Antineoplastic treatment effect on bone mineral density in Mexican breast cancer patients
Breast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in those who receive it. The aim of this study was to assess the impact of cancer treatment on bone mineral density (BMD) and bone mineral content (BMC), in...
Saved in:
Published in | BMC cancer Vol. 16; no. 1; p. 860 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
BioMed Central Ltd
08.11.2016
BioMed Central |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Breast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in those who receive it. The aim of this study was to assess the impact of cancer treatment on bone mineral density (BMD) and bone mineral content (BMC), in patients with breast cancer and explore the interaction of menopausal status and clinical stage with cancer treatment on such changes.
A quasi-experimental design was applied with measurements before and after a chemotherapy treatment in 40 patients with primary diagnosis of invasive breast cancer. BMD and body composition measurements were taken by dual X-ray absorptiometry (DXA) and changes in these variables due to therapy were analyzed using mixed regression for repeated measurements.
Significant loss was found in femoral neck and L2-L4 BMD (p < 0.001). Patients diagnosed with osteopenia or osteoporosis received calcium + vitamin D supplementation (600 mg/200 IU day). It showed a protective effect in the decrease of femoral neck BMD and total BMC. BMD loss in both femoral neck and L2-L4 BMD was higher in premenopausal women: 0.023 g/cm
in femoral neck and 0.063 g/cm
in L2-L4 (p < 0.001), while in postmenopausal women BMD loss was 0.015 g/cm
in femoral neck and 0.035 g/cm
in L2-L4 (p = 0.021 and p = 0.001 respectively). Change in lumbar spine BMD was prominent in premenopausal women with advanced clinical stage (IIB, IIIA, IIIB): 0.066 g/cm
(p = 0.003).
The antineoplastic breast cancer treatment with chemotherapy had a negative impact on BMD, in premenopausal women overall, although a differential effect was found according to clinical stage and calcium supplementation status. |
---|---|
AbstractList | Breast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in those who receive it. The aim of this study was to assess the impact of cancer treatment on bone mineral density (BMD) and bone mineral content (BMC), in patients with breast cancer and explore the interaction of menopausal status and clinical stage with cancer treatment on such changes.
A quasi-experimental design was applied with measurements before and after a chemotherapy treatment in 40 patients with primary diagnosis of invasive breast cancer. BMD and body composition measurements were taken by dual X-ray absorptiometry (DXA) and changes in these variables due to therapy were analyzed using mixed regression for repeated measurements.
Significant loss was found in femoral neck and L2-L4 BMD (p < 0.001). Patients diagnosed with osteopenia or osteoporosis received calcium + vitamin D supplementation (600 mg/200 IU day). It showed a protective effect in the decrease of femoral neck BMD and total BMC. BMD loss in both femoral neck and L2-L4 BMD was higher in premenopausal women: 0.023 g/cm
in femoral neck and 0.063 g/cm
in L2-L4 (p < 0.001), while in postmenopausal women BMD loss was 0.015 g/cm
in femoral neck and 0.035 g/cm
in L2-L4 (p = 0.021 and p = 0.001 respectively). Change in lumbar spine BMD was prominent in premenopausal women with advanced clinical stage (IIB, IIIA, IIIB): 0.066 g/cm
(p = 0.003).
The antineoplastic breast cancer treatment with chemotherapy had a negative impact on BMD, in premenopausal women overall, although a differential effect was found according to clinical stage and calcium supplementation status. BACKGROUNDBreast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in those who receive it. The aim of this study was to assess the impact of cancer treatment on bone mineral density (BMD) and bone mineral content (BMC), in patients with breast cancer and explore the interaction of menopausal status and clinical stage with cancer treatment on such changes.METHODSA quasi-experimental design was applied with measurements before and after a chemotherapy treatment in 40 patients with primary diagnosis of invasive breast cancer. BMD and body composition measurements were taken by dual X-ray absorptiometry (DXA) and changes in these variables due to therapy were analyzed using mixed regression for repeated measurements.RESULTSSignificant loss was found in femoral neck and L2-L4 BMD (p < 0.001). Patients diagnosed with osteopenia or osteoporosis received calcium + vitamin D supplementation (600 mg/200 IU day). It showed a protective effect in the decrease of femoral neck BMD and total BMC. BMD loss in both femoral neck and L2-L4 BMD was higher in premenopausal women: 0.023 g/cm2 in femoral neck and 0.063 g/cm2 in L2-L4 (p < 0.001), while in postmenopausal women BMD loss was 0.015 g/cm2 in femoral neck and 0.035 g/cm2 in L2-L4 (p = 0.021 and p = 0.001 respectively). Change in lumbar spine BMD was prominent in premenopausal women with advanced clinical stage (IIB, IIIA, IIIB): 0.066 g/cm2 (p = 0.003).CONCLUSIONThe antineoplastic breast cancer treatment with chemotherapy had a negative impact on BMD, in premenopausal women overall, although a differential effect was found according to clinical stage and calcium supplementation status. Background Breast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in those who receive it. The aim of this study was to assess the impact of cancer treatment on bone mineral density (BMD) and bone mineral content (BMC), in patients with breast cancer and explore the interaction of menopausal status and clinical stage with cancer treatment on such changes. Methods A quasi-experimental design was applied with measurements before and after a chemotherapy treatment in 40 patients with primary diagnosis of invasive breast cancer. BMD and body composition measurements were taken by dual X-ray absorptiometry (DXA) and changes in these variables due to therapy were analyzed using mixed regression for repeated measurements. Results Significant loss was found in femoral neck and L2-L4 BMD (p < 0.001). Patients diagnosed with osteopenia or osteoporosis received calcium + vitamin D supplementation (600 mg/200 IU day). It showed a protective effect in the decrease of femoral neck BMD and total BMC. BMD loss in both femoral neck and L2-L4 BMD was higher in premenopausal women: 0.023 g/cm2 in femoral neck and 0.063 g/cm2 in L2-L4 (p < 0.001), while in postmenopausal women BMD loss was 0.015 g/cm2 in femoral neck and 0.035 g/cm2 in L2-L4 (p = 0.021 and p = 0.001 respectively). Change in lumbar spine BMD was prominent in premenopausal women with advanced clinical stage (IIB, IIIA, IIIB): 0.066 g/cm2 (p = 0.003). Conclusion The antineoplastic breast cancer treatment with chemotherapy had a negative impact on BMD, in premenopausal women overall, although a differential effect was found according to clinical stage and calcium supplementation status. |
ArticleNumber | 860 |
Audience | Academic |
Author | Guevara-Torres, Alfonso G Monroy-Cisneros, Karina Valencia, Mauro E Esparza-Romero, Julián Astiazarán-García, Humberto Méndez-Estrada, Rosa O Anduro-Corona, Iván |
Author_xml | – sequence: 1 givenname: Karina surname: Monroy-Cisneros fullname: Monroy-Cisneros, Karina organization: Centro de Investigación en Alimentación y Desarrollo (CIAD), Coordinación de Nutrición, Carretera a La Victoria km 0.6, C.P. 83304, Hermosillo, Sonora, Mexico – sequence: 2 givenname: Julián surname: Esparza-Romero fullname: Esparza-Romero, Julián organization: Centro de Investigación en Alimentación y Desarrollo (CIAD), Coordinación de Nutrición, Carretera a La Victoria km 0.6, C.P. 83304, Hermosillo, Sonora, Mexico – sequence: 3 givenname: Mauro E surname: Valencia fullname: Valencia, Mauro E organization: Departamento de Ciencias Químico-Biológicas, Coordinación de Ciencias Nutricionales, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Hermosillo, Sonora, Mexico – sequence: 4 givenname: Alfonso G surname: Guevara-Torres fullname: Guevara-Torres, Alfonso G organization: Centro Estatal de Oncología (CEO), Reforma final y Paseo Río San Miguel, C.P. 83280, Hermosillo, Sonora, Mexico – sequence: 5 givenname: Rosa O surname: Méndez-Estrada fullname: Méndez-Estrada, Rosa O organization: Centro de Investigación en Alimentación y Desarrollo (CIAD), Coordinación de Nutrición, Carretera a La Victoria km 0.6, C.P. 83304, Hermosillo, Sonora, Mexico – sequence: 6 givenname: Iván surname: Anduro-Corona fullname: Anduro-Corona, Iván organization: Centro de Investigación en Alimentación y Desarrollo (CIAD), Coordinación de Nutrición, Carretera a La Victoria km 0.6, C.P. 83304, Hermosillo, Sonora, Mexico – sequence: 7 givenname: Humberto surname: Astiazarán-García fullname: Astiazarán-García, Humberto email: hastiazaran@ciad.mx organization: Centro de Investigación en Alimentación y Desarrollo (CIAD), Coordinación de Nutrición, Carretera a La Victoria km 0.6, C.P. 83304, Hermosillo, Sonora, Mexico. hastiazaran@ciad.mx |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27821086$$D View this record in MEDLINE/PubMed |
BookMark | eNptkl1rFDEUhoNUbLv6A7yRgCB6MTXJTGYyN8JS_ChUBD8uvArZzMluykyynWRk--89y9a6I5KLhJznPV-85-QkxACEPOfsgnNVv01cKCULxutCtEwWu0fkjFcNL0TFmpOj9yk5T-mGMd4opp6QU9EowZmqz8jPZcg-QNz2JmVvaR7B5AFCpuAc2ExjoCusSgekRtPTDkLy-Y76QD_DzluDcdSkTPFpYaRbkz3q01Py2Jk-wbP7e0F-fHj__fJTcf3l49Xl8rqwUra54FYK5kRrKmCd6xSrS5ytNY1xsi27mrvOWeZcWXEJYiVq0YFsGMiqMi1IKBfk3SHvdloN0FmsjX3q7egHM97paLyeR4Lf6HX8pSVnTEiFCV7fJxjj7QQp68EnC31vcC9T0lyVjVBVie0syMt_0Js4jQHHQ6qSJReMV3-ptelB--Ai1rX7pHpZNUwq7F0gdfEfCk8Hg7e4cufxfyZ4MxMgk2GX12ZKSV99-zpnXx2xGzB93qTYT9nHkOYgP4B2jCmN4B4Wx5nem0wfTKbRZHpvMr1DzYvjjT8o_riq_A1zE81B |
CitedBy_id | crossref_primary_10_1002_jbm4_10519 crossref_primary_10_3389_fphys_2016_00679 crossref_primary_10_3390_biology11040524 crossref_primary_10_1016_j_clnu_2020_02_017 crossref_primary_10_1186_s12885_022_10203_4 crossref_primary_10_1007_s00520_021_06231_8 crossref_primary_10_1186_s13619_022_00108_9 crossref_primary_10_3945_an_116_014423 crossref_primary_10_3892_mmr_2018_9764 crossref_primary_10_1016_j_clnu_2021_01_006 crossref_primary_10_1016_j_medengphy_2023_103982 |
Cites_doi | 10.1200/JCO.1997.15.3.955 10.1007/978-1-4757-3656-4 10.1200/JCO.1997.15.4.1341 10.1016/S1470-2045(13)70048-2 10.1007/s10549-011-1705-x 10.1007/s10549-006-9292-y 10.1210/me.2009-0354 10.1200/JCO.2010.32.5209 10.1200/JCO.2009.24.5902 10.1007/978-1-4419-5515-9 10.1200/JCO.2007.15.4997 10.6004/jnccn.2013.0098 10.1016/S1470-2045(08)70153-0 10.1200/JCO.2009.26.3756 10.1593/neo.10282 10.1200/JCO.2001.19.14.3306 10.1359/jbmr.060508 10.1002/jbmr.5650110802 10.1200/JCO.2002.11.080 10.1590/S0036-36342009000800017 10.1016/S1470-2045(08)70160-8 10.1056/NEJM199502023320506 10.1016/j.bone.2006.06.027 10.1002/ijc.29210 10.1093/aje/kwh313 10.1200/JCO.2003.08.017 10.1016/S1470-2045(07)70003-7 10.1152/physrev.00016.2008 10.1016/j.bone.2007.06.004 10.1200/JCO.2001.19.9.2381 10.1385/JCD:4:4:373 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2016 BioMed Central Ltd. Copyright BioMed Central 2016 The Author(s). 2016 |
Copyright_xml | – notice: COPYRIGHT 2016 BioMed Central Ltd. – notice: Copyright BioMed Central 2016 – notice: The Author(s). 2016 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION ISR 3V. 7TO 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH H94 K9. M0S M1P PIMPY PQEST PQQKQ PQUKI PRINS 7X8 5PM |
DOI | 10.1186/s12885-016-2905-x |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Gale In Context: Science ProQuest Central (Corporate) Oncogenes and Growth Factors Abstracts Health & Medical Complete (ProQuest Database) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials AUTh Library subscriptions: ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database Oncogenes and Growth Factors Abstracts ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest Medical Library ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea AIDS and Cancer Research Abstracts ProQuest One Academic ProQuest Medical Library (Alumni) ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1471-2407 |
EndPage | 860 |
ExternalDocumentID | 4267996181 A470585442 10_1186_s12885_016_2905_x 27821086 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: ; |
GroupedDBID | --- -A0 0R~ 23N 2WC 3V. 4.4 53G 5VS 6J9 6PF 7X7 88E 8FI 8FJ AAFWJ AAJSJ AAWTL ABDBF ABUWG ACGFO ACGFS ACIHN ACMJI ACPRK ACRMQ ADBBV ADINQ ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AHBYD AHMBA AHSBF AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C24 C6C CCPQU CGR CS3 CUY CVF DIK DU5 E3Z EAD EAP EAS EBD EBLON EBS ECM EIF EJD EMB EMK EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HMCUK HYE IAO IHR IHW INH INR ISR ITC KQ8 M1P M48 M~E NPM O5R O5S OK1 P2P PGMZT PIMPY PQQKQ PROAC PSQYO RBZ RNS ROL RPM RSV SBL SOJ SV3 TR2 TUS U2A UKHRP W2D WOQ WOW XSB AAYXX CITATION AFGXO 7TO 7XB 8FK AZQEC DWQXO H94 K9. PQEST PQUKI PRINS 7X8 5PM |
ID | FETCH-LOGICAL-c559t-1c520f29a4e0dfd80631189a7af593d61fdfc0ff3415e2b262de570e544a9e5e3 |
IEDL.DBID | RPM |
ISSN | 1471-2407 |
IngestDate | Tue Sep 17 21:28:01 EDT 2024 Fri Aug 16 01:10:08 EDT 2024 Thu Oct 10 20:44:46 EDT 2024 Wed Aug 14 18:53:42 EDT 2024 Tue Aug 13 05:21:52 EDT 2024 Sat Sep 28 21:18:17 EDT 2024 Tue Aug 13 02:41:16 EDT 2024 Thu Sep 12 17:47:40 EDT 2024 Sat Sep 28 08:00:13 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | Bone resorption Chemotherapy Calcium Menopause Breast neoplasm |
Language | English |
License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c559t-1c520f29a4e0dfd80631189a7af593d61fdfc0ff3415e2b262de570e544a9e5e3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100258/ |
PMID | 27821086 |
PQID | 1845312014 |
PQPubID | 44074 |
PageCount | 1 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5100258 proquest_miscellaneous_1837284359 proquest_journals_1845312014 gale_infotracmisc_A470585442 gale_infotracacademiconefile_A470585442 gale_incontextgauss_ISR_A470585442 gale_healthsolutions_A470585442 crossref_primary_10_1186_s12885_016_2905_x pubmed_primary_27821086 |
PublicationCentury | 2000 |
PublicationDate | 2016-11-08 |
PublicationDateYYYYMMDD | 2016-11-08 |
PublicationDate_xml | – month: 11 year: 2016 text: 2016-11-08 day: 08 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: London |
PublicationTitle | BMC cancer |
PublicationTitleAlternate | BMC Cancer |
PublicationYear | 2016 |
Publisher | BioMed Central Ltd BioMed Central |
Publisher_xml | – name: BioMed Central Ltd – name: BioMed Central |
References | 16768029 - Nutr Hosp. 2006 May;21 Suppl 3:38-45 9193325 - J Clin Oncol. 1997 Apr;15(4):1341-7 20053716 - Mol Endocrinol. 2010 Feb;24(2):323-34 21822637 - Breast Cancer Res Treat. 2012 Jan;131(1):169-76 9060533 - J Clin Oncol. 1997 Mar;15(3):955-62 12149294 - J Clin Oncol. 2002 Aug 1;20(15):3219-24 15561988 - Am J Epidemiol. 2004 Dec 1;160(11):1087-97 18598925 - Lancet Oncol. 2008 Jul;9(7):605-7 11331316 - J Clin Oncol. 2001 May 1;19(9):2381-9 16869719 - J Bone Miner Res. 2006 Aug;21(8):1215-23 25220842 - Int J Cancer. 2015 Mar 1;136(5):E359-86 25335676 - Nutr Hosp. 2014 Oct 01;30(4):876-82 19967282 - Salud Publica Mex. 2009;51 Suppl 2:s263-9 16904960 - Bone. 2007 Jan;40(1):205-10 11748342 - J Clin Densitom. 2001 Winter;4(4):373-80 18539529 - Lancet Oncol. 2008 Jul;9(7):629-35 18779616 - J Clin Oncol. 2008 Sep 10;26(26):4289-95 23847214 - J Natl Compr Canc Netw. 2013 Jul;11(7):753-60; quiz 761 17618847 - Bone. 2007 Sep;41(3):346-52 17080310 - Breast Cancer Res Treat. 2007 Mar;102(1):85-101 11454877 - J Clin Oncol. 2001 Jul 15;19(14):3306-11 21343561 - J Clin Oncol. 2011 Mar 20;29(9):1221-7 20651986 - Neoplasia. 2010 Jul;12(7):571-8 20625130 - J Clin Oncol. 2010 Aug 10;28(23):3784-96 12963702 - J Clin Oncol. 2003 Nov 1;21(21):4042-57 8854239 - J Bone Miner Res. 1996 Aug;11(8):1043-51 19342610 - Physiol Rev. 2009 Apr;89(2):381-410 7816067 - N Engl J Med. 1995 Feb 2;332(5):305-11 23628188 - Lancet Oncol. 2013 Apr;14(5):391-436 20065185 - J Clin Oncol. 2010 Feb 20;28(6):967-75 17267326 - Lancet Oncol. 2007 Feb;8(2):119-27 MF Abdel-Maksoud (2905_CR6) 2012; 131 JM Argilés (2905_CR29) 2006; 21 RL Theriault (2905_CR15) 2013; 11 C Confavreux (2905_CR22) 2007; 41 RE Coleman (2905_CR23) 2007; 8 CH Poznak Van (2905_CR34) 2011; 29 2905_CR8 PE Goss (2905_CR2) 2013; 14 R Roubenoff (2905_CR18) 2008; 9 J Ferlay (2905_CR1) 2015; 136 R Eastell (2905_CR24) 2006; 21 T Powles (2905_CR13) 2002; 20 2905_CR35 CL Shapiro (2905_CR9) 2001; 19 CM Prado (2905_CR17) 2008; 9 T Saarto (2905_CR31) 2008; 26 S Gonnelli (2905_CR25) 2007; 40 C Poznak Van (2905_CR10) 2010; 28 ML Slattery (2905_CR7) 2007; 102 NA Berger (2905_CR27) 2010 PG Fournier (2905_CR33) 2010; 12 W Demark-Wahnefried (2905_CR30) 2001; 19 M Martin-Millan (2905_CR21) 2010; 24 R Pacifici (2905_CR4) 1996; 11 SC Manolagas (2905_CR19) 1995; 332 T Saarto (2905_CR12) 1997; 15 A Mohar (2905_CR3) 2009; 51 SL Greenspan (2905_CR5) 2002; 4 P Delmas (2905_CR11) 1997; 15 BE Hillner (2905_CR32) 2003; 21 K Baumgartner (2905_CR16) 2004; 160 2905_CR20 K Monroy Cisneros (2905_CR26) 2014; 30 HJ Burstein (2905_CR14) 2010; 28 2905_CR28 |
References_xml | – volume: 21 start-page: 38 year: 2006 ident: 2905_CR29 publication-title: Nutr Hosp contributor: fullname: JM Argilés – volume: 15 start-page: 955 issue: 3 year: 1997 ident: 2905_CR11 publication-title: J Clin Oncol doi: 10.1200/JCO.1997.15.3.955 contributor: fullname: P Delmas – ident: 2905_CR8 doi: 10.1007/978-1-4757-3656-4 – volume: 15 start-page: 1341 issue: 4 year: 1997 ident: 2905_CR12 publication-title: J Clin Oncol doi: 10.1200/JCO.1997.15.4.1341 contributor: fullname: T Saarto – volume: 14 start-page: 391 issue: 5 year: 2013 ident: 2905_CR2 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(13)70048-2 contributor: fullname: PE Goss – volume: 131 start-page: 169 issue: 1 year: 2012 ident: 2905_CR6 publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-011-1705-x contributor: fullname: MF Abdel-Maksoud – volume: 102 start-page: 85 issue: 1 year: 2007 ident: 2905_CR7 publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-006-9292-y contributor: fullname: ML Slattery – volume: 24 start-page: 323 issue: 2 year: 2010 ident: 2905_CR21 publication-title: Mol Endocrinol doi: 10.1210/me.2009-0354 contributor: fullname: M Martin-Millan – volume: 29 start-page: 1221 issue: 9 year: 2011 ident: 2905_CR34 publication-title: J Clin Oncol doi: 10.1200/JCO.2010.32.5209 contributor: fullname: CH Poznak Van – volume: 28 start-page: 967 issue: 6 year: 2010 ident: 2905_CR10 publication-title: J Clin Oncol doi: 10.1200/JCO.2009.24.5902 contributor: fullname: C Poznak Van – volume: 30 start-page: 876 issue: 4 year: 2014 ident: 2905_CR26 publication-title: Nutr Hosp contributor: fullname: K Monroy Cisneros – volume-title: Cancer and energy balance, epidemiology and overview year: 2010 ident: 2905_CR27 doi: 10.1007/978-1-4419-5515-9 contributor: fullname: NA Berger – volume: 26 start-page: 4289 issue: 26 year: 2008 ident: 2905_CR31 publication-title: J Clin Oncol doi: 10.1200/JCO.2007.15.4997 contributor: fullname: T Saarto – volume: 11 start-page: 753 issue: 7 year: 2013 ident: 2905_CR15 publication-title: J Natl Compr Cancer Netw doi: 10.6004/jnccn.2013.0098 contributor: fullname: RL Theriault – volume: 9 start-page: 629 issue: 7 year: 2008 ident: 2905_CR17 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(08)70153-0 contributor: fullname: CM Prado – volume: 28 start-page: 3784 issue: 23 year: 2010 ident: 2905_CR14 publication-title: J Clin Oncol doi: 10.1200/JCO.2009.26.3756 contributor: fullname: HJ Burstein – volume: 12 start-page: 571 issue: 7 year: 2010 ident: 2905_CR33 publication-title: Neoplasia doi: 10.1593/neo.10282 contributor: fullname: PG Fournier – volume: 19 start-page: 3306 issue: 14 year: 2001 ident: 2905_CR9 publication-title: J Clin Oncol doi: 10.1200/JCO.2001.19.14.3306 contributor: fullname: CL Shapiro – volume: 21 start-page: 1215 issue: 8 year: 2006 ident: 2905_CR24 publication-title: J Bone Miner Res doi: 10.1359/jbmr.060508 contributor: fullname: R Eastell – volume: 11 start-page: 1043 issue: 8 year: 1996 ident: 2905_CR4 publication-title: J Bone Miner Res doi: 10.1002/jbmr.5650110802 contributor: fullname: R Pacifici – ident: 2905_CR20 – volume: 20 start-page: 3219 issue: 15 year: 2002 ident: 2905_CR13 publication-title: J Clin Oncol doi: 10.1200/JCO.2002.11.080 contributor: fullname: T Powles – volume: 51 start-page: s263 year: 2009 ident: 2905_CR3 publication-title: Salud Publica Mex doi: 10.1590/S0036-36342009000800017 contributor: fullname: A Mohar – volume: 9 start-page: 605 issue: 7 year: 2008 ident: 2905_CR18 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(08)70160-8 contributor: fullname: R Roubenoff – volume: 332 start-page: 305 issue: 5 year: 1995 ident: 2905_CR19 publication-title: N Engl J Med doi: 10.1056/NEJM199502023320506 contributor: fullname: SC Manolagas – ident: 2905_CR35 – volume: 40 start-page: 205 issue: 1 year: 2007 ident: 2905_CR25 publication-title: Bone doi: 10.1016/j.bone.2006.06.027 contributor: fullname: S Gonnelli – volume: 136 start-page: E359 issue: 5 year: 2015 ident: 2905_CR1 publication-title: Int J Cancer doi: 10.1002/ijc.29210 contributor: fullname: J Ferlay – volume: 160 start-page: 1087 issue: 11 year: 2004 ident: 2905_CR16 publication-title: Am J Epidemiol doi: 10.1093/aje/kwh313 contributor: fullname: K Baumgartner – volume: 21 start-page: 4042 issue: 21 year: 2003 ident: 2905_CR32 publication-title: J Clin Oncol doi: 10.1200/JCO.2003.08.017 contributor: fullname: BE Hillner – volume: 8 start-page: 119 issue: 2 year: 2007 ident: 2905_CR23 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(07)70003-7 contributor: fullname: RE Coleman – ident: 2905_CR28 doi: 10.1152/physrev.00016.2008 – volume: 41 start-page: 346 issue: 3 year: 2007 ident: 2905_CR22 publication-title: Bone doi: 10.1016/j.bone.2007.06.004 contributor: fullname: C Confavreux – volume: 19 start-page: 2381 issue: 9 year: 2001 ident: 2905_CR30 publication-title: J Clin Oncol doi: 10.1200/JCO.2001.19.9.2381 contributor: fullname: W Demark-Wahnefried – volume: 4 start-page: 373 issue: 4 year: 2002 ident: 2905_CR5 publication-title: J Clin Densitom doi: 10.1385/JCD:4:4:373 contributor: fullname: SL Greenspan |
SSID | ssj0017808 |
Score | 2.2922034 |
Snippet | Breast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in those who... Background Breast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in... BACKGROUNDBreast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in... |
SourceID | pubmedcentral proquest gale crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 860 |
SubjectTerms | Adult Alfacalcidol Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor Bone Density Bone Diseases - etiology Bone Diseases - pathology Bone resorption Breast cancer Breast Neoplasms - complications Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Calcifediol Cancer Care and treatment Chemotherapy Diagnosis Dosage and administration Female Health aspects Humans Menopause Mexico Middle Aged Neoplasm Staging Postmenopausal women Risk Factors Vitamin D |
SummonAdditionalLinks | – databaseName: Health & Medical Complete (ProQuest Database) dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3di9QwEA96gvgiftvz1CiCIJRr03w-ySIep7A-qAfrU0iT9NwHu3fXLqz_vTNttl598DnTkGYmM5nkl98Q8sbo4HxleB4kkmqbUObaySYPIkhlYq3C8G5t-UWenvHPK7FKB25dglXufeLgqMPG4xn5MWQiYC4Qrvj7i8scq0bh7WoqoXGT3IImjXauVlPCVSpd6HSTWWp53IEv1ghVkzkzhch3s1j0r0e-FpLmcMlr8efkHrmbNo50MWr6PrkR2wfk9jJdjT8kPxZY8wHx4A6pl-mEIKcjZINuWlpv2kh_rQeiaRoQut7_puuWLuMOvSGtEaHeU4-WcEUT5Wr3iJydfPz-4TRPdRNyD_lBn5desKJhxvFYhCZo2IXA_xunXCNMFWTZhMYXTQMBTERWM8lCFKqIgnNnoojVY3LQwoCeEop8YIw5ATo0vPDMGY_884WBHiL40Yy828-gvRjpMeyQVmhpx-m2CCHD6ba7jLzEObbjC89padkFVwVkLZxDd68HCSSmaBH5cu62XWc_ffs6E3qbhJoN6MO79JAARoxcVjPJo5kkrBw_b94r26aV29m_dpaRV1MzfoloNFDjFmUqBWG9EiYjT0bbmP6ewZYLq1dlRM2sZhJAPu95S7v-OfB6C6TDFfrw_8N6Ru4wNOHhaPuIHPRX2_gcNkZ9_WKw_j_Xeg0C priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals (Open Access) dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bi9QwFA7LCuKLeLe6ahRBEKqdNJfmQWQQl1UYH9SB9SmkuawD2tFpB2b_veeknbqVffA5p6E9Obc0X75DyHNdeetKzXMvkVRb-1leWRlzL7xUOtTKp3tri0_yZMk_norTA7JvbzUosL10a4f9pJabH692v8_fgsO_SQ5fydctxNgKIWgyZ7oQOZSUVxgvORr8gv89VFBValA3g3iMhwpqOOS8dIpJmvo3WF_IVlMk5YXUdHyDXB9qSjrvjeAmOQjNLXJ1MZya3ybf5tgOAqHiFlmZ6Qgupz2ag64bWq-bQH-uEgc19Yhq787pqqGLsMNASWsEr3fUoZFs6MDG2t4hy-P3X9-d5ENLhdzB1qHLZ06wIjJteSh89BUUKPD92iobhS69nEUfXREj5DYRWM0k80GoIgjOrQ4ilHfJYQMvdJ9QpApjzApYXs0Lx6x2SE1faJghQIjNyMu9Bs2vnjnDpB1HJU2vboPoMlS32WXkCerY9Jc_R68zc64K2NBwDtM9SxLIWdEgKObMbtvWfPjyeSL0YhCKa1gPZ4c7BvDGSHM1kTyaSIJTuenwfrHN3iYNbIYhYkHFxDPydBzGJxGoBsu4RZlSQcYvhc7Ivd42xq9nUI1hY6uMqInVjAJI9T0daVbfE-W3QKZcUT34HyU8JNcYGnL6931EDrvNNjyCyqmrHyd_-AObihRI priority: 102 providerName: Scholars Portal |
Title | Antineoplastic treatment effect on bone mineral density in Mexican breast cancer patients |
URI | https://www.ncbi.nlm.nih.gov/pubmed/27821086 https://www.proquest.com/docview/1845312014 https://search.proquest.com/docview/1837284359 https://pubmed.ncbi.nlm.nih.gov/PMC5100258 |
Volume | 16 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbaIiEuiDeBshiEhISUbtax4_i4rVoVpFTVQqWFi-XYDqzEZqsmK5V_z4yTrBqOXHLxJHLG8_DYnz8T8kHlzthU8dhlSKqt3CzOTVbFTrhMKl9KF86tFRfZ-RX_shTLPSKGszABtG_L1VH9e31Ur34FbOX12k4HnNj0sjgRyBsq8uk-2ZdpOpTo_daBzJO8376c5dm0gQCcIz4ti5lKRIzE0wzSIt4wNMpF_0bkOylpDJe8k3_OHpGH_cSRzrsOPiZ7vn5C7hf91vhT8n2Odz4gHtwg9TLdIchpB9mgm5qWm9rT9SoQTVOH0PX2D13VtPC3GA1piQj1llq0hBvaU642z8jV2em3k_O4vzchtlAftPHMCpZUTBnuE1e5HGYhoAplpKmESl02q1xlk6qCBCY8K1nGnBcy8YJzo7zw6XNyUEOHXhKKfGCMGQFjqHhimVEW-ecTBV_wEEcj8mnQoL7u6DF0KCvyTHea1wghQ83r24i8RR3r7oTnzrX0nMsEqhbO4XPvgwQSU9SIfPlptk2jP39djIQ-9kLVBsbDmv4gAfQYuaxGkocjSfAcO24eBlv3nttoqHghLMG0iEfk3a4Z30Q0GgzjFmVSCWk9FSoiLzrb2P39YFsRkSOr2Qkgn_e4Bcw88Hr3Zv3qv998TR4wNPSw6n1IDtqbrX8Dc6a2nICnLOWE3Ds-vbhcTMLKAzwLnsNzcfxjEnzoLx3uG2I |
link.rule.ids | 230,315,733,786,790,870,891,12083,21416,24346,27955,27956,31752,31753,33777,33778,43343,43838,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagSMAF8SyBQg1CQkKKmjh2HJ_QClFtodsDtNJyshw_YA9kS5OVln_PTOINDQfOnliOZzzjsT9_Q8gbVTljC8VTVyKptnJ5WpkypE64UipfS9e_W1uclfML_mkplvHArY2wyp1P7B21W1s8Iz-CTATMBcIVf3_5K8WqUXi7Gkto3CS3eFFwtHO5HBOuXFZZFW8y86o8asEXVwhVK1OmMpFuJ7HoX498LSRN4ZLX4s_xfXIvbhzpbND0A3LDNw_J7UW8Gn9Evs2w5gPiwQ1SL9MRQU4HyAZdN7ReN57-XPVE09QhdL37TVcNXfgtekNaI0K9oxYt4YpGytX2Mbk4_nj-YZ7GugmphfygS3MrWBaYMtxnLrgKdiHw_8pIE4QqXJkHF2wWAgQw4VnNSua8kJkXnBvlhS-ekL0GBvSUUOQDY8wI0KHimWVGWeSfzxT04MGPJuTdbgb15UCPofu0oir1MN0aIWQ43XqbkEOcYz288ByXlp5xmUHWwjl097qXQGKKBpEv382mbfXJ1y8TobdRKKxBH9bEhwQwYuSymkgeTCRh5dhp807ZOq7cVv-1s4S8GpvxS0SjgRo3KFNICOuFUAnZH2xj_HsGWy6sXpUQObGaUQD5vKctzepHz-stkA5XVM_-P6xDcmd-vjjVpydnn5-TuwzNuT_mPiB73dXGv4BNUle_7FfCH56bD-8 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgSBMv3C-BwQxCQkJKk7p2Ej9Wg2oDOk3ApMGL5fjCqtG0WlJp8Os5Jzc1e9yzTywn5x5__kzIO5lZbSaShzZBUm1px2GmEx9aYZNUujy19bm1-XFyeMo_n4mzrau-atC-yRej4s9yVCzOa2zlemmiDicWncwPBPKGiixaWx_dJnfAZ1naNertBkKaxVm7iTnOkqiEMJwhSi0JmYxFiPTTDJIj3jM0yEjX4_JWYhqCJrey0Ow--dWtvwGfXIw2VT4y_65RO97oBR-Qe21tSqeNyENyyxWPyO683X1_TH5O8VoJhJxrZHemPUidNqgQuipoviocXS5qLmtqER1f_aWLgs7dFQZcmiMIvqIGje2Stqyu5RNyOvv04-AwbK9mCA20IFU4NoLFnknNXWy9zaDQge8sdaq9kBObjL31JvYecqRwLGcJs06ksROca-mEmzwlOwUs6DmhSDnGmBZgJpLHhmlpkOI-ljCDg1AdkA-detS6YeBQdeeSJapRq0KUGqpVXQVkHxWomkOkvfeqKU9jaIw4h-ne1hLIfVEguOa33pSlOvr-bSD0vhXyK1C20e1ZBVgx0mUNJPcGkuCcZjjcWZJqg0OpoKmGyAeVFw_Im34Yn0TAG6hxgzKTFCqHiZABedYYXv_2neEGJB2YZC-AlOHDETC0mjq8NawXN35yn-yefJypr0fHX16Suwwdqv7Hvkd2qsuNewUVWpW_rn3xP3b4Om4 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Antineoplastic+treatment+effect+on+bone+mineral+density+in+Mexican+breast+cancer+patients&rft.jtitle=BMC+cancer&rft.au=Monroy-Cisneros%2C+Karina&rft.au=Esparza-Romero%2C+Julian&rft.au=Valencia%2C+Mauro+E&rft.au=Guevara-Torres%2C+Alfonso+G&rft.date=2016-11-08&rft.pub=BioMed+Central+Ltd&rft.issn=1471-2407&rft.eissn=1471-2407&rft.volume=16&rft.issue=1&rft_id=info:doi/10.1186%2Fs12885-016-2905-x&rft.externalDBID=ISR&rft.externalDocID=A470585442 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2407&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2407&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2407&client=summon |