Repetitive Deformation Activates Focal Adhesion Kinase and ERK Mitogenic Signals in Human Caco-2 Intestinal Epithelial Cells through Src and Rac1

• Published in: The Journal of biological chemistry Vol. 282; no. 1; pp. 14 - 28
• Main Authors: Chaturvedi, Lakshmi S., Marsh, H. Michael, Shang, Xun, Zheng, Yi, Basson, Marc D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.01.2007; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Caco-2 Cells; Epithelial Cells - cytology; Extracellular Signal-Regulated MAP Kinases - metabolism; Focal Adhesion Protein-Tyrosine Kinases - metabolism; Focal Adhesion Protein-Tyrosine Kinases - physiology; Humans; Intestinal Mucosa - metabolism; Models, Biological; Mucous Membrane - pathology; Mutation; Phosphorylation; rac1 GTP-Binding Protein - physiology; Rats; Signal Transduction; src-Family Kinases - metabolism

Intestinal epithelial cells are subject to repetitive deformation during peristalsis and villous motility, whereas the mucosa atrophies during sepsis or ileus when such stimuli are abnormal. Such repetitive deformation stimulates intestinal epithelial proliferation via focal adhesion kinase (FAK) an...