Inhibitory effects of fruit juices on cytochrome P450 2C9 activity in vitro

• Published in: Bioscience, biotechnology, and biochemistry Vol. 72; no. 2; pp. 406 - 411
• Main Authors: Hidaka, M.(Kyushu Univ. of Health and Welfare, Nobeoka, Miyazaki (Japan)), Nagata, M, Kawano, Y, Sekiya, H, Kai, H, Yamasaki, K, Okumura, M, Arimori, K
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.02.2008; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: ANANAS (FRUITS); Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases - metabolism; Beverages; Biological and medical sciences; bromelain; Bromelains - pharmacology; CITOCROMO P450; COUMAFENE; Cytochrome P-450 CYP2C9; CYTOCHROME P450; cytochrome P450 2C9 (CYP2C9); DRUGS; Fruit; FRUIT JUICES; Fundamental and applied biological sciences. Psychology; JUGO DE FRUTAS; JUS DE FRUITS; MEDICAMENT; MEDICAMENTOS; METABOLISM; METABOLISME; METABOLISMO; Microsomes, Liver - enzymology; PINA; pineapple; PINEAPPLES; PROTEASAS; PROTEASE; Protease Inhibitors - pharmacology; PROTEASES; Ultrafiltration; WARFARIN; WARFARINA; pineapple; Cytochrome P450; Bromelains; cytochrome P450 2C9 (CYP2C9); Inhibition; Fruit juice; Biological activity; bromelain

There is limited information on the effect of fruits on human cytochrome P450 (CYP) 2C9 activity. The objective of this study was to determine the effect of fruit juice on CYP2C9-mediated drug metabolism. Nine citrus fruits and eight tropical fruits were chosen. We investigated effects of the fruits...