Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease

• Published in: Microbiome Vol. 5; no. 1; pp. 55 - 8
• Main Authors: Khanna, Sahil, Vazquez-Baeza, Yoshiki, González, Antonio, Weiss, Sophie, Schmidt, Bradley, Muñiz-Pedrogo, David A., Rainey, John F., Kammer, Patricia, Nelson, Heidi, Sadowsky, Michael, Khoruts, Alexander, Farrugia, Stefan L., Knight, Rob, Pardi, Darrell S., Kashyap, Purna C.
• Format: Journal Article
• Language: English
• Published: England BioMed Central 15.05.2017; BMC
• Subjects: Adult; Aged; Aged, 80 and over; Bacteria - classification; Bacteria - genetics; Bioinformatics; Clostridioides difficile - physiology; Clostridium difficile infection; Clostridium Infections - complications; Clostridium Infections - microbiology; Clostridium Infections - therapy; Colonization; Ecology; Fecal microbiota transplantation; Fecal Microbiota Transplantation - methods; Fecal microflora; Feces; Feces - microbiology; Female; Gastrointestinal Microbiome; Homeostasis; Humans; Infections; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - microbiology; Inflammatory diseases; Intestinal microflora; Intestine; Male; Microbiome; Middle Aged; New taxa; Pathogens; Patients; Phylogenetics; Recurrent infection; Sequence Analysis, DNA; Success; Transplantation; Transplants & implants; Young Adult; Inflammatory bowel disease; Clostridium difficile infection; Fecal microbiota transplantation; Microbiome

Gut microbiota play a key role in maintaining homeostasis in the human gut. Alterations in the gut microbial ecosystem predispose to Clostridium difficile infection (CDI) and gut inflammatory disorders such as inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) from a healthy do...