (10.1194/jlr.M057919_bib47) 2011; 10 Wu (10.1194/jlr.M057919_bib52) 1992; 138 He (10.1194/jlr.M057919_bib19) 2014; 1841 Aussel (10.1194/jlr.M057919_bib21) 2014; 1837 Xie (10.1194/jlr.M057919_bib11) 2012; 287 Walle (10.1194/jlr.M057919_bib50) 2011; 1215 Smoliga (10.1194/jlr.M057919_bib40) 2012; 67 Jiang (10.1194/jlr.M057919_bib42) 2005; 4 Marasco (10.1194/jlr.M057919_bib45) 2008; 9 Matsuo (10.1194/jlr.M057919_bib5) 2013; 8 |
| References_xml | – volume: 5 start-page: 493 year: 2006 end-page: 506 ident: bib37 article-title: Therapeutic potential of resveratrol: the in vivo evidence publication-title: Nat. Rev. Drug Discov. – volume: 213 start-page: 134 year: 2000 end-page: 147 ident: bib16 article-title: New advances in coenzyme Q biosynthesis publication-title: Protoplasma. – volume: 1660 start-page: 171 year: 2004 end-page: 199 ident: bib4 article-title: Metabolism and function of coenzyme Q publication-title: Biochim. Biophys. Acta. – volume: 14 start-page: 391 year: 2011 end-page: 397 ident: bib51 article-title: The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells publication-title: J. Med. Food. – volume: 4 start-page: 554 year: 2005 end-page: 561 ident: bib42 article-title: Resveratrol-induced apoptotic death in human U251 glioma cells publication-title: Mol. Cancer Ther. – volume: 81 start-page: 4819 year: 1984 end-page: 4823 ident: bib25 article-title: Two nuclear mutations that block mitochondrial protein import in yeast publication-title: Proc. Natl. Acad. Sci. USA. – volume: 277 start-page: 1453 year: 1997 end-page: 1462 ident: bib53 article-title: The complete genome sequence of publication-title: Science. – volume: 8 start-page: e59887 year: 2013 ident: bib5 article-title: Polypeptone induces dramatic cell lysis in publication-title: PLoS ONE. – volume: 17 start-page: 449 year: 2010 end-page: 459 ident: bib9 article-title: Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis publication-title: Chem. Biol. – volume: 32 start-page: 91 year: 2008 end-page: 98 ident: bib7 article-title: High production of sulfide in coenzyme Q deficient fission yeast publication-title: Biofactors. – volume: 305 start-page: F1228 year: 2013 end-page: F1238 ident: bib29 article-title: Focal segmental glomerulosclerosis is associated with a publication-title: Am. J. Physiol. Renal Physiol. – volume: 138 start-page: 2101 year: 1992 end-page: 2112 ident: bib52 article-title: Isolation and characterization of publication-title: J. Gen. Microbiol. – volume: 18 start-page: 1134 year: 2011 end-page: 1142 ident: bib49 article-title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue publication-title: Chem. Biol. – volume: 171 start-page: 183 year: 1975 end-page: 190 ident: bib32 article-title: 4-Hydroxybenzoate: polyprenyl transferase and the prenylation of 4-aminobenzoate in mammalian tissues publication-title: Arch. Biochem. Biophys. – volume: 123 start-page: 435 year: 1971 end-page: 443 ident: bib33 article-title: Ubiquinone biosynthesis in publication-title: Biochem. J. – volume: 146 start-page: 591 year: 2009 end-page: 597 ident: bib6 article-title: Disulfide bond formation system in publication-title: J. Biochem. – volume: 47 start-page: 797 year: 2004 end-page: 806 ident: bib26 article-title: Optimized synthesis of four isotopically labeled ( publication-title: J. Labelled Comp. Radiopharm. – volume: 1837 start-page: 1004 year: 2014 end-page: 1011 ident: bib21 article-title: Biosynthesis and physiology of coenzyme Q in bacteria publication-title: Biochim. Biophys. Acta. – volume: 6 start-page: 515 year: 2010 end-page: 517 ident: bib34 article-title: 4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures publication-title: Nat. Chem. Biol. – volume: 10 start-page: 849 year: 2011 end-page: 862 ident: bib47 article-title: Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: focus on recent discoveries publication-title: CNS Neurol. Disord. Drug Targets. – volume: 174 start-page: 5309 year: 1992 end-page: 5316 ident: bib22 article-title: Cloning and sequencing of publication-title: J. Bacteriol. – reference: BurkeD. J.AmbergD. C.StrathernJ. N.. 2005. Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual. Cold Spring Harbor Laboratory Press, Plainview, NY. – volume: 28 start-page: 4457 year: 2014 end-page: 4469 ident: bib44 article-title: Evidence for compartmentalization of mammalian carotenoid metabolism publication-title: FASEB J. – volume: 288 start-page: 20085 year: 2013 end-page: 20092 ident: bib31 article-title: , a new gene in publication-title: J. Biol. Chem. – volume: 285 start-page: 27827 year: 2010 end-page: 27838 ident: bib18 article-title: para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in publication-title: J. Biol. Chem. – volume: 584 start-page: 652 year: 2010 end-page: 656 ident: bib20 article-title: A subunit of decaprenyl diphosphate synthase stabilizes octaprenyl diphosphate synthase in publication-title: FEBS Lett. – volume: 7 start-page: S41 year: 2007 end-page: S50 ident: bib3 article-title: The antioxidant role of coenzyme Q publication-title: Mitochondrion. – volume: 1797 start-page: 1587 year: 2010 end-page: 1605 ident: bib2 article-title: Occurrence, biosynthesis and function of isoprenoid quinones publication-title: Biochim. Biophys. Acta. – volume: 14 start-page: 612 year: 2011 end-page: 622 ident: bib38 article-title: Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans publication-title: Cell Metab. – volume: 12 start-page: 1305 year: 2013 end-page: 1314 ident: bib46 article-title: The oxygenase CAO-1 of Neurospora crassa is a resveratrol cleavage enzyme publication-title: Eukaryot. Cell. – volume: 1831 start-page: 776 year: 2013 end-page: 791 ident: bib13 article-title: A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae publication-title: Biochim. Biophys. Acta. – volume: 26 start-page: 1938 year: 2014 end-page: 1948 ident: bib15 article-title: The origin and biosynthesis of the benzenoid moiety of ubiquinone (coenzyme Q) in publication-title: Plant Cell. – volume: 22 start-page: 4768 year: 2013 end-page: 4783 ident: bib10 article-title: Mitochondrial respiration without ubiquinone biosynthesis publication-title: Hum. Mol. Genet. – volume: 396 start-page: 74 year: 2010 end-page: 79 ident: bib1 article-title: Coenzyme Q–biosynthesis and functions publication-title: Biochem. Biophys. Res. Commun. – volume: 1215 start-page: 9 year: 2011 end-page: 15 ident: bib50 article-title: Bioavailability of resveratrol publication-title: Ann. N. Y. Acad. Sci. – volume: 10 start-page: 505 year: 2015 end-page: 515 ident: bib8 article-title: Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake publication-title: Cell Reports. – volume: 238 start-page: 3146 year: 1963 end-page: 3148 ident: bib23 article-title: Benzoate Derivatives as Intermediates in the Biosynthesis of Coenzyme Q in the Rat publication-title: J. Biol. Chem. – volume: 467 start-page: 144 year: 2007 end-page: 153 ident: bib30 article-title: The role of UbiX in publication-title: Arch. Biochem. Biophys. – volume: 9 start-page: 1450 year: 2008 end-page: 1461 ident: bib45 article-title: Identification of bacterial carotenoid cleavage dioxygenase homologues that cleave the interphenyl alpha,beta double bond of stilbene derivatives via a monooxygenase reaction publication-title: ChemBioChem. – volume: 3 start-page: 410 year: 2011 end-page: 427 ident: bib28 article-title: Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in publication-title: EMBO Mol. Med. – volume: 1821 start-page: 78 year: 2012 end-page: 87 ident: bib43 article-title: Mammalian carotenoid-oxygenases: key players for carotenoid function and homeostasis publication-title: Biochim. Biophys. Acta. – volume: 287 start-page: 23571 year: 2012 end-page: 23581 ident: bib11 article-title: Overexpression of the Coq8 kinase in publication-title: J. Biol. Chem. – volume: 2 start-page: 2006.0008 year: 2006 ident: bib27 article-title: Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection publication-title: Mol. Syst. Biol. – volume: 67 start-page: 158 year: 2012 end-page: 167 ident: bib40 article-title: Challenges of translating basic research into therapeutics: resveratrol as an example publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 40 start-page: 1 year: 1983 end-page: 43 ident: bib17 article-title: Biosynthesis of ubiquinone publication-title: Vitam. Horm. – volume: 106 start-page: 271 year: 1994 end-page: 279 ident: bib35 article-title: Biosynthesis of p-Hydroxybenzoate from p-Coumarate and p-Coumaroyl-Coenzyme A in cell-free extracts of publication-title: Plant Physiol. – volume: 48 start-page: 132 year: 2011 end-page: 143 ident: bib48 article-title: Cleavage of resveratrol in fungi: characterization of the enzyme Rco1 from publication-title: Fungal Genet. Biol. – volume: 7 start-page: S62 year: 2007 end-page: S71 ident: bib12 article-title: Endogenous synthesis of coenzyme Q in eukaryotes publication-title: Mitochondrion. – volume: 1841 start-page: 630 year: 2014 end-page: 644 ident: bib19 article-title: Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast publication-title: Biochim. Biophys. Acta. – reference: .LikhtenshteinG.. 2010. Stilbenes: Applications in Chemistry, Life Sciences and Materials Science. 1st edition. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. – volume: 6 start-page: e19881 year: 2011 ident: bib41 article-title: What is new for an old molecule? Systematic review and recommendations on the use of resveratrol publication-title: PLoS ONE. – volume: 290 year: 2015 ident: bib14 article-title: Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae publication-title: J. Biol. Chem. – volume: 477 start-page: 482 year: 2011 end-page: 485 ident: bib39 article-title: Absence of effects of Sir2 overexpression on lifespan in publication-title: Nature. – volume: 287 start-page: 23571 year: 2012 ident: 10.1194/jlr.M057919_bib11 article-title: Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112.360354 – volume: 1660 start-page: 171 year: 2004 ident: 10.1194/jlr.M057919_bib4 article-title: Metabolism and function of coenzyme Q publication-title: Biochim. Biophys. Acta. doi: 10.1016/j.bbamem.2003.11.012 – volume: 67 start-page: 158 year: 2012 ident: 10.1194/jlr.M057919_bib40 article-title: Challenges of translating basic research into therapeutics: resveratrol as an example publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glr062 – volume: 238 start-page: 3146 year: 1963 ident: 10.1194/jlr.M057919_bib23 article-title: Benzoate Derivatives as Intermediates in the Biosynthesis of Coenzyme Q in the Rat publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)51887-1 – volume: 277 start-page: 1453 year: 1997 ident: 10.1194/jlr.M057919_bib53 article-title: The complete genome sequence of Escherichia coli K-12 publication-title: Science. doi: 10.1126/science.277.5331.1453 – volume: 1841 start-page: 630 year: 2014 ident: 10.1194/jlr.M057919_bib19 article-title: Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants publication-title: Biochim. Biophys. Acta. doi: 10.1016/j.bbalip.2013.12.017 – volume: 17 start-page: 449 year: 2010 ident: 10.1194/jlr.M057919_bib9 article-title: Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2010.03.014 – volume: 2 start-page: 2006.0008 year: 2006 ident: 10.1194/jlr.M057919_bib27 article-title: Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection publication-title: Mol. Syst. Biol. doi: 10.1038/msb4100050 – volume: 32 start-page: 91 year: 2008 ident: 10.1194/jlr.M057919_bib7 article-title: High production of sulfide in coenzyme Q deficient fission yeast publication-title: Biofactors. doi: 10.1002/biof.5520320111 – volume: 1215 start-page: 9 year: 2011 ident: 10.1194/jlr.M057919_bib50 article-title: Bioavailability of resveratrol publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2010.05842.x – volume: 305 start-page: F1228 year: 2013 ident: 10.1194/jlr.M057919_bib29 article-title: Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10 publication-title: Am. J. Physiol. Renal Physiol. doi: 10.1152/ajprenal.00143.2013 – ident: 10.1194/jlr.M057919_bib36 – volume: 106 start-page: 271 year: 1994 ident: 10.1194/jlr.M057919_bib35 article-title: Biosynthesis of p-Hydroxybenzoate from p-Coumarate and p-Coumaroyl-Coenzyme A in cell-free extracts of Lithospermum erythrorhizon cell cultures publication-title: Plant Physiol. doi: 10.1104/pp.106.1.271 – volume: 1837 start-page: 1004 year: 2014 ident: 10.1194/jlr.M057919_bib21 article-title: Biosynthesis and physiology of coenzyme Q in bacteria publication-title: Biochim. Biophys. Acta. doi: 10.1016/j.bbabio.2014.01.015 – volume: 4 start-page: 554 year: 2005 ident: 10.1194/jlr.M057919_bib42 article-title: Resveratrol-induced apoptotic death in human U251 glioma cells publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-04-0056 – volume: 290 year: 2015 ident: 10.1194/jlr.M057919_bib14 article-title: Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.633131 – ident: 10.1194/jlr.M057919_bib24 – volume: 14 start-page: 391 year: 2011 ident: 10.1194/jlr.M057919_bib51 article-title: The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells publication-title: J. Med. Food. doi: 10.1089/jmf.2010.0080 – volume: 22 start-page: 4768 year: 2013 ident: 10.1194/jlr.M057919_bib10 article-title: Mitochondrial respiration without ubiquinone biosynthesis publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddt330 – volume: 18 start-page: 1134 year: 2011 ident: 10.1194/jlr.M057919_bib49 article-title: Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue coq6 deficiency publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2011.07.008 – volume: 8 start-page: e59887 year: 2013 ident: 10.1194/jlr.M057919_bib5 article-title: Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeast publication-title: PLoS ONE. doi: 10.1371/journal.pone.0059887 – volume: 48 start-page: 132 year: 2011 ident: 10.1194/jlr.M057919_bib48 article-title: Cleavage of resveratrol in fungi: characterization of the enzyme Rco1 from Ustilago maydis. publication-title: Fungal Genet. Biol. doi: 10.1016/j.fgb.2010.10.009 – volume: 213 start-page: 134 year: 2000 ident: 10.1194/jlr.M057919_bib16 article-title: New advances in coenzyme Q biosynthesis publication-title: Protoplasma. doi: 10.1007/BF01282151 – volume: 285 start-page: 27827 year: 2010 ident: 10.1194/jlr.M057919_bib18 article-title: para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae. publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.151894 – volume: 14 start-page: 612 year: 2011 ident: 10.1194/jlr.M057919_bib38 article-title: Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans publication-title: Cell Metab. doi: 10.1016/j.cmet.2011.10.002 – volume: 467 start-page: 144 year: 2007 ident: 10.1194/jlr.M057919_bib30 article-title: The role of UbiX in Escherichia coli coenzyme Q biosynthesis publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2007.08.009 – volume: 138 start-page: 2101 year: 1992 ident: 10.1194/jlr.M057919_bib52 article-title: Isolation and characterization of Escherichia coli mutants affected in aerobic respiration: the cloning and nucleotide sequence of ubiG. Identification of an S-adenosylmethionine-binding motif in protein, RNA, and small-molecule methyltransferases publication-title: J. Gen. Microbiol. doi: 10.1099/00221287-138-10-2101 – volume: 10 start-page: 505 year: 2015 ident: 10.1194/jlr.M057919_bib8 article-title: Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake publication-title: Cell Reports. doi: 10.1016/j.celrep.2014.12.048 – volume: 47 start-page: 797 year: 2004 ident: 10.1194/jlr.M057919_bib26 article-title: Optimized synthesis of four isotopically labeled (13C-enriched) phenolic acids via a malonic acid condensation publication-title: J. Labelled Comp. Radiopharm. doi: 10.1002/jlcr.869 – volume: 12 start-page: 1305 year: 2013 ident: 10.1194/jlr.M057919_bib46 article-title: The oxygenase CAO-1 of Neurospora crassa is a resveratrol cleavage enzyme publication-title: Eukaryot. Cell. doi: 10.1128/EC.00084-13 – volume: 174 start-page: 5309 year: 1992 ident: 10.1194/jlr.M057919_bib22 article-title: Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase publication-title: J. Bacteriol. doi: 10.1128/jb.174.16.5309-5316.1992 – volume: 26 start-page: 1938 year: 2014 ident: 10.1194/jlr.M057919_bib15 article-title: The origin and biosynthesis of the benzenoid moiety of ubiquinone (coenzyme Q) in Arabidopsis. publication-title: Plant Cell. doi: 10.1105/tpc.114.125807 – volume: 9 start-page: 1450 year: 2008 ident: 10.1194/jlr.M057919_bib45 article-title: Identification of bacterial carotenoid cleavage dioxygenase homologues that cleave the interphenyl alpha,beta double bond of stilbene derivatives via a monooxygenase reaction publication-title: ChemBioChem. doi: 10.1002/cbic.200700724 – volume: 584 start-page: 652 year: 2010 ident: 10.1194/jlr.M057919_bib20 article-title: A subunit of decaprenyl diphosphate synthase stabilizes octaprenyl diphosphate synthase in Escherichia coli by forming a high-molecular weight complex publication-title: FEBS Lett. doi: 10.1016/j.febslet.2009.12.029 – volume: 7 start-page: S62 issue: Suppl year: 2007 ident: 10.1194/jlr.M057919_bib12 article-title: Endogenous synthesis of coenzyme Q in eukaryotes publication-title: Mitochondrion. doi: 10.1016/j.mito.2007.03.007 – volume: 123 start-page: 435 year: 1971 ident: 10.1194/jlr.M057919_bib33 article-title: Ubiquinone biosynthesis in Escherichia coli K-12. Accumulation of an octaprenol, farnesylfarnesylgeraniol, by a multiple aromatic auxotroph publication-title: Biochem. J. doi: 10.1042/bj1230435 – volume: 28 start-page: 4457 year: 2014 ident: 10.1194/jlr.M057919_bib44 article-title: Evidence for compartmentalization of mammalian carotenoid metabolism publication-title: FASEB J. doi: 10.1096/fj.14-252411 – volume: 1831 start-page: 776 year: 2013 ident: 10.1194/jlr.M057919_bib13 article-title: A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae publication-title: Biochim. Biophys. Acta. doi: 10.1016/j.bbalip.2012.12.007 – volume: 5 start-page: 493 year: 2006 ident: 10.1194/jlr.M057919_bib37 article-title: Therapeutic potential of resveratrol: the in vivo evidence publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd2060 – volume: 10 start-page: 849 year: 2011 ident: 10.1194/jlr.M057919_bib47 article-title: Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: focus on recent discoveries publication-title: CNS Neurol. Disord. Drug Targets. doi: 10.2174/187152711798072310 – volume: 6 start-page: 515 year: 2010 ident: 10.1194/jlr.M057919_bib34 article-title: 4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.372 – volume: 7 start-page: S41 issue: Suppl year: 2007 ident: 10.1194/jlr.M057919_bib3 article-title: The antioxidant role of coenzyme Q publication-title: Mitochondrion. doi: 10.1016/j.mito.2007.02.006 – volume: 81 start-page: 4819 year: 1984 ident: 10.1194/jlr.M057919_bib25 article-title: Two nuclear mutations that block mitochondrial protein import in yeast publication-title: Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.81.15.4819 – volume: 477 start-page: 482 year: 2011 ident: 10.1194/jlr.M057919_bib39 article-title: Absence of effects of Sir2 overexpression on lifespan in C. elegansDrosophila. publication-title: Nature. doi: 10.1038/nature10296 – volume: 1821 start-page: 78 year: 2012 ident: 10.1194/jlr.M057919_bib43 article-title: Mammalian carotenoid-oxygenases: key players for carotenoid function and homeostasis publication-title: Biochim. Biophys. Acta. doi: 10.1016/j.bbalip.2011.04.010 – volume: 146 start-page: 591 year: 2009 ident: 10.1194/jlr.M057919_bib6 article-title: Disulfide bond formation system in Escherichia coli. publication-title: J. Biochem. doi: 10.1093/jb/mvp102 – volume: 1797 start-page: 1587 year: 2010 ident: 10.1194/jlr.M057919_bib2 article-title: Occurrence, biosynthesis and function of isoprenoid quinones publication-title: Biochim. Biophys. Acta. doi: 10.1016/j.bbabio.2010.06.007 – volume: 171 start-page: 183 year: 1975 ident: 10.1194/jlr.M057919_bib32 article-title: 4-Hydroxybenzoate: polyprenyl transferase and the prenylation of 4-aminobenzoate in mammalian tissues publication-title: Arch. Biochem. Biophys. doi: 10.1016/0003-9861(75)90022-3 – volume: 6 start-page: e19881 year: 2011 ident: 10.1194/jlr.M057919_bib41 article-title: What is new for an old molecule? Systematic review and recommendations on the use of resveratrol publication-title: PLoS ONE. doi: 10.1371/journal.pone.0019881 – volume: 40 start-page: 1 year: 1983 ident: 10.1194/jlr.M057919_bib17 article-title: Biosynthesis of ubiquinone publication-title: Vitam. Horm. doi: 10.1016/S0083-6729(08)60431-8 – volume: 396 start-page: 74 year: 2010 ident: 10.1194/jlr.M057919_bib1 article-title: Coenzyme Q–biosynthesis and functions publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2010.02.147 – volume: 288 start-page: 20085 year: 2013 ident: 10.1194/jlr.M057919_bib31 article-title: ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.480368 – volume: 3 start-page: 410 year: 2011 ident: 10.1194/jlr.M057919_bib28 article-title: Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice publication-title: EMBO Mol. Med. doi: 10.1002/emmm.201100149 |
| SSID | ssj0014461 |
| Score | 2.3247223 |
| Snippet | Coenzyme Q (Q or ubiquinone) is a redox-active polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial... |
| SourceID | doaj pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 909 |
| SubjectTerms | Animals antioxidants Cell Line, Tumor Coumaric Acids - metabolism Escherichia coli - metabolism Humans isoprenoids lipids/chemistry mass spectrometry Mice mitochondria plant polyphenols Propionates Resveratrol Saccharomyces cerevisiae - metabolism stilbene Stilbenes - metabolism ubiquinone Ubiquinone - biosynthesis Ubiquinone - chemistry |
| Title | Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis[S] |
| URI | https://dx.doi.org/10.1194/jlr.M057919 https://www.ncbi.nlm.nih.gov/pubmed/25681964 https://www.proquest.com/docview/1668238138 https://pubmed.ncbi.nlm.nih.gov/PMC4373747 https://doaj.org/article/a01453323fcb4b8795d47a3f5b41b914 |
| Volume | 56 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlPbSX0iZ9bB9BhdBDwYnXkm3puAkNISGFpk0bKEVI8ohu2djB3hS2vz4zfiy7bSCXXm1hyZqR5pvR6BvGdoAMKeLUyIdURDJYGyGOcxEoBdJJ2pbpRPf0Y3Z0Lo8v0ouVUl-UE9bRA3cTt2fp3EuIRATvpKPS2IXMrQipk2On2xLWCdq8wZnqzw_QyRkPPOFJkqf9zTz02Pd-zerdU7qCSeQ6K7aopexfM0n_Qs6_MydXTNHhY_aox5B80o39CbsH5SbbmpToP18u-DveZnW24fJN9uBgqOi2xb6eQfObSJTrasZtWXDi_Y58RVnWCDk5BWiB24ZTrI9f1RSKb6q64Qhsua-g_LO4BP6Ju2nVLEpEjs20-f75x1N2fvjhy8FR1NdViDz6D3OUiHeQKItYTo_BxU4irgsIHRCbCQDtcZnHEnIhhdABPT4LOtVO-xjiXIMSz9hGWZXwgnGZx0WwEBLlhVQuWK9VFhIBuGsWoZAj9n6YYeN70nGqfTEzrfOhpUFxmF4cI7azbHzVcW3c3myfRLVsQgTZ7QNUG9OrjblLbUZsdxC06bFGhyHwU9Pbe307qINBsdGxii2hum7MOMsUAR-hRux5px7LsSXE76Yz7C5fU5y1wa-_Kac_W5Zv4pxCX-_l__jbV-whAr20yzh6zTbm9TW8QTA1d9vs_uTk7NvJdrt-bgDJDh-N |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Resveratrol+and+para-coumarate+serve+as+ring+precursors+for+coenzyme+Q+biosynthesis&rft.jtitle=Journal+of+lipid+research&rft.au=Xie%2C+Letian+X.&rft.au=Williams%2C+Kevin+J.&rft.au=He%2C+Cuiwen+H.&rft.au=Weng%2C+Emily&rft.date=2015-04-01&rft.pub=The+American+Society+for+Biochemistry+and+Molecular+Biology&rft.issn=0022-2275&rft.eissn=1539-7262&rft.volume=56&rft.issue=4&rft.spage=909&rft.epage=919&rft_id=info:doi/10.1194%2Fjlr.M057919&rft_id=info%3Apmid%2F25681964&rft.externalDocID=PMC4373747 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-2275&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-2275&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-2275&client=summon |