Independent Signals Control Expression of the Calcineurin Inhibitory Proteins MCIP1 and MCIP2 in Striated Muscles

• Published in: Circulation research Vol. 87; no. 12; pp. e61 - e68
• Main Authors: Yang, John, Rothermel, Beverly, Vega, Rick B, Frey, Norbert, McKinsey, Timothy A, Olson, Eric N, Bassel-Duby, Rhonda, Williams, R Sanders
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 08.12.2000; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Animals; Calcineurin - physiology; Cells, Cultured; Exons; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Muscle Proteins - biosynthesis; Muscle Proteins - genetics; Muscle, Skeletal - physiology; Proteins; RNA, Messenger - biosynthesis; Signal Transduction; Thyroid Hormones - physiology; Transcription, Genetic; Transfection

ABSTRACT—Calcineurin, a calcium/calmodulin-regulated protein phosphatase, modulates gene expression in cardiac and skeletal muscles during development and in remodeling responses such as cardiac hypertrophy that are evoked by environmental stresses or disease. Recently, we identified two genes encod...