Immune regulatory effects of high dose vitamin D3 supplementation in a randomized controlled trial in relapsing remitting multiple sclerosis patients receiving IFNβ; the SOLARIUM study

• Published in: Journal of neuroimmunology Vol. 300; pp. 47 - 56
• Main Authors: Muris, Anne-Hilde, Smolders, Joost, Rolf, Linda, Thewissen, Marielle, Hupperts, Raymond, Damoiseaux, Jan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.11.2016
• Subjects: Allergy and Immunology; Immune regulation; Lymphocytes; Neurology; Pathogenic/encephalitogenic Th cells; Relapsing remitting multiple sclerosis; Vitamin D supplementation; RR; RCT; iTreg; IFNβ-1a; CNS; Breg; TNF; Lymphocytes; SOLAR; Vitamin D supplementation; nTreg; SOLARIUM; WBC; Th cell; Relapsing remitting multiple sclerosis; BMI; EDSS; IL; PMA; MS; Treg; Immune regulation; PBMC; Pathogenic/encephalitogenic Th cells; LAP; HC; BFA; GMCSF; phorbol 12-myristate 13-acetate; expanded disability status scale; natural Treg; white blood cell count; granulocyte macrophage colony-stimulating factor; body mass index; regulatory B cell; central nervous system; relapsing remitting; supplementation of VigantoL®Oil versus placebo as add-on in patients with relapsing remitting multiple sclerosis receiving Rebif® treatment; healthy control; SOLAR Immune Modulating effects; latency activated protein of TGFβ; interferon beta-1a; T Helper; brefeldin A; interleukin; peripheral blood mononuclear cells; multiple sclerosis; regulatory T cell; randomized controlled trial; tumor necrosis factor; inducible Treg

Multiple sclerosis (MS) is characterized by a disturbed immune homeostasis and low serum vitamin D levels are associated with an increased disease activity. While vitamin D has been hypothesized to promote the maintenance of immune homeostasis, vitamin D supplementation could be of benefit to patien...