Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 3; p. 675
• Main Authors: Pan, Pan, Zhang, Hongmin, Su, Longxiang, Wang, Xiaoting, Liu, Dawei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.03.2018; MDPI
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Cardiomyocytes; Cardiomyopathy; Cell Line; Gene Expression Regulation - drug effects; heart; Lipopolysaccharides - adverse effects; LPS; Melatonin; Melatonin - pharmacology; Membrane Potential, Mitochondrial - drug effects; Mice; Mice, Knockout; Mitochondria, Heart - drug effects; Mitochondrial DNA; Myocytes, Cardiac - cytology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Permeability; Proteins; Reactive Oxygen Species - metabolism; Rodents; UCP2; Uncoupling Protein 2 - genetics; Uncoupling Protein 2 - metabolism; apoptosis; autophagy; melatonin; LPS; heart; UCP2

To explore the mechanism of mitochondrial uncoupling protein 2 (UCP2) mediating the protective of melatonin when septic cardiomyopathy. UCP2 knocked out mice and cardiomyocytes were used to study the effect of melatonin in response to LPS. Indicators of myocardial and mitochondria injury including m...