Plasma cell development and survival

• Published in: Immunological reviews Vol. 237; no. 1; pp. 140 - 159
• Main Authors: Oracki, Sarah A, Walker, Jennifer A, Hibbs, Margaret L, Corcoran, Lynn M, Tarlinton, David M
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.09.2010; Blackwell Publishing Ltd
• Subjects: Animals; Antibodies; autoantibodies; autoimmunity; B cells; B-cell receptor; B-Lymphocyte Subsets; B-Lymphocyte Subsets - cytology; B-Lymphocyte Subsets - immunology; Cell Differentiation; Cell Survival; cytology; Differentiation; Follicles; Germinal centers; Humans; immunology; Integration; Lymphocytes B; Plasma Cells; Plasma Cells - cytology; Plasma Cells - immunology; systemic lupus erythematosus

Plasma cells have long been recognized as the basis of humoral immunity, yet we are only now beginning to appreciate the complexities of plasma cell development and the fact that not all plasma cells are created equal. In vivo, plasma cells can arise from two developmental routes: one occurring outs...