HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer’s Disease Brain

• Published in: Molecular neurobiology Vol. 54; no. 1; pp. 188 - 199
• Main Authors: García-Ayllón, María-Salud, Botella-López, Arancha, Cuchillo-Ibañez, Inmaculada, Rábano, Alberto, Andreasen, Niels, Blennow, Kaj, Ávila, Jesús, Sáez-Valero, Javier
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2017; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amino Acid Sequence; Animals; Biomedical and Life Sciences; Biomedicine; Brain; Brain - metabolism; Brain - pathology; Carrier Proteins - genetics; Carrier Proteins - metabolism; CD57 Antigens - genetics; CD57 Antigens - metabolism; Cell Biology; Cell Line, Tumor; Enzymes; Female; Glycoproteins - genetics; Glycoproteins - metabolism; Humans; Longitudinal Studies; Male; Medicin och hälsovetenskap; Mice; Mice, Transgenic; Neurobiology; Neurology; Neurosciences; Neurovetenskaper; Proteins; HNK-1; Glycoform; Cerebrospinal fluid; Alzheimer’s disease; Glycoprotein; β-amyloid

The human natural killer-1 (HNK-1), 3-sulfonated glucuronic acid, is a glycoepitope marker of cell adhesion that participates in cell-cell and cell-extracellular matrix interactions and in neurite growth. Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, par...