Significant Roles of Notch O-Glycosylation in Cancer

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 6; p. 1783
• Main Authors: Wang, Weiwei, Okajima, Tetsuya, Takeuchi, Hideyuki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.03.2022; MDPI
• Subjects: Amino acids; Animals; Blood cancer; cancer; EGF repeat; Epidermal growth factor; Fucose - chemistry; Glycosylation; Homeostasis; Insects; Ligands; Liver cancer; Mutation; N-Acetylglucosaminyltransferases - metabolism; Neoplasms; notch signaling; O-glycosylation; Proteins; Receptors, Notch - metabolism; Regulation; Review; O-glycosylation; cancer; EGF repeat; notch signaling

Notch signaling, which was initially identified in Drosophila wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling leads to various human diseases, including many types...