Morphologic Characterization of Preoperatively Treated Prostate Cancer: Toward a Post-Therapy Histologic Classification

• Published in: European urology Vol. 57; no. 6; pp. 1030 - 1038
• Main Authors: Efstathiou, Eleni, Abrahams, Neil A, Tibbs, Rita F, Wang, Xuemei, Pettaway, Curtis A, Pisters, Louis L, Mathew, Paul F, Do, Kim-Anh, Logothetis, Christopher J, Troncoso, Patricia
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 01.06.2010
• Subjects: Adult; Aged; Androgen Antagonists - pharmacology; Androgen Antagonists - therapeutic use; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Cluster Analysis; Gynecology. Andrology. Obstetrics; Humans; Male; Male genital diseases; Medical sciences; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nephrology. Urinary tract diseases; Prognosis; Proportional Hazards Models; Prostate - drug effects; Prostate - pathology; Prostate-Specific Antigen - blood; Prostatectomy; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Retrospective Studies; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urology; Heterogeneity; Neoadjuvant therapy; Cribriform; Intraductal carcinoma; Preoperative therapy; Classification; Prostate cancer; Intraductal spread; Ductal carcinoma; Nephrology; Urinary system disease; Prostate disease; Histology; Malignant tumor; Neoadjuvant treatment; Urology; Characterization; Preoperative; Male genital diseases; Cancer

Abstract Background Preoperative treatment of prostate cancer (PCa) changes morphology of residual tumors so that the Gleason score is no longer valid. Objective To codify morphologic features of preoperatively treated PCa and identify potential classifiers predictive of outcome. Design, setting, an...