Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells
Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position β69 (HLA-DPGlu69). This study was designed to clarify the preci...
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| Published in | Immunology Vol. 128; no. 1pt2; pp. e462 - e470 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
01.09.2009
Blackwell Publishing Ltd Blackwell Science Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0019-2805 1365-2567 1365-2567 |
| DOI | 10.1111/j.1365-2567.2008.03000.x |
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| Abstract | Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position β69 (HLA-DPGlu69). This study was designed to clarify the precise role of peptides in beryllium binding to the HLA-DP groove's pocket 4 and to identify peptides with higher affinity for pocket 4 that might prevent beryllium presentation and T-cell stimulation. Beryllium/HLA-DP interactions were analysed by the ability of beryllium to compete with CLIP and CLIP-derived peptides to HLA-DPGlu69 soluble molecule. The CLIP-derived low-affinity peptide CLIP-AA, could not outcompete beryllium; while the CLIP-derived high-affinity peptides CLIP-YY, CLIP-QY and CLIP-RF were only marginally influenced by the presence of beryllium in the competition assay. The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-γ (IFN-γ) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. CLIP-YY did inhibit beryllium presentation and T-cell activation, while CLIP-QY and CLIP-RF markedly enhanced the IFN-γ response to beryllium. Anti-HLA-DP monoclonal antibody blocked the beryllium-induced IFN-γ release in the presence of CLIP-QY (88%) and CLIP-RF (76%). A similar effect was observed for CLIP-YY capability to block IFN-γ release by beryllium stimulation in the presence of CLIP-QY (79%) and CLIP-RF (76%). Overall, these data support the proposal that HLA-DP high-affinity peptides might be used as a model for specific berylliosis therapy. |
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| AbstractList | Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position β69 (HLA-DPGlu69). This study was designed to clarify the precise role of peptides in beryllium binding to the HLA-DP groove's pocket 4 and to identify peptides with higher affinity for pocket 4 that might prevent beryllium presentation and T-cell stimulation. Beryllium/HLA-DP interactions were analysed by the ability of beryllium to compete with CLIP and CLIP-derived peptides to HLA-DPGlu69 soluble molecule. The CLIP-derived low-affinity peptide CLIP-AA, could not outcompete beryllium; while the CLIP-derived high-affinity peptides CLIP-YY, CLIP-QY and CLIP-RF were only marginally influenced by the presence of beryllium in the competition assay. The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-γ (IFN-γ) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. CLIP-YY did inhibit beryllium presentation and T-cell activation, while CLIP-QY and CLIP-RF markedly enhanced the IFN-γ response to beryllium. Anti-HLA-DP monoclonal antibody blocked the beryllium-induced IFN-γ release in the presence of CLIP-QY (88%) and CLIP-RF (76%). A similar effect was observed for CLIP-YY capability to block IFN-γ release by beryllium stimulation in the presence of CLIP-QY (79%) and CLIP-RF (76%). Overall, these data support the proposal that HLA-DP high-affinity peptides might be used as a model for specific berylliosis therapy. Summary Berylliosis is driven by the accumulation in the lung of beryllium‐specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position β69 (HLA‐DPGlu69). This study was designed to clarify the precise role of peptides in beryllium binding to the HLA‐DP groove’s pocket 4 and to identify peptides with higher affinity for pocket 4 that might prevent beryllium presentation and T‐cell stimulation. Beryllium/HLA‐DP interactions were analysed by the ability of beryllium to compete with CLIP and CLIP‐derived peptides to HLA‐DPGlu69 soluble molecule. The CLIP‐derived low‐affinity peptide CLIP‐AA, could not outcompete beryllium; while the CLIP‐derived high‐affinity peptides CLIP‐YY, CLIP‐QY and CLIP‐RF were only marginally influenced by the presence of beryllium in the competition assay. The effect of these CLIP‐derived high‐affinity peptides on beryllium presentation was determined by measuring interferon‐γ (IFN‐γ) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium‐hypersensitive subjects. CLIP‐YY did inhibit beryllium presentation and T‐cell activation, while CLIP‐QY and CLIP‐RF markedly enhanced the IFN‐γ response to beryllium. Anti‐HLA‐DP monoclonal antibody blocked the beryllium‐induced IFN‐γ release in the presence of CLIP‐QY (88%) and CLIP‐RF (76%). A similar effect was observed for CLIP‐YY capability to block IFN‐γ release by beryllium stimulation in the presence of CLIP‐QY (79%) and CLIP‐RF (76%). Overall, these data support the proposal that HLA‐DP high‐affinity peptides might be used as a model for specific berylliosis therapy. Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position beta69 (HLA-DPGlu69). This study was designed to clarify the precise role of peptides in beryllium binding to the HLA-DP groove's pocket 4 and to identify peptides with higher affinity for pocket 4 that might prevent beryllium presentation and T-cell stimulation. Beryllium/HLA-DP interactions were analysed by the ability of beryllium to compete with CLIP and CLIP-derived peptides to HLA-DPGlu69 soluble molecule. The CLIP-derived low-affinity peptide CLIP-AA, could not outcompete beryllium; while the CLIP-derived high-affinity peptides CLIP-YY, CLIP-QY and CLIP-RF were only marginally influenced by the presence of beryllium in the competition assay. The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. CLIP-YY did inhibit beryllium presentation and T-cell activation, while CLIP-QY and CLIP-RF markedly enhanced the IFN-gamma response to beryllium. Anti-HLA-DP monoclonal antibody blocked the beryllium-induced IFN-gamma release in the presence of CLIP-QY (88%) and CLIP-RF (76%). A similar effect was observed for CLIP-YY capability to block IFN-gamma release by beryllium stimulation in the presence of CLIP-QY (79%) and CLIP-RF (76%). Overall, these data support the proposal that HLA-DP high-affinity peptides might be used as a model for specific berylliosis therapy. Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position beta69 (HLA-DPGlu69). This study was designed to clarify the precise role of peptides in beryllium binding to the HLA-DP groove's pocket 4 and to identify peptides with higher affinity for pocket 4 that might prevent beryllium presentation and T-cell stimulation. Beryllium/HLA-DP interactions were analysed by the ability of beryllium to compete with CLIP and CLIP-derived peptides to HLA-DPGlu69 soluble molecule. The CLIP-derived low-affinity peptide CLIP-AA, could not outcompete beryllium; while the CLIP-derived high-affinity peptides CLIP-YY, CLIP-QY and CLIP-RF were only marginally influenced by the presence of beryllium in the competition assay. The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. CLIP-YY did inhibit beryllium presentation and T-cell activation, while CLIP-QY and CLIP-RF markedly enhanced the IFN-gamma response to beryllium. Anti-HLA-DP monoclonal antibody blocked the beryllium-induced IFN-gamma release in the presence of CLIP-QY (88%) and CLIP-RF (76%). A similar effect was observed for CLIP-YY capability to block IFN-gamma release by beryllium stimulation in the presence of CLIP-QY (79%) and CLIP-RF (76%). Overall, these data support the proposal that HLA-DP high-affinity peptides might be used as a model for specific berylliosis therapy.Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position beta69 (HLA-DPGlu69). This study was designed to clarify the precise role of peptides in beryllium binding to the HLA-DP groove's pocket 4 and to identify peptides with higher affinity for pocket 4 that might prevent beryllium presentation and T-cell stimulation. Beryllium/HLA-DP interactions were analysed by the ability of beryllium to compete with CLIP and CLIP-derived peptides to HLA-DPGlu69 soluble molecule. The CLIP-derived low-affinity peptide CLIP-AA, could not outcompete beryllium; while the CLIP-derived high-affinity peptides CLIP-YY, CLIP-QY and CLIP-RF were only marginally influenced by the presence of beryllium in the competition assay. The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon-gamma (IFN-gamma) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. CLIP-YY did inhibit beryllium presentation and T-cell activation, while CLIP-QY and CLIP-RF markedly enhanced the IFN-gamma response to beryllium. Anti-HLA-DP monoclonal antibody blocked the beryllium-induced IFN-gamma release in the presence of CLIP-QY (88%) and CLIP-RF (76%). A similar effect was observed for CLIP-YY capability to block IFN-gamma release by beryllium stimulation in the presence of CLIP-QY (79%) and CLIP-RF (76%). Overall, these data support the proposal that HLA-DP high-affinity peptides might be used as a model for specific berylliosis therapy. SummaryPlease cite this article in press as: Amicosante M. et al. Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells, Immunology (2009)Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented principally by human leucocyte antigen DP molecules carrying a glutamate at position beta 69 (HLA-DPGlu69). This study was designed to clarify the precise role of peptides in beryllium binding to the HLA-DP groove's pocket 4 and to identify peptides with higher affinity for pocket 4 that might prevent beryllium presentation and T-cell stimulation. Beryllium-HLA-DP interactions were analysed by the ability of beryllium to compete with CLIP and CLIP-derived peptides to HLA-DPGlu69 soluble molecule. The CLIP-derived low-affinity peptide CLIP-AA, could not outcompete beryllium; while the CLIP-derived high-affinity peptides CLIP-YY, CLIP-QY and CLIP-RF were only marginally influenced by the presence of beryllium in the competition assay. The effect of these CLIP-derived high-affinity peptides on beryllium presentation was determined by measuring interferon- gamma (IFN- gamma ) release upon beryllium stimulation of peripheral blood mononuclear cells obtained from beryllium-hypersensitive subjects. CLIP-YY did inhibit beryllium presentation and T-cell activation, while CLIP-QY and CLIP-RF markedly enhanced the IFN- gamma response to beryllium. Anti-HLA-DP monoclonal antibody blocked the beryllium-induced IFN- gamma release in the presence of CLIP-QY (88%) and CLIP-RF (76%). A similar effect was observed for CLIP-YY capability to block IFN- gamma release by beryllium stimulation in the presence of CLIP-QY (79%) and CLIP-RF (76%). Overall, these data support the proposal that HLA-DP high-affinity peptides might be used as a model for specific berylliosis therapy. |
| Author | Dweik, Raed Saltini, Cesare Berretta, Floriana Amicosante, Massimo |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19191908$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/intimm/dxg057 10.1126/science.8105536 10.1183/09031936.01.00106201 10.1084/jem.171.4.1123 10.4049/jimmunol.175.10.7029 10.1056/NEJM198904273201702 10.1002/ajim.20045 10.4049/jimmunol.163.3.1647 10.1007/s00251-004-0735-5 10.1006/clin.1994.1061 10.4049/jimmunol.174.7.4316 10.1084/jem.20030121 10.1016/j.clim.2006.03.012 10.4049/jimmunol.169.12.6928 10.1186/1465-9921-6-94 10.1016/S1474-4422(05)70167-8 10.4049/jimmunol.171.12.6910 10.1016/j.jinorgbio.2005.02.017 10.1073/pnas.220430797 10.1165/rcmb.2004-0090OC 10.1046/j.1399-0039.2003.00131.x 10.4049/jimmunol.166.5.3549 10.1164/ajrccm.165.6.2104002 10.1016/S0198-8859(01)00261-0 10.1172/JCI0215846 10.1084/jem.20021762 10.1002/(SICI)1097-0274(199710)32:4<337::AID-AJIM3>3.0.CO;2-R 10.1016/S0300-483X(01)00410-3 10.1586/14760584.4.6.881 |
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| References | 2001; 166 2001; 165 2005; 174 2005; 175 2002; 110 2004; 46 1993; 262 2003; 171 2003; 15 1999; 163 2005; 22 2001; 62 2003; 197 2004; 31 1997; 32 2002; 165 2002; 169 1989; 320 2000; 97 1990; 171 2005; 4 2006; 121 2005; 6 2001; 18 2003; 62 1994; 71 2005; 99 2005; 56 Wang Z (e_1_2_6_8_2) 1999; 163 e_1_2_6_31_2 e_1_2_6_30_2 e_1_2_6_18_2 e_1_2_6_19_2 e_1_2_6_12_2 e_1_2_6_13_2 e_1_2_6_10_2 e_1_2_6_11_2 e_1_2_6_16_2 e_1_2_6_14_2 e_1_2_6_15_2 e_1_2_6_20_2 e_1_2_6_7_2 e_1_2_6_9_2 e_1_2_6_29_2 e_1_2_6_4_2 e_1_2_6_3_2 e_1_2_6_6_2 e_1_2_6_5_2 Amicosante M (e_1_2_6_17_2) 2005; 22 e_1_2_6_24_2 e_1_2_6_23_2 e_1_2_6_2_2 e_1_2_6_22_2 e_1_2_6_21_2 e_1_2_6_28_2 e_1_2_6_27_2 e_1_2_6_26_2 e_1_2_6_25_2 11551429 - Toxicology. 2001 Aug 13;165(1):27-38 16372883 - Expert Rev Vaccines. 2005 Dec;4(6):881-9 8105536 - Science. 1993 Oct 8;262(5131):242-4 9258386 - Am J Ind Med. 1997 Oct;32(4):337-40 11716174 - Eur Respir J. 2001 Oct;18(4):677-84 10415070 - J Immunol. 1999 Aug 1;163(3):1647-53 16109363 - Lancet Neurol. 2005 Sep;4(9):567-75 12471126 - J Immunol. 2002 Dec 15;169(12):6928-34 12697658 - Int Immunol. 2003 May;15(5):565-76 15273960 - Am J Ind Med. 2004 Aug;46(2):95-103 16098233 - Respir Res. 2005;6:94 15565337 - Immunogenetics. 2005 Jan;56(10):754-9 14662898 - J Immunol. 2003 Dec 15;171(12):6910-8 8181181 - Clin Immunol Immunopathol. 1994 May;71(2):123-9 16315779 - Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):175-9 16272364 - J Immunol. 2005 Nov 15;175(10):7029-37 15833341 - J Inorg Biochem. 2005 May;99(5):1174-81 11897645 - Am J Respir Crit Care Med. 2002 Mar 15;165(6):788-94 14617029 - Tissue Antigens. 2003 Dec;62(6):459-71 12438445 - J Clin Invest. 2002 Nov;110(10):1473-82 15256386 - Am J Respir Cell Mol Biol. 2004 Oct;31(4):470-7 12756270 - J Exp Med. 2003 May 19;197(10):1345-53 11207315 - J Immunol. 2001 Mar 1;166(5):3549-55 12615898 - J Exp Med. 2003 Mar 3;197(5):567-74 2469014 - N Engl J Med. 1989 Apr 27;320(17):1103-9 11050177 - Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12717-22 2139099 - J Exp Med. 1990 Apr 1;171(4):1123-40 11423174 - Hum Immunol. 2001 Jul;62(7):686-93 15778396 - J Immunol. 2005 Apr 1;174(7):4316-24 16697706 - Clin Immunol. 2006 Nov;121(2):134-43 |
| References_xml | – volume: 171 start-page: 1123 year: 1990 end-page: 30 article-title: Biased accumulation of T lymphocytes with “memory”‐type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung publication-title: J Exp Med – volume: 32 start-page: 337 year: 1997 end-page: 40 article-title: Interaction of genetic and exposure factors in the prevalence of berylliosis publication-title: Am J Ind Med – volume: 4 start-page: 567 year: 2005 end-page: 75 article-title: Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action publication-title: Lancet Neurol – volume: 18 start-page: 677 year: 2001 end-page: 84 article-title: Major histocompatibility locus genetic markers of beryllium sensitization and disease publication-title: Eur Respir J – volume: 165 start-page: 788 year: 2002 end-page: 94 article-title: Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity publication-title: Am J Respir Crit Care Med – volume: 97 start-page: 12717 year: 2000 end-page: 22 article-title: Beryllium presentation to CD4 T cells underlies disease‐susceptibility HLA‐DP alleles in chronic beryllium disease publication-title: Proc Natl Acad Sci USA – volume: 99 start-page: 1174 year: 2005 end-page: 81 article-title: Beryllium binding at neutral pH: the importance of the Be‐O‐Be motif publication-title: J Inorg Biochem – volume: 6 start-page: 94 year: 2005 article-title: Identification of HLA‐DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis‐associated supratypic marker HLA‐DPGlubeta69 publication-title: Respir Res – volume: 171 start-page: 6910 year: 2003 end-page: 8 article-title: Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease publication-title: J Immunol – volume: 62 start-page: 686 year: 2001 end-page: 93 article-title: Beryllium binding to HLA‐DP molecule carrying the marker of susceptibility to berylliosis glutamate beta 69 publication-title: Hum Immunol – volume: 169 start-page: 6928 year: 2002 end-page: 34 article-title: HLA‐DP4, the most frequent HLA II molecule, defines a new supertype of peptide‐binding specificity publication-title: J Immunol – volume: 163 start-page: 1647 year: 1999 end-page: 53 article-title: Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA‐DPB1 and ‐DPA1 alleles publication-title: J Immunol – volume: 15 start-page: 565 year: 2003 end-page: 76 article-title: Functional analysis of HLA‐DP polymorphism: a crucial role for DPbeta residues 9, 11, 35, 55, 56, 69 and 84–87 in T cell allorecognition and peptide binding publication-title: Int Immunol – volume: 4 start-page: 881 year: 2005 end-page: 9 article-title: Peptide‐based immunotherapy: a novel strategy for allergic disease publication-title: Expert Rev Vaccines – volume: 175 start-page: 7029 year: 2005 end-page: 37 article-title: Beryllium presentation to CD4 T cells is dependent on a single amino acid residue of the MHC class II beta‐chain publication-title: J Immunol – volume: 174 start-page: 4316 year: 2005 end-page: 24 article-title: Activation pathways implicate anti‐HLA‐DP and anti‐LFA‐1 antibodies as lead candidates for intervention in chronic berylliosis publication-title: J Immunol – volume: 197 start-page: 567 year: 2003 end-page: 74 article-title: Components of the ligand for a Ni reactive human T cell clone publication-title: J Exp Med – volume: 31 start-page: 470 year: 2004 end-page: 7 article-title: Beryllium‐ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium disease publication-title: Am J Respir Cell Mol Biol – volume: 165 start-page: 27 year: 2001 end-page: 38 article-title: Beryllium sensitivity is linked to HLA‐DP genotype publication-title: Toxicology – volume: 56 start-page: 754 year: 2005 end-page: 9 article-title: Characterization of natural peptide ligands from HLA‐DP2: new insights into HLA‐DP peptide‐binding motifs publication-title: Immunogenetics – volume: 320 start-page: 1103 year: 1989 end-page: 9 article-title: Maintenance of alveolitis in patients with chronic beryllium disease by beryllium‐specific helper T cells publication-title: N Engl J Med – volume: 110 start-page: 1473 year: 2002 end-page: 82 article-title: Target organ localization of memory CD4(+) T cells in patients with chronic beryllium disease publication-title: J Clin Invest – volume: 46 start-page: 95 year: 2004 end-page: 103 article-title: The association between HLA‐DPB1Glu69 and chronic beryllium disease and beryllium sensitization publication-title: Am J Ind Med – volume: 262 start-page: 242 year: 1993 end-page: 4 article-title: HLA‐DPB1 glutamate 69: a genetic marker of beryllium disease publication-title: Science – volume: 197 start-page: 1345 year: 2003 end-page: 53 article-title: A new type of metal recognition by human T cells: contact residues for peptide‐independent bridging of T cell receptor and major histocompatibility complex by nickel publication-title: J Exp Med – volume: 62 start-page: 459 year: 2003 end-page: 71 article-title: Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen‐DP polymorphism on peptide‐binding specificity publication-title: Tissue Antigens – volume: 71 start-page: 123 year: 1994 end-page: 9 article-title: Chronic beryllium disease. From the workplace to cellular immunology, molecular immunogenetics, and back publication-title: Clin Immunol Immunopath – volume: 22 start-page: 175 year: 2005 end-page: 9 article-title: Role of the berylliosis‐associated HLA‐DPGlu69 supratypic variant in determining the response to beryllium in a blood T‐cells beryllium‐stimulated proliferation test publication-title: Sarcoidosis Vasc Diffuse Lung Dis – volume: 166 start-page: 3549 year: 2001 end-page: 55 article-title: HLA‐DP allele‐specific T cell responses to beryllium account for DP‐associated susceptibility to chronic beryllium disease publication-title: J Immunol – volume: 121 start-page: 134 year: 2006 end-page: 43 article-title: T‐cell recognition in chronic beryllium disease publication-title: Clin Immunol – ident: e_1_2_6_23_2 doi: 10.1093/intimm/dxg057 – ident: e_1_2_6_6_2 doi: 10.1126/science.8105536 – ident: e_1_2_6_9_2 doi: 10.1183/09031936.01.00106201 – ident: e_1_2_6_2_2 doi: 10.1084/jem.171.4.1123 – ident: e_1_2_6_18_2 doi: 10.4049/jimmunol.175.10.7029 – ident: e_1_2_6_3_2 doi: 10.1056/NEJM198904273201702 – ident: e_1_2_6_13_2 doi: 10.1002/ajim.20045 – volume: 163 start-page: 1647 year: 1999 ident: e_1_2_6_8_2 article-title: Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA‐DPB1 and ‐DPA1 alleles publication-title: J Immunol doi: 10.4049/jimmunol.163.3.1647 – ident: e_1_2_6_24_2 doi: 10.1007/s00251-004-0735-5 – ident: e_1_2_6_5_2 doi: 10.1006/clin.1994.1061 – ident: e_1_2_6_29_2 doi: 10.4049/jimmunol.174.7.4316 – ident: e_1_2_6_26_2 doi: 10.1084/jem.20030121 – ident: e_1_2_6_27_2 doi: 10.1016/j.clim.2006.03.012 – ident: e_1_2_6_20_2 doi: 10.4049/jimmunol.169.12.6928 – ident: e_1_2_6_14_2 doi: 10.1186/1465-9921-6-94 – ident: e_1_2_6_30_2 doi: 10.1016/S1474-4422(05)70167-8 – ident: e_1_2_6_12_2 doi: 10.4049/jimmunol.171.12.6910 – ident: e_1_2_6_22_2 doi: 10.1016/j.jinorgbio.2005.02.017 – ident: e_1_2_6_16_2 doi: 10.1073/pnas.220430797 – ident: e_1_2_6_28_2 doi: 10.1165/rcmb.2004-0090OC – ident: e_1_2_6_21_2 doi: 10.1046/j.1399-0039.2003.00131.x – ident: e_1_2_6_15_2 doi: 10.4049/jimmunol.166.5.3549 – ident: e_1_2_6_11_2 doi: 10.1164/ajrccm.165.6.2104002 – ident: e_1_2_6_19_2 doi: 10.1016/S0198-8859(01)00261-0 – ident: e_1_2_6_4_2 doi: 10.1172/JCI0215846 – ident: e_1_2_6_25_2 doi: 10.1084/jem.20021762 – ident: e_1_2_6_7_2 doi: 10.1002/(SICI)1097-0274(199710)32:4<337::AID-AJIM3>3.0.CO;2-R – ident: e_1_2_6_10_2 doi: 10.1016/S0300-483X(01)00410-3 – volume: 22 start-page: 175 year: 2005 ident: e_1_2_6_17_2 article-title: Role of the berylliosis‐associated HLA‐DPGlu69 supratypic variant in determining the response to beryllium in a blood T‐cells beryllium‐stimulated proliferation test publication-title: Sarcoidosis Vasc Diffuse Lung Dis – ident: e_1_2_6_31_2 doi: 10.1586/14760584.4.6.881 – reference: 11423174 - Hum Immunol. 2001 Jul;62(7):686-93 – reference: 15565337 - Immunogenetics. 2005 Jan;56(10):754-9 – reference: 2139099 - J Exp Med. 1990 Apr 1;171(4):1123-40 – reference: 10415070 - J Immunol. 1999 Aug 1;163(3):1647-53 – reference: 11050177 - Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12717-22 – reference: 11716174 - Eur Respir J. 2001 Oct;18(4):677-84 – reference: 8181181 - Clin Immunol Immunopathol. 1994 May;71(2):123-9 – reference: 15833341 - J Inorg Biochem. 2005 May;99(5):1174-81 – reference: 16697706 - Clin Immunol. 2006 Nov;121(2):134-43 – reference: 14617029 - Tissue Antigens. 2003 Dec;62(6):459-71 – reference: 11207315 - J Immunol. 2001 Mar 1;166(5):3549-55 – reference: 2469014 - N Engl J Med. 1989 Apr 27;320(17):1103-9 – reference: 14662898 - J Immunol. 2003 Dec 15;171(12):6910-8 – reference: 12615898 - J Exp Med. 2003 Mar 3;197(5):567-74 – reference: 16109363 - Lancet Neurol. 2005 Sep;4(9):567-75 – reference: 16272364 - J Immunol. 2005 Nov 15;175(10):7029-37 – reference: 12697658 - Int Immunol. 2003 May;15(5):565-76 – reference: 16315779 - Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):175-9 – reference: 8105536 - Science. 1993 Oct 8;262(5131):242-4 – reference: 15778396 - J Immunol. 2005 Apr 1;174(7):4316-24 – reference: 12438445 - J Clin Invest. 2002 Nov;110(10):1473-82 – reference: 15273960 - Am J Ind Med. 2004 Aug;46(2):95-103 – reference: 16098233 - Respir Res. 2005;6:94 – reference: 16372883 - Expert Rev Vaccines. 2005 Dec;4(6):881-9 – reference: 9258386 - Am J Ind Med. 1997 Oct;32(4):337-40 – reference: 12756270 - J Exp Med. 2003 May 19;197(10):1345-53 – reference: 15256386 - Am J Respir Cell Mol Biol. 2004 Oct;31(4):470-7 – reference: 12471126 - J Immunol. 2002 Dec 15;169(12):6928-34 – reference: 11551429 - Toxicology. 2001 Aug 13;165(1):27-38 – reference: 11897645 - Am J Respir Crit Care Med. 2002 Mar 15;165(6):788-94 |
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| Snippet | Berylliosis is driven by the accumulation in the lung of beryllium-specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented... Summary Berylliosis is driven by the accumulation in the lung of beryllium‐specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented... Berylliosis is driven by the accumulation in the lung of beryllium‐specific T helper type 1 (Th1) cells recognizing beryllium as antigen when presented... SummaryPlease cite this article in press as: Amicosante M. et al. Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the... |
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| SubjectTerms | Adult antigen presentation Antigens, Differentiation, B-Lymphocyte Antigens, Differentiation, B-Lymphocyte - immunology Antigens, Differentiation, B-Lymphocyte - metabolism Berylliosis Berylliosis - immunology Berylliosis - metabolism beryllium Beryllium - immunology Beryllium - metabolism biosynthesis chemistry CLIP Female Histocompatibility Antigens Class II Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism HLA-DP Antigens HLA-DP Antigens - chemistry HLA-DP Antigens - immunology HLA-DP Antigens - metabolism human leucocyte antigen human leucocyte antigen-DP Humans immunogenetic immunogenetics immunology Interferon-gamma Interferon-gamma - biosynthesis Interferon-gamma - immunology Lymphocyte Activation Lymphocyte Activation - immunology Male metabolism Middle Aged Original peptide-based therapy T cells T-lymphocytes T-Lymphocytes - immunology T-Lymphocytes - metabolism |
| Title | Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells |
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