Differences in Cytokine Expression and STAT3 Activation between Healthy Controls and Patients of Unexplained Recurrent Spontaneous Abortion (URSA) during Early Pregnancy

• Published in: PloS one Vol. 11; no. 9; p. e0163252
• Main Authors: Cai, JunYing, Li, MuJun, Huang, QianYi, Fu, XiaoQian, Wu, HuiMei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2016; Public Library of Science (PLoS)
• Subjects: Activation; Antigens; Biology and Life Sciences; Blood; Cytokines; Decidua; Enzyme-linked immunosorbent assay; Hospitals; Immune system; Immunological tolerance; Immunology; Inflammation; Interleukin; Interleukin 10; Interleukin 17; Interleukin 23; Interleukin 6; Lymphocytes; Medicine and Health Sciences; Miscarriage; Pathogenesis; Patients; Peripheral blood; Phosphorylation; Pregnancy; Research and Analysis Methods; Stat3 protein; Transcription; Transcription factors; Transducers; Womens health; China

Unexplained recurrent spontaneous abortion (URSA) is a common complication of pregnancy. Although tolerance of the maternal immune system is considered to be essential for a normal pregnancy, the precise mechanism underlying the pathogenesis of URSA remains to be fully elucidated, albeit it is known...