Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

• Published in: Journal of lipid research Vol. 60; no. 10; pp. 1648 - 1697
• Main Authors: Funcke, Jan-Bernd, Scherer, Philipp E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Adiponectin - metabolism; Adipose Tissue - metabolism; Adipose Tissue - pathology; angiopoietin; angiopoietin-like protein; Animals; bone morphogenic protein; chemerin; endotrophin; extracellular vesicles; fatty acid esters of hydroxy fatty acids; fibroblast growth factor 21; Humans; Leptin - metabolism; Lipid Metabolism; lipocalin 2; long noncoding ribonucleic acids; lysophosphatidic acids; micro-ribonucleic acids; neuregulin 4; Signal Transduction; sphingolipids; Thematic Review Series; uric acid; uridine; fibroblast growth factor 21; extracellular vesicles; sphingolipids; endotrophin; lipocalin 2; angiopoietin; angiopoietin-like protein; uridine; long noncoding ribonucleic acids; fatty acid esters of hydroxy fatty acids; lysophosphatidic acids; chemerin; neuregulin 4; bone morphogenic protein; uric acid; micro-ribonucleic acids

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue-secreted signaling mediators (adipokines) have been identified since then, and much has been learned about how adipose ti...