Synthetic Strategies for Peroxide Ring Construction in Artemisinin

• Published in: Molecules (Basel, Switzerland) Vol. 22; no. 1; p. 117
• Main Authors: Vil’, Vera, Yaremenko, Ivan, Ilovaisky, Alexey, Terent’ev, Alexander
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.01.2017; MDPI
• Subjects: Acids; Antimalarials - chemical synthesis; Antimalarials - history; artemisinic acid; artemisinin; Artemisinins - chemical synthesis; Artemisinins - chemistry; Artemisinins - history; Chemistry Techniques, Synthetic - history; Chemistry Techniques, Synthetic - methods; Construction; cycles; History, 20th Century; History, 21st Century; Humans; Infections; Interdisciplinary aspects; Malaria; Manufacturing; Metabolites; organic peroxide; Oxidation-Reduction; Ozone - chemistry; peroxidation; Peroxides - chemistry; Pharmaceuticals; Review; Singlet Oxygen - chemistry; Stereoisomerism; artemisinin; artemisinic acid; cycles; organic peroxide; peroxidation

The present review summarizes publications on the artemisinin peroxide fragment synthesis from 1983 to 2016. The data are classified according to the structures of a precursor used in the key peroxidation step of artemisinin peroxide cycle synthesis. The first part of the review comprises the constr...