The Diverse World of Foldamers: Endless Possibilities of Self-Assembly

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 14; p. 3276
• Main Author: Rinaldi, Samuele
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.07.2020; MDPI
• Subjects: Amino acids; Chemical bonds; foldamers; higher-order structures; Hydrogen bonds; Macromolecular Substances - chemistry; Models, Molecular; morphology; Nanostructures - chemistry; NMR; Nuclear magnetic resonance; Peptide Fragments - chemistry; Peptides; Polymers - chemistry; Protein Conformation, beta-Strand; Review; secondary structure; self-assembly; Spectrum analysis; structural investigation; Tissue engineering; secondary structure; self-assembly; fibers; helices; monolayers; morphology; structural investigation; higher-order structures; foldamers; vesicles

Different classes of foldamers, which are synthetic oligomers that adopt well-defined conformations in solution, have been the subject of extensive studies devoted to the elucidation of the forces driving their secondary structures and their potential as bioactive molecules. Regardless of the backbo...